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What is Chronulac
LactuloseThe Generic name of this drug
Treatment SummaryLactulose is a synthetic sugar-based drug used to treat constipation and portal-systemic encephalopathy (PSE). It was first synthesized in 1929, but it wasn't until the 1960s that its use as a laxative was investigated. It was approved by the FDA in 1977 and is now available over-the-counter. While it is an effective and safe option for treating constipation and PSE, its exact effectiveness is not clear. It is typically only used after lifestyle and dietary modifications have failed.
Lactuloseis the brand name
Chronulac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lactulose
Lactulose
1966
63
Approved as Treatment by the FDA
Lactulose, also known as Lactulose, is approved by the FDA for 3 uses which include Constipation and Hepatic Encephalopathy .Constipation
Hepatic Encephalopathy
Hepatic Encephalopathy
Effectiveness
How Chronulac Affects PatientsLactulose is a laxative commonly taken by mouth or rectally. It stays in the gastrointestinal tract and helps to soften stools and increase their volume, which can cause increased bowel sounds, bloating, burping, gas, and diarrhea.
How Chronulac works in the bodyLactulose is a medication that helps people with constipation and portal-systemic encephalopathy (PSE). It works by breaking down into organic acids in the large intestine and creating gas which increases the water content of the stool, making it softer and easier to pass. It can take 24-48 hours for the laxative effects to be evident. For PSE, Lactulose also creates an acidic environment in the colon which prevents absorbed ammonia from entering the bloodstream by turning it into ammonium ions. This prevents excess ammonia from building up in the body, and also causes urease-producing bacteria to be eliminated
When to interrupt dosage
The measure of Chronulac is reliant upon the diagnosed affliction, including Hepatic Encephalopathy, Chronic Constipation and Hepatic Encephalopathy. The amount of dosage is contingent on the method of delivery (e.g. Oral or Solution) outlined in the table below.Condition
Dosage
Administration
Constipation
, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg
, Oral, Solution, Solution - Oral, Oral; Rectal, Solution - Oral; Rectal, Powder, for solution - Oral, Powder, for solution, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Syrup - Oral; Rectal, Liquid - Oral; Rectal
Hepatic Encephalopathy
, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg
, Oral, Solution, Solution - Oral, Oral; Rectal, Solution - Oral; Rectal, Powder, for solution - Oral, Powder, for solution, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Syrup - Oral; Rectal, Liquid - Oral; Rectal
Hepatic Encephalopathy
, 1000.0 mg/mL, 2000.0 mg/mL, 1.0 mg/mg, 2.0 mg/mg, 667.0 mg, 667.0 mg/mL, 3300.0 mg/mL, 0.95 mg/mg
, Oral, Solution, Solution - Oral, Oral; Rectal, Solution - Oral; Rectal, Powder, for solution - Oral, Powder, for solution, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Syrup - Oral; Rectal, Liquid - Oral; Rectal
Warnings
Chronulac has two contraindications; therefore, it should not be ingested when encountering the conditions in the following table.Chronulac ContraindicationsCondition
Risk Level
Notes
low galactose diet
Do Not Combine
Pulse Frequency
Do Not Combine
Common Chronulac Drug Interactions
Drug Name
Risk Level
Description
Alloin
Minor
The risk or severity of adverse effects can be increased when Lactulose is combined with Alloin.
Bisacodyl
Minor
The risk or severity of adverse effects can be increased when Lactulose is combined with Bisacodyl.
Bisoxatin
Minor
The risk or severity of adverse effects can be increased when Lactulose is combined with Bisoxatin.
Calcium polycarbophil
Minor
The risk or severity of adverse effects can be increased when Lactulose is combined with Calcium polycarbophil.
Carboxymethylcellulose
Minor
The risk or severity of adverse effects can be increased when Lactulose is combined with Carboxymethylcellulose.
Chronulac Toxicity & Overdose RiskThe toxic dose of lactulose in mice is 48.8 mL/kg and more than 30 mL/ kg in rats. If someone overdoses on lactulose, they may experience abdominal cramps and diarrhea and should be given fluids and electrolytes as needed. It is not known if lactulose is safe to take during pregnancy or while nursing, so caution should be used. Studies in rats, mice, and rabbits have not shown any effects on fertility. Not enough data exists to say if it is safe to use in children or if it causes long-term mutations or cancer.
Chronulac Novel Uses: Which Conditions Have a Clinical Trial Featuring Chronulac?
25 active studies are examining the potential of Chronulac to manage Hepatic Encephalopathy, Chronic Constipation and Hepatic Encephalopathy related conditions.Condition
Clinical Trials
Trial Phases
Hepatic Encephalopathy
0 Actively Recruiting
Constipation
21 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Early Phase 1, Phase 3
Hepatic Encephalopathy
0 Actively Recruiting
Patient Q&A Section about chronulac
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does lactulose do to poop?
"Lactulose can help treat this condition by stopping the absorption of toxins from the bowel into the blood.
Lactulose is a type of laxative called an osmotic laxative. It is broken down by your digestive system into substances that draw water out of your body and into your digestive system to soften feces and make it easier to pass. People with liver disease can sometimes get problems in their brain (hepatic encephalopathy). Lactulose can help treat this condition by stopping the absorption of toxins from the digestive system into the bloodstream."
Answered by AI
Is lactulose a laxative?
"Lactulose is a laxative that comes from lactose. It's used to treat chronic constipation and hepatic encephalopathy or coma, which are brain disorders caused by liver disease."
Answered by AI
What is Chronulac used for?
"This laxative is used to treat constipation by increasing the number of bowel movements per day."
Answered by AI
What is Chronulac syrup generic name?
"The generic name for the medication lactulose is medically reviewed by Drugs.com as of June 8, 2022."
Answered by AI