Your session is about to expire
Prozac vs Cymbalta
Introduction
For patients dealing with major depressive disorder (MDD) or other forms of depression, certain drugs that modify the levels of specific compounds in the brain linked to mood, known as neurotransmitters, can assist in stabilizing depressive lows and managing symptoms. Prozac and Cymbalta are two such drugs often prescribed for handling depression. They both impact different neurotransmitters within our brains but have similar mood-stabilizing effects on patients suffering from depression. Prozac is classified as a selective serotonin reuptake inhibitor (SSRI), which primarily influences levels of serotonin. On the contrary, Cymbalta falls under both categories: a serotonin-norepinephrine reuptake inhibitor (SNRI), affecting not just serotonin but also norepinephrine concentrations in the brain.
Prozac vs Cymbalta Side By Side
| Attribute | Prozac | Cymbalta |
|---|---|---|
| Brand Name | Prozac | Cymbalta |
| Contraindications | Should not be taken with or within 5 weeks of using MAO inhibitors. | Should not be taken with or within 5 weeks of using MAO inhibitors. |
| Cost | For the brand name, about $570 for 30 capsules (20 mg). For the generic (fluoxetine), costs can be as low as about $0.05/day to about $1.00/day. | For the brand name, about $230 for 30 capsules (60 mg). For the generic (duloxetine), costs range between $0.15 and $1.00 per day. |
| Generic Name | Fluoxetine | Duloxetine |
| Most Serious Side Effect | An increase in suicidal thoughts or tendencies, severe skin reactions, visual disturbances, cardiovascular issues, low sodium levels, severe nervous system reaction. | Signs of an allergic reaction, severe skin reactions, increased risk of suicidal thoughts, changes in behavior or mood swings, difficulty concentrating, unexplained weight loss, high levels of serotonin, vision changes. |
| Severe Drug Interactions | MAO inhibitors. | MAO inhibitors. |
| Typical Dose | Oral dosages range from 20-60 mg/day, with a maximum dosage not to exceed 120 mg/day. | Begins at a dosage of 30-60 mg/day, with a maximum recommended dose of 120 mg/day for certain conditions. |
What is Prozac?
Duloxetine (the generic name for Cymbalta) was introduced as a novel drug of the SNRI class of antidepressants, which presented an advancement from the first SSRI class. Duloxetine was first approved by the FDA in 2004. Cymbalta increases levels of both serotonin and norepinephrine by inhibiting their reuptake into cells in the brain, thereby enhancing neurotransmission. It is prescribed for various conditions including depression, generalized anxiety disorder, fibromyalgia and neuropathic pain. Unlike Prozac that has a selective influence on serotonin with minor effects on dopamine and norepinephrine, Cymbalta affects both these neurotransmitters significantly along with serotonin. Therefore, it may have different side effects compared to those experienced with Prozac.
What conditions is Prozac approved to treat?
Cymbalta is approved for the treatment of several mental and physical health conditions, which include:
- Major depressive disorder (MDD), also known as unipolar depression
- Generalized anxiety disorder (GAD)
- Diabetic peripheral neuropathic pain
- Fibromyalgia
- Chronic musculoskeletal pain
How does Prozac help with these illnesses?
Cymbalta, like Prozac, is also used in the management of depression. However, it works slightly differently in that it increases both serotonin and norepinephrine levels within the brain's synapses. It blocks these neurotransmitters from being reabsorbed by neurons, hence maintaining their higher concentration for extended periods. Both serotonin and norepinephrine are chemical messengers which play significant roles not only in mood regulation but also cognition, memory, sleep patterns amongst others. Norepinephrine additionally plays a role in attentiveness and responding actions to stressful situations. Therefore individuals with depression may have relatively lower levels of both these neurotransmitters; thus increasing them can help manage depressive symptoms more effectively and stabilize mood swings better than increasing just one neurotransmitter alone could achieve.
What is Cymbalta?
Cymbalta, also known by its generic name duloxetine, is a serotonin-norepinephrine reuptake inhibitor (SNRI). This means it increases the levels of both serotonin and norepinephrine in the brain by reducing their reabsorption. It can also mildly inhibit the reuptake of dopamine but not to an extent that would significantly affect dopamine levels. Cymbalta was first approved by the FDA in 2004. Unlike Prozac, an SSRI antidepressant which primarily impacts serotonin levels, Cymbalta's action on both serotonin and norepinephrine may provide broader symptom relief for those suffering from depression or anxiety disorders. Additionally, because it affects two neurotransmitters instead of one like Prozac does with only serotonin, Cymbalta has been found effective in managing neuropathic pain associated with diseases such as fibromyalgia and diabetic peripheral neuropathy - conditions where Prozac generally isn't used. While side effects like nausea and dry mouth are common for both drugs due to their influence on serotonin receptors, Cymbalta may cause increased sweating due to its impact on norepinephrine levels.
