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What is Bumex
BumetanideThe Generic name of this drug
Treatment SummaryBumetanide is a type of medication that increases the amount of urine produced by the body. It is used to treat a range of medical conditions that involve excess fluid in the body.
Bumexis the brand name
Bumex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Bumex
Bumetanide
1983
144
Approved as Treatment by the FDA
Bumetanide, also known as Bumex, is approved by the FDA for 4 uses which include Liver Diseases and Chronic Kidney Disease (CKD) .Liver Diseases
Helps manage Hepatic Disease
Chronic Kidney Disease (CKD)
Helps manage Kidney Diseases
Swollen feet or ankles
Helps manage Edema
Congestive Heart Failure
Helps manage Heart Failure
Effectiveness
How Bumex Affects PatientsBumetanide is a type of diuretic drug used to treat heart failure. It can be used as the first choice for treatment, as it is more predictable and effective than furosemide. Bumetanide is 40 times more effective than furosemide in patients with normal kidney function.
How Bumex works in the bodyBumetanide helps the body get rid of excess water and salt by preventing the kidneys from reabsorbing them. It does this by blocking the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, which changes how the kidneys process electrolytes. This leads to the excretion of sodium, chloride, and water, resulting in diuresis.
When to interrupt dosage
The advised dosage of Bumex is contingent upon the determined condition, including Congestive Heart Failure, Edema and Hepatic Disease. The amount of dosage depends on the technique of delivery (e.g. Tablet - Oral or Oral) specified in the table below.Condition
Dosage
Administration
Swollen feet or ankles
, 0.5 mg, 1.0 mg, 2.0 mg, 0.25 mg/mL, 5.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intravenous
Congestive Heart Failure
, 0.5 mg, 1.0 mg, 2.0 mg, 0.25 mg/mL, 5.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intravenous
Chronic Kidney Disease (CKD)
, 0.5 mg, 1.0 mg, 2.0 mg, 0.25 mg/mL, 5.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intravenous
Liver Diseases
, 0.5 mg, 1.0 mg, 2.0 mg, 0.25 mg/mL, 5.0 mg
, Oral, Tablet, Tablet - Oral, Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection, solution, Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intravenous
Warnings
Bumex ContraindicationsCondition
Risk Level
Notes
marked increase in blood urea nitrogen
Do Not Combine
Hepatic Encephalopathy
Do Not Combine
increased serum creatinine
Do Not Combine
severe electrolyte depletion
Do Not Combine
Oliguria
Do Not Combine
Anuria
Do Not Combine
Common Bumex Drug Interactions
Drug Name
Risk Level
Description
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Bumetanide is combined with Cyclopentamine.
Hexamethonium
Major
The risk or severity of adverse effects can be increased when Bumetanide is combined with Hexamethonium.
Mecamylamine
Major
The risk or severity of adverse effects can be increased when Bumetanide is combined with Mecamylamine.
Methotrexate
Major
The risk or severity of adverse effects can be increased when Bumetanide is combined with Methotrexate.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Bumetanide is combined with Neomycin.
Bumex Toxicity & Overdose RiskTaking too much of this drug can cause severe fluid and electrolyte loss, dehydration, reduced blood volume, and even collapse due to a decrease in circulation. Other symptoms of an overdose include weakness, dizziness, confusion, lack of appetite, fatigue, vomiting, and cramping. Treatment should involve carefully monitoring urine and electrolyte levels and replacing lost fluids and electrolytes.
Bumex Novel Uses: Which Conditions Have a Clinical Trial Featuring Bumex?
At present, 579 active clinical trials are assessing the potential of Bumex to ameliorate Kidney Disease, Liver Disease and Edema.Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease (CKD)
27 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 4, Phase 1
Liver Diseases
0 Actively Recruiting
Congestive Heart Failure
181 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Swollen feet or ankles
6 Actively Recruiting
Phase 2, Not Applicable
Bumex Reviews: What are patients saying about Bumex?
5Patient Review
6/7/2013 I began taking Bumetanide today and it's already been very effective. I haven't had any negative side effects, which is a relief after my experience with furosemide.
5Patient Review
6/2/2013 Unfortunately, this medication caused me an intense amount of pain that made it difficult to move. I also experienced serious swelling in my lower extremities. Needless to say, I won't be taking it again.
5Patient Review
6/8/2013 I experienced great results for the first week or so. However, I began to experience muscle soreness and weight gain again. Additionally, I felt dizzy. This treatment was no better than Lasix for me.
5Patient Review
4/3/2014 The spasms have become unbearable and, at times, I can't use my fingers because they twist up and hurt so badly! I've had so many reactions that I don't even know where to start.My doctor did some blood work and everything came back normal.
5Patient Review
6/2/2013 Unfortunately, I had to stop taking this medication after just two days. The muscle and joint pain was unbearable and my legs were still swollen.
5Patient Review
4/3/2014 The spasms have become really intense and at times I can't even use my fingers because they contort and hurt so badly. I've had so many reactions to this that I don't even know where to start. My doctor did some blood work and everything came back normal.
5Patient Review
6/7/2013 Bumetanide is working great for me so far. I'm using the restroom more frequently, but that's to be expected. Furosemide didn't work well for me and made me feel awful from the start, in contrast to Bumetanide.
