Popular Trials
Local Anesthetic
Exparel for Craniofacial Pain
This trial tests if injecting Exparel into the nasal area can help people with craniofacial pain. Exparel is a long-lasting pain reliever, and the study focuses on those who usually get pain relief from Lidocaine during ENT procedures.
Anti-epileptic drug
Gabapentin for Neuropathic Pain in Children
This trial aims to determine how effective gabapentin is in reducing and resolving pain in children with severe brain-based developmental disabilities. These children often experience unexplained periods of pain and irritability, and the
Procedure
Lidocaine Patch for Peripheral Neuropathy
This trial will compare a lidocaine patch to a placebo patch to see if the lidocaine patch helps reduce neuropathic pain. Measurements and a visual scale will track pain severity. The study will also assess a hybrid biomarker to distinguish between active and placebo treatments.
Focused Ultrasound
Focused Ultrasound for Trigeminal Neuralgia
This trial is testing a new, non-invasive way to treat Trigeminal Neuralgia that uses ultrasound waves to target and heat up the pain-conducting nerves. The goal is to see if this treatment is safe and effective.
Procedure
Focused Ultrasound for Neuropathic Pain
This trial is testing a new treatment that uses sound waves directed at specific parts of the brain to help reduce pain. It targets patients with ongoing neuropathic pain that hasn't been managed well by other treatments. The sound waves aim to improve the function of brain areas that process pain signals. This noninvasive treatment option has shown promise in treating chronic neuropathic pain.
Popular Filters
Trials for Diabetic Neuropathy Patients
Procedure
Tetrodotoxin for Chemotherapy-Induced Neuropathic Pain
This trial is testing the effects of the study drug on neuropathic pain caused by chemotherapy. It will last 13 weeks and participants will be randomly assigned to either the study drug or placebo group.
Cannabinoid
Cannabis Derivatives for Diabetic Neuropathy
This trial tests if cannabis derivatives (THC, CBD, and their combination) can reduce chronic diabetic nerve pain in Veterans. Veterans often don't get enough relief from standard treatments, so this study aims to find out if cannabis can help. The trial will test if these cannabis compounds are effective. Cannabis has been studied for its potential to alleviate pain in various conditions, including diabetic neuropathy, but its long-term safety and efficacy remain uncertain.
Neurostimulation Device
Micro-Implantable Pulse Generator for Chronic Pain
This trial is testing whether adding peripheral nerve stimulation to conventional medical management is more effective and safe than just using conventional medical management for chronic, intractable peripheral neuralgia that is of post-traumatic or post-surgical origin.
Behavioural Intervention
Yoga for Peripheral Neuropathy
This trial is testing if yoga can help reduce nerve pain caused by cancer treatment. It will compare yoga classes, educational sessions about nerve pain and yoga, and typical care. The study aims to see if yoga can improve balance, reduce falls, and enhance quality of life for patients with chemotherapy-induced nerve pain. Yoga has been shown to improve cancer-related fatigue and sleep quality in breast cancer patients during and following treatment.
Behavioural Intervention
Electroacupuncture for Neuropathic Pain
This trial is testing if electroacupuncture, which uses needles and a small electrical current, can help reduce pain in cancer survivors who have pain from chemotherapy. Electroacupuncture has been studied for its potential to relieve cancer pain and improve quality of life in cancer patients.
Trials for Chronic Pain Patients
Deep Brain Stimulation
DBS for Chronic Pain
This trial is testing a new way to provide deep brain stimulation (DBS) for people with chronic pain that has not been relieved by other treatments. DBS involves surgically placing a small device in the brain that sends electrical signals to specific areas. The goal of this trial is to find out whether DBS is more effective when it is turned on only when needed, rather than continuously.
Neurostimulation Device
Micro-Implantable Pulse Generator for Chronic Pain
This trial is testing whether adding peripheral nerve stimulation to conventional medical management is more effective and safe than just using conventional medical management for chronic, intractable peripheral neuralgia that is of post-traumatic or post-surgical origin.