What conditions is Cymbalta approved to treat?
Cymbalta is approved by the FDA for the treatment of several conditions, including:
- Major depressive disorder (MDD)
- Generalized anxiety disorder (GAD)
- Diabetic peripheral neuropathy pain
- Fibromyalgia
- Chronic musculoskeletal pain
How does Cymbalta help with these illnesses?
Duloxetine, commonly known as Cymbalta, is a medication that operates on two neurotransmitters: serotonin and norepinephrine. These chemicals are integral to mood regulation, pain perception, and overall brain function. Like Prozac - an SSRI that primarily increases the levels of serotonin in the brain - Cymbalta also enhances serotonin availability. However, it goes a step further by additionally boosting the presence of norepinephrine. This dual action can offer broad symptom relief for those dealing with depression or anxiety disorders.
Cymbalta's influence on norepinephrine may assist in managing symptoms linked to low energy or concentration problems often reported in depressive conditions. Additionally, its impact on both serotonin and norepinephrine makes it effective against certain types of chronic pain such as fibromyalgia or neuropathic pain associated with diabetes. It is sometimes prescribed when patients do not respond well enough to typical SSRIs like Prozac alone or used alongside other medications for a more comprehensive treatment approach.
How effective are both Prozac and Cymbalta?
Both fluoxetine (Prozac) and duloxetine (Cymbalta) have proven histories of efficacy in managing depression, initially getting FDA approval just a few years apart. They work on different neurotransmitters and may be prescribed depending on varying circumstances. A 2008 study directly compared the effectiveness of fluoxetine with that of duloxetine, showing both drugs to exhibit similar capabilities in alleviating depressive symptoms and comparable safety profiles. This study found no significant differences between patients receiving Prozac or those taking Cymbalta when evaluating various metrics used to measure treatment effects.
A review conducted in 2010 based on several meta-analyses showed Prozac’s ability to improve depressive symptoms starting from the first week of treatment; it also highlighted its favorable side effect profile over many other antidepressants. The drug was reported as well-tolerated across diverse populations, including elderly and pregnant individuals, reinforcing its position as one of the most widely-prescribed antidepressants worldwide.
On the other hand, a 2016 review and meta-analysis indicated that Cymbalta appears more effective than placebo for treating depression, while demonstrating an efficacy comparable to commonly-used antidepressants. Despite this evidence, Duloxetine is often considered a second-line treatment option—usually employed only after SSRIs haven’t worked or have caused unwanted side effects. While most research involves using Cymbalta alongside another SSRI rather than standalone usage , it remains an optimal choice for patients who didn't respond well to SSRIs or wish to avoid their common adverse effects such as sexual dysfunction or weight gain.
Find Top Clinical Trials
Choose from over 30,000 active clinical trials.
At what dose is Prozac typically prescribed?
Oral dosages of Cymbalta range from 20-60 mg/day, but research suggests that a daily dose of 40-60mg is usually effective for managing major depressive disorder in most adults. Children and adolescents may be started on lower doses as determined by their healthcare provider based on body weight and response to the medication. In either population, dosage can be increased after a few weeks if there is no significant improvement. However, the maximum dosage should not exceed 120 mg/day under any circumstances.
At what dose is Cymbalta typically prescribed?
Cymbalta treatment typically begins at a dosage of 30-60 mg/day. If necessary, the dosage can be increased to 60 mg per day after one week. This is generally taken as a single dose but may be divided into two doses if directed by your doctor. For some conditions, such as fibromyalgia or generalized anxiety disorder, the maximum recommended dose is 120 mg/day, which would usually be divided into two equal doses of 60 mg each and spaced about twelve hours apart. It's important to note that this higher dose should only be considered if there has been no significant response to treatment at the standard dose of 60mg/day after several weeks.
What are the most common side effects for Prozac?
Choosing between Prozac and Cymbalta can be challenging as both medications have their own set of side effects. Common side effects of Prozac include anxiety, nervousness, insomnia, somnolence (sleepiness), asthenia (general weakness), tremor, anorexia, nausea, dyspepsia (discomfort in the digestive tract), and diarrhea. On the other hand, the side effects associated with Cymbalta are similar but may also include dry mouth, decreased libido (sex drive), abnormal ejaculation or orgasmic function changes in women including impotence for men. Both medications can cause sweating and skin rash. However, it's worth noting that abnormal dreams are more common with Cymbalta than Prozac while flu-like symptoms appear to be less frequent. Pharyngitis and sinusitis occur infrequently with both drugs; however yawning is a unique side effect observed predominantly in patients on Prozac treatment.