5Patient Review
6/8/2013 This treatment was great for the first week or so, but then I started experiencing muscle soreness, weight gain, and dizziness. No better than Lasix, in my opinion.
5Patient Review
5/28/2014 Even when I cut the dosage in half, I found that I was urinating excessively.
5Patient Review
11/24/2014 I sweat profusely while taking this medication. It was so bad that I would be sitting and the water would just run off my neck and head.
5Patient Review
5/10/20115Patient Review
3/4/20125Patient Review
11/24/2014 I was sweating excessively while using this medication. It would be dripping off my head and neck even when I wasn't doing anything physical.
5Patient Review
5/28/2014 Even when I halved the dosage, I found that I was urinating excessively.
5Patient Review
5/10/20115Patient Review
3/4/20124.7Patient Review
8/15/20124.7Patient Review
8/15/20123.7Patient Review
9/3/2014 My dad took one pill a day for six days and saw some great results. He lost about 40 pounds in two-and-a-half weeks and feels much better now. He's even able to walk without a walker and put his shoes on by himself!
3.7Patient Review
9/16/2013 I dropped 23 pounds of water weight in just one week thanks to this treatment! It's also worth noting that my shoes now fit comfortably.
3.7Patient Review
9/3/2014 My dad took this medication and it resulted in some serious weight loss - 40 pounds in just 2.5 weeks! He feels much better now and is even able to walk without a cane or help getting his shoes on.
3.7Patient Review
9/16/2013 I've only been using this treatment for a week and I've already dropped 23 pounds of water weight. The swelling is gone and I can wear shoes comfortably again.
3.7Patient Review
2/18/2018 She also has high blood pressure. How much more extra fluid should she drink due to the water loss?
3.7Patient Review
2/18/2018 My grandmother also has high blood pressure. How much more water should she drink due to the diuretic effect?
2.7Patient Review
12/6/2013 I've now been taking Bumex for a month, and while there's been some reduction in the swelling of my feet, it hasn't completely gone away. I started with a lower dose which I took twice daily for two weeks before increasing to the current dosage.
2.7Patient Review
12/6/2013 Bumex hasn't helped me lose any water weight, unfortunately. And while it has decreased the swelling in my feet somewhat, they're still not back to normal.
2.3Patient Review
10/19/2012 I had started to see some improvement after only taking Bumetanide-oral for a day, but it will still be awhile before my ankles are back to normal.
2.3Patient Review
10/19/2012 I had been experiencing severe swelling and water retention in my lower legs, but after starting to take Bumetanide-oral, I saw some improvement within just a day. It'll still be a little while before everything is back to normal, but I'm pleased with the medication nonetheless.
2Patient Review
10/28/2013 I started taking bumetanide and immediately began feeling bad. Low energy, less urination, dark urine. The doctor suggested doubling the dose, but I refused because I didn't want to feel worse. He prescribed some vitamins and told me to come back in five weeks.
2Patient Review
10/28/2013 I had renal failure 15 years ago and started taking bumetanide. I immediately started feeling bad - low energy, less urination, dark urine, cloudy to dark urine. The doctor suggested doubling the dose to two pills twice a day. I told him that I would no longer be taking pills that made me feel worse or even bad. He prescribed vitamins and told me to come back in five weeks. It seems I am in the market for a new doctor.
1Patient Review
7/15/2013 I started taking this medication on Friday and have already seen a significant difference. The water weight loss is great, but I also feel more energetic and my legs don't hurt as much. Lasic didn't do anything for me except give me terrible leg cramps.
1Patient Review
7/15/2013 I started taking this medication on Friday, May 31st and I have already lost five pounds of water weight. I'm feeling really good and the tightness in my legs is getting better. Lasic didn't work for me at all, except to cause bad leg cramps. So far, I'm really pleased with this drug.
1Patient Review
2/16/2013 Bumetanide really helped with my water retention. I was so swollen I couldn't even lift my feet, but now I'm feeling much better and stronger thanks to this medication and some physical therapy.
1Patient Review
5/3/20121Patient Review
2/16/2013 The water retention was so bad that I could not even lift my feet. Bumetanide has helped me a lot, but I've also been doing physical therapy to regain my strength.
1Patient Review
5/3/2012Patient Q&A Section about bumex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Bumex stronger than Lasix?
"The drug Bumex is more potent than Lasix, with Bumex being 40 times more potent than Lasix for people with normal kidney function."
Answered by AI
What is Bumex given for?
"Bumetanide is a diuretic that is used to remove excess fluid from the body. It is used to treat conditions such as heart failure, liver disease, and kidney disease. Bumetanide works by increasing the amount of urine produced by the kidneys, which helps to remove excess fluid from the body."
Answered by AI
Does Bumex lower potassium?
"Bumex may also reduce the level of potassium in your blood. This drug should only be used when it is absolutely necessary during pregnancy."
Answered by AI
Is Bumex harmful to kidneys?
"Drugs that have the potential to be toxic to the kidneys are called nephrotoxic drugs. Lithium is a nephrotoxic drug. Diuretics such as bumetanide lower the clearance of lithium in the kidneys, which increases the risk of lithium toxicity."
Answered by AI