Behavioural Intervention
Yoga for Peripheral Neuropathy
This trial is testing if yoga can help reduce nerve pain caused by cancer treatment. It will compare yoga classes, educational sessions about nerve pain and yoga, and typical care. The study aims to see if yoga can improve balance, reduce falls, and enhance quality of life for patients with chemotherapy-induced nerve pain. Yoga has been shown to improve cancer-related fatigue and sleep quality in breast cancer patients during and following treatment.
Non-invasive Brain Stimulation
Noninvasive Brain Stimulation for Diabetic Neuropathy
This trial is testing a new treatment called non-invasive brain stimulation (ESSTim) for people with pain from diabetic neuropathy. The treatment uses mild electrical signals to change how the brain processes pain. Researchers believe this could be more effective. Non-invasive brain stimulation techniques have been explored for their potential to reduce chronic pain by altering brain activity.
Phase 3 Trials
Topical Analgesic
High-Dose vs Low-Dose Capsaicin for Neuropathic Pain
This trial is testing a new topical pain medication against a low-dose capsaicin control to see if it is more effective and safe in treating moderate to severe post-surgical neuropathic pain.
Glutamate Receptor Antagonist
Basimglurant for Trigeminal Neuralgia
This trial is testing a medication called basimglurant to see if it can help reduce severe facial pain in adults with Trigeminal Neuralgia. The medication works by blocking a specific receptor in the nervous system to lower pain signals. Researchers will measure changes in pain using patient diaries and feedback.
Antiepileptic
Brivaracetam for Neuropathic Pain in SCI
This trial is testing brivaracetam, a medication that may help reduce severe pain in people with spinal cord injuries. It targets a specific protein in the spinal cord that is linked to pain. The study aims to see if this treatment is effective for those who do not respond well to other pain medications.
Trials With No Placebo
Behavioural Intervention
Virtual Reality Self-Hypnosis for Pain Relief
This trial is looking at whether a self-hypnosis software, used with a virtual reality device, can help to relieve pain in HIV patients. The study will assess the safety, usability, and effectiveness
Topical Analgesic
High-Dose vs Low-Dose Capsaicin for Neuropathic Pain
This trial is testing a new topical pain medication against a low-dose capsaicin control to see if it is more effective and safe in treating moderate to severe post-surgical neuropathic pain.
NMDA Receptor Antagonist
Ketamine Infusion for Neuralgia
This trial is testing if giving ketamine can help reduce severe nerve pain in patients with brachial plexus injuries. Ketamine works by blocking pain signals to the brain. The study aims to see if this reduces the need for other pain medications. Ketamine has been reported to enhance the pain-relieving effects of local anesthetics and is used primarily for patients who are tolerant to opioids and those with severe acute pain.
Behavioural Intervention
Scrambler Therapy for Neuropathic Pain
This trial tests if Scrambler Therapy can reduce pain in patients with corticobasal syndrome. The therapy uses electrical signals to trick the brain into feeling non-painful sensations instead of pain. The goal is to see if this treatment can lower pain levels significantly over a short period. Scrambler Therapy is a noninvasive technique that substitutes pain information with non-painful sensations.
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Frequently Asked Questions
Introduction to nerve pain
What are the top hospitals conducting nerve pain research?
Nerve pain, also known as neuropathic pain, can be debilitating and challenging to manage. However, leading hospitals across the United States are actively engaged in cutting-edge clinical trials to find innovative solutions for this condition. Stanford University, with its main campus located in Stanford and an additional center in Palo Alto, is paving the way with three ongoing nerve pain trials and a cumulative total of six past studies. Notably, their first recorded nerve pain trial dates back to 2016, demonstrating their commitment to tackling this complex issue.
In sunny Miami, the University of Miami has emerged as a significant player in nerve pain research. With three active clinical trials currently underway and four completed studies under their belt since initiating their first trial in 2017, they are dedicated to advancing understanding and treatment options for individuals experiencing nerve-related discomfort.