Are there any potential serious side effects for Prozac?
While comparing Prozac to Cymbalta, it's essential to be aware of potential side effects that can occur. In rare cases, these may include:
- An increase in suicidal thoughts or tendencies
- Signs of an allergic reaction such as hives, difficulty breathing, facial swelling or throat swelling. You might also experience a fever, sore throat, burning eyes and skin pain.
- Severe skin reactions including a red or purple rash that blisters and peels
- Visual disturbances like blurred vision or tunnel vision, eye pain or swelling; you could even see halos around lights.
- Cardiovascular issues like fast heartbeats causing fluttering in your chest which could result in shortness of breath and sudden dizziness.
- Low sodium levels leading to headaches, confusion and slurred speech. Other symptoms could be severe weakness accompanied by vomiting and loss of coordination making you feel unsteady.
- A severe nervous system reaction - this can make your muscles very stiff (rigid) while causing high fever with sweating. It is associated with confusion along with fast uneven heartbeats when tremors are experienced as if feeling like passing out.
Moreover, any symptoms related to serotonin syndrome should prompt immediate medical attention: agitation combined with hallucinations; fever plus excessive sweating; shivering alongside fast heart rate; muscle stiffness accompanied by twitching resulting in loss of coordination together with nausea ending up in vomiting coupled with diarrhea. If any such symptom is observed post intake of either drug then the usage must be stopped immediately followed by contacting your healthcare provider for further instructions on how to proceed safely.
What are the most common side effects for Cymbalta?
Cymbalta, similar to Prozac, can cause a variety of side effects. These include:
- Dry mouth and throat
- Constipation
- Nausea and loss of appetite
- Sleep problems (insomnia)
- Excessive sweating
- Feelings of anxiety or nervousness
- Increased heart rate
- Muddled cognition, restlessness, or hostility in rare cases
- Skin rash on occasion
- Potential weight loss
- Frequent urination in some instances
-Dizziness or headaches are also common
-In certain situations it may induce muscle or joint pain
However, the severity and frequency of these side effects vary from person to person. Always consult with your healthcare provider when starting a new medication like Cymbalta.
Are there any potential serious side effects for Cymbalta?
While Cymbalta is generally well-tolerated, it can cause severe side effects in some individuals. These may include:
- Signs of an allergic reaction such as hives, difficulty breathing, swelling of your face or throat
- Severe skin reactions including fever, sore throat, burning eyes, skin pain followed by a red or purple skin rash that spreads and causes blistering and peeling
- Increased risk of suicidal thoughts especially among those under 24 years during the initial treatment phase
- Changes in behavior or mood swings with signs of anxiety and agitation
- Difficulty concentrating; confusion; memory problems
- Unexplained weight loss
- High levels of serotonin manifested as hallucinations, rapid heartbeat, fever etc.
- Vision changes like blurred vision or seeing halos around lights
If you experience any sudden change in behavior or unusual symptoms while on Cymbalta therapy consult your healthcare provider immediately.
Contraindications for Prozac and Cymbalta?
Both Cymbalta and Prozac, like many other antidepressant medications, may exacerbate symptoms of depression in certain individuals. If you find your depression intensifying or notice an increase in suicidal thoughts or behaviors, it's crucial to seek immediate medical attention.
Neither Cymbalta nor Prozac should be taken if you are currently using or have recently discontinued monoamine oxidase (MAO) inhibitors. It's vital to inform your healthcare provider about all the medicines you're taking; MAOIs necessitate a washout period of approximately 5 weeks to prevent perilous interactions with both Prozac and Cymbalta.
How much do Prozac and Cymbalta cost?
For the brand name versions of these drugs:
- The price of 30 capsules of Cymbalta (60 mg) averages around $230, which works out to approximately $7.67/day.
- The price of 30 capsules of Prozac (20 mg) averages about $570, working out to approximately $19/day.
Thus, if you are in the higher dosage range for Prozac (i.e., 40 mg/day or higher), then brand-name Cymbalta is less expensive on a per-day treatment basis. Please note that cost should not be a primary consideration in determining which of these drugs is right for you.
