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What is Asendin
AmoxapineThe Generic name of this drug
Treatment SummaryAmoxapine is an antidepressant medication that belongs to a class of drugs called tricyclic antidepressants (TCAs). TCAs work by increasing levels of serotonin and norepinephrine, two chemicals in the brain that can improve mood. Amoxapine can be used to treat depression and anxiety, and it may cause sedation in people who are not depressed. Common side effects include blurred vision, dry mouth, constipation, and urinary retention.
Amoxapineis the brand name
Asendin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Amoxapine
Amoxapine
1992
5
Effectiveness
How Asendin Affects PatientsAmoxapine is an antidepressant drug that works differently than other antidepressants. It has a calming effect, and the way it affects the body is not fully understood. In animals, Amoxapine has been shown to reduce the uptake of certain chemicals (nor-epinephirine and serotonin) and block the effect of dopamine. It does not work by blocking an enzyme like some other antidepressants. Studies suggest that Amoxapine works faster than other types of antidepressants.
How Asendin works in the bodyAmoxapine works by blocking the absorption of two brain chemicals, norepinephrine and serotonin.
When to interrupt dosage
The prescribed dosage of Asendin is contingent upon the diagnosed condition, for example Neurotic depression, Psychotic Depression and Agitation. The magnitude of dosage fluctuates, conforming to the technique of delivery (e.g. Oral or Tablet) highlighted in the depicted table.Condition
Dosage
Administration
Depression
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Generalized Anxiety Disorder
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Agitation
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Mental Depression
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Psychotic Depression
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Mental Depression
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Neurotic depression
, 50.0 mg, 25.0 mg, 100.0 mg, 150.0 mg
, Oral, Tablet, Tablet - Oral
Warnings
Asendin ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Asendin Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Amoxapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Amoxapine is combined with Aclidinium.
Alfuzosin
Major
Amoxapine may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Amoxapine may increase the antipsychotic activities of Amisulpride.
Aripiprazole
Major
Amoxapine may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Asendin Toxicity & Overdose RiskTaking too much of the medication amoxapine can lead to seizures, coma, and acidosis. In some cases, kidney failure may occur two to five days after an overdose. In rare cases, kidney failure may be accompanied by muscle breakdown, pain, and discolored urine.
Asendin Novel Uses: Which Conditions Have a Clinical Trial Featuring Asendin?
819 clinical trials are in progress to ascertain the potential of Asendin to ameliorate Neurotic Depression, Agitation and Mental Depression.Condition
Clinical Trials
Trial Phases
Psychotic Depression
0 Actively Recruiting
Generalized Anxiety Disorder
220 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 1
Mental Depression
0 Actively Recruiting
Mental Depression
0 Actively Recruiting
Neurotic depression
0 Actively Recruiting
Depression
338 Actively Recruiting
Phase 1, Phase 2, Early Phase 1, Not Applicable, Phase 4, Phase 3
Agitation
4 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Asendin Reviews: What are patients saying about Asendin?
5Patient Review
6/9/2009 I was on this medication for 3 years and it did help me, though I'm not sure why my doctor decided to take me off of it.
5Patient Review
7/4/2017 I find amaoxopine to be much more effective for anxiety than Benzodiazepines, which build up a tolerance over time. I feel so much better now that I've switched.
3.3Patient Review
12/20/2010 I'm still not entirely sure if this is the right medication for me. I'm looking for an antidepressant that helps with dopamine and norepinephrine production, since SSRIs don't seem to work well with my brain chemistry.
Patient Q&A Section about asendin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does amoxapine take to work?
"This medication doesn't work immediately. It could take up to two weeks for you to experience the full benefits."
Answered by AI
What is asendin used for?
"This medication is used to treat depression by restoring the balance of natural chemicals (neurotransmitters) in the brain."
Answered by AI
Is amoxapine an antipsychotic drug?
"Although it is marketed as an antidepressant, amoxapine's in-vitro profile, receptor occupancy and preclinical effects are very similar to those of atypical antipsychotics. Amoxapine has also shown efficacy as an atypical antipsychotic in open trials."
Answered by AI
Can amoxapine make you sleepy?
"Amoxapine can cause drowsiness, so it is best to take it at night, especially when you first start taking it. In the beginning, you might need to take smaller doses multiple times a day so your body can get used to the medication."
Answered by AI