Meanwhile, all the way up north in Minneapolis at the University of Minnesota's renowned medical institution lies another hub of innovation when it comes to combating nerve pain. Having conducted five comprehensive trials thus far since embarking on their inaugural study in 2016 while simultaneously engaging with three active ones; they continue making strides towards improving patients' quality of life by addressing this often-agonizing ailment.
Boston's Massachusetts General Hospital rounds out our list but certainly not lacking when it comes to contributions against neuropathic agony. Since conducting its first groundbreaking trial back in2006,todaythey have three ongoing research investigations focused exclusively on tackling nerve pain while having garnered commendable completion recordsof six such tests throughout history.
These esteemed institutions illustrate that there is hope on the horizon for those grappling with unrelenting nerve pain - an affliction that affects countless individuals worldwide. Through pioneering research efforts taking place across these diverse locations nationwide,fresh insightsare continually being gained into this intricate condition.These invaluable initiatives bring us closer than ever before discovering novel treatments aimed at alleviating suffering endured by those affected by chronic neuropathy. With ongoing dedication and breakthroughs, these hospitals are paving the way towards a brighter, pain-free future for individuals grappling with nerve pain.
Which are the best cities for nerve pain clinical trials?
When it comes to nerve pain clinical trials, several cities in the United States stand out as hubs of research and development. Boston, Massachusetts leads the way with 11 active trials investigating treatments like Gabapentin and Qutenza. Houston, Texas follows closely behind with 10 ongoing studies focused on interventions such as Tetrodotoxin for injection. Miami, Florida also plays a significant role in nerve pain research with 8 active trials exploring options like Transcranial direct electrical stimulation. These cities, along with Chicago and New york City, offer individuals suffering from nerve pain opportunities to participate in cutting-edge clinical trials that may lead to improved management and relief of their symptoms.
Which are the top treatments for nerve pain being explored in clinical trials?
Exciting developments in clinical trials are shedding light on the top treatments being explored for nerve pain. [18F]FTC-146, a promising drug, is currently undergoing testing in two active trials dedicated to nerve pain. First introduced in 2018, it has already accumulated an impressive record of two all-time trials focused on tackling this challenging condition. Another notable contender is spinal cord stimulation, with two ongoing trials and a total of five historical studies addressing nerve pain since its introduction in 2014. Lastly, ketamine infusion shows promising potential as a treatment option for nerve pain and is currently being investigated in one active trial after making its first appearance on the scene in 2021. These innovative approaches offer hope for individuals struggling with debilitating nerve pain and may pave the way towards improved quality of life.
What are the most recent clinical trials for nerve pain?
Exciting developments in the field of nerve pain management have emerged from recent clinical trials. Among them, RTA 901, a groundbreaking treatment for nerve pain, has entered Phase 2 testing and shows promise in providing relief. Additionally, Gabapentin and THC (Dronabinol) have both progressed to Phase 3 and Phase 2 respectively as potential therapies for alleviating nerve pain. CBD/PEA is also being explored in Phases 1 and 2 studies with encouraging results thus far. Lastly, AFA-281 has initiated its Phase 1 trial targeting nerve pain management. These advancements signify significant progress towards improved treatments for individuals suffering from this debilitating condition.
What nerve pain clinical trials were recently completed?
Several clinical trials focusing on nerve pain have recently concluded, offering potential advancements in the management of this debilitating condition. In January 2022, Eli Lilly and Company successfully completed a trial investigating LY3526318's efficacy in addressing nerve pain. Preceding this, Lexicon Pharmaceuticals wrapped up their LX9211 trial in December 2020. Furthermore, November 2020 saw the completion of a trial for ETX-018810 conducted by Eliem Therapeutics (UK) Ltd., while Seema Capoor's Naloxone Hydrochloride 0.4 MG/ML study reached its conclusion in October 2020. These recent developments contribute to our understanding and treatment options for nerve pain, signifying progress towards improving patients' quality of life.