For the generic versions of Prozac (fluoxetine) and Cymbalta (duloxetine), costs are significantly lower:
- Duloxetine is available in packs from 10 up to several hundred capsules with average costs between $0.15 and $1.00 per day depending on your dosage and where you purchase it.
- Fluoxetine can be had from as low as about $0.05/day when buying larger quantities upfront and does not typically exceed about a dollar per day even at more typical retail prices/purchasing practices.
Popularity of Prozac and Cymbalta
Fluoxetine, available under the brand name Prozac among others, was prescribed to about 4.7 million individuals in the US in 2020. Representing just under 20% of SSRI prescriptions and nearly 10% of all antidepressant prescriptions, fluoxetine has maintained a steady presence for the past decade.
On the other hand, Duloxetine, marketed as Cymbalta among several other trade names, was estimated to have been prescribed to around 6.3 million people in the US during that same period. Accounting for approximately 13% of SNRI (Serotonin–norepinephrine reuptake inhibitor) prescriptions and about 14% of overall antidepressant prescriptions in America. The usage rates for duloxetine have increased since its introduction to the market due to its dual action on serotonin and norepinephrine neurotransmitters which can be beneficial for managing certain neuropathic pain conditions along with depression and anxiety disorders.
Conclusion
Both Prozac (fluoxetine) and Cymbalta (duloxetine) have long-standing records of usage in patients with depression, and are backed by numerous clinical studies indicating that they are more effective than placebo treatments. In some cases, the drugs may be combined, but this is subject to careful consideration by a physician as they can also interact negatively with one another. Due to their different mechanisms of action, with Prozac acting primarily on serotonin reuptake inhibition, and Cymbalta inhibiting both serotonin and norepinephrine reuptake, they tend to be prescribed under different circumstances. Prozac is often considered a first-line treatment option for major depressive disorder while Cymbalta might be chosen for its additional benefits in managing neuropathic pain associated conditions like fibromyalgia or diabetic peripheral neuropathy.
Both drugs are available in generic form which represents significant cost savings especially for patients who must pay out of pocket. Both Prozac and Cymbalta may require an adjustment period; it's important to note that effects may not be noticeable right away.
The side effect profile between the two drugs varies; both being generally well-tolerated but Cymbalta has been associated more frequently with side effects such as dry mouth, constipation and excessive sweating compared to Prozac. For both medications though patients must closely monitor their moods especially when starting treatment – any worsening depression or emergence of suicidal thoughts should prompt immediate contact with healthcare providers.
Other Trials to Consider
Popular Categories
Popular Guides
Learn More About These Treatments
Refrences
- Frampton, J. E., & Plosker, G. L. (2007). Duloxetine. CNS Drugs. Springer Science and Business Media LLC.http://doi.org/10.2165/00023210-200721070-00004
- Smith, T. R. (2006, January 24). Duloxetine in diabetic neuropathy. Expert Opinion on Pharmacotherapy. Informa Healthcare.http://doi.org/10.1517/14656566.7.2.215
- Bellingham, G. A., & Peng, P. W. H. (2010, May). Duloxetine. Regional Anesthesia and Pain Medicine. BMJ.http://doi.org/10.1097/aap.0b013e3181df2645
- Eckert, L., & Lançon, C. (2006, July 24). Duloxetine compared with fluoxetine and venlafaxine: use of meta-regression analysis for indirect comparisons. BMC Psychiatry. Springer Science and Business Media LLC.http://doi.org/10.1186/1471-244x-6-30
- Prakash, A., Lobo, E., Kratochvil, C. J., Tamura, R. N., Pangallo, B. A., Bullok, K. E., … March, J. S. (2012, February). An Open-Label Safety and Pharmacokinetics Study of Duloxetine in Pediatric Patients with Major Depression. Journal of Child and Adolescent Psychopharmacology. Mary Ann Liebert Inc.http://doi.org/10.1089/cap.2011.0072
- Kusturica, J., Zulić, I., Loga-Zec, S., Mulabegović, N., Loga, S., & Kapić, E. (2002, February 20). Frequency and characteristics of side effects associated with antidepressant drugs. Bosnian Journal of Basic Medical Sciences. Association of Basic Medical Sciences of FBIH.http://doi.org/10.17305/bjbms.2002.3575
- Soleymani, F., Taheri, F., Roughead, E., Nikfar, S., & Abdollahi, M. (2018). Pattern of Antidepressant Utilization and Cost in Iran from 2006 to 2013 in Comparison with Other Countries. Journal of Epidemiology and Global Health. Springer Science and Business Media LLC.http://doi.org/10.2991/j.jegh.2018.06.101