Intralipid 20%
Nutritional supplementation, Parenteral Nutrition, Total, Parenteral Nutrition + 1 more
Treatment
1 FDA approval
2 Active Studies for Intralipid 20%
Treatment for
Nutritional supplementation
What is Intralipid 20%
Soybean oil
The Generic name of this drug
Treatment Summary
Soybean oil is a vegetable oil made from soybeans. It is made up of triglycerides and contains a mix of saturated, monounsaturated and polyunsaturated fatty acids. The major components of soybean oil are linoleic acid (48-58%), oleic acid (17-30%), palmitic acid (9-13%), linolenic acid (4-11%), and stearic acid (2.5-5.0%). It is used as a cooking oil and in clinical settings, it is used as a lipid emulsion for parenteral nutrition. Soybean oil-based lipid
Liposyn II
is the brand name
Intralipid 20% Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Liposyn II
Soybean oil
1984
19
Approved as Treatment by the FDA
Soybean oil, also known as Liposyn II, is approved by the FDA for 1 uses such as Parenteral Nutrition, Total .
Parenteral Nutrition, Total
Effectiveness
How Intralipid 20% Affects Patients
Soybean oil is a nutritious source of calories and fatty acids that the body can use. It helps to prevent any health issues caused by not having enough essential fatty acids and can help correct any symptoms related to this deficiency.
How Intralipid 20% works in the body
Soybean oil-based lipid emulsion is used for energy production. It breaks down into free fatty acids that can be used for energy and regulate gene expression. It also helps maintain a healthy liver by preventing triacylglycerol from accumulating, and regulating the production and breakdown of lipids. It can also help keep drug oxidation capabilities and antioxidant enzyme levels in the body steady.
When to interrupt dosage
The advised measure of Intralipid 20% is contingent upon the recognized condition, including Parenteral Nutrition, Nutritional supplementation and Parenteral Nutrition, Total. The amount of dosage is dictated by the delivery technique (e.g. Injection, emulsion or Intravenous) as presented in the table below.
Condition
Dosage
Administration
Nutritional supplementation
, 200.0 mg/mL, 10.0 %, 4.0 %, 20.0 %, 170.0 mg, 100.0 mg/mL, 30.0 %, 40.0 mg/mL, 916.0 mg/mL, 0.03 mg/mg, 300.0 mg/mL, 60.0 mg/mL, 5.0 %, 50.0 mg/mL, 35.0 mg/mL, 39.0 mg/mL, 8.5 mg/mL, 8.7 mg/mL, 11.4 mg/mL, 8.0 mg/mL, 6.0 mg/mL, 7.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Emulsion, Emulsion - Intravenous, Oral, Capsule, Capsule - Oral, Injection, emulsion - Intravenous, Injection, emulsion, Topical, Oil, Oil - Topical, Spray, Spray - Topical, Liquid, Liquid - Intravenous
Parenteral Nutrition, Total
, 200.0 mg/mL, 10.0 %, 4.0 %, 20.0 %, 170.0 mg, 100.0 mg/mL, 30.0 %, 40.0 mg/mL, 916.0 mg/mL, 0.03 mg/mg, 300.0 mg/mL, 60.0 mg/mL, 5.0 %, 50.0 mg/mL, 35.0 mg/mL, 39.0 mg/mL, 8.5 mg/mL, 8.7 mg/mL, 11.4 mg/mL, 8.0 mg/mL, 6.0 mg/mL, 7.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Emulsion, Emulsion - Intravenous, Oral, Capsule, Capsule - Oral, Injection, emulsion - Intravenous, Injection, emulsion, Topical, Oil, Oil - Topical, Spray, Spray - Topical, Liquid, Liquid - Intravenous
Parenteral Nutrition
, 200.0 mg/mL, 10.0 %, 4.0 %, 20.0 %, 170.0 mg, 100.0 mg/mL, 30.0 %, 40.0 mg/mL, 916.0 mg/mL, 0.03 mg/mg, 300.0 mg/mL, 60.0 mg/mL, 5.0 %, 50.0 mg/mL, 35.0 mg/mL, 39.0 mg/mL, 8.5 mg/mL, 8.7 mg/mL, 11.4 mg/mL, 8.0 mg/mL, 6.0 mg/mL, 7.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Emulsion, Emulsion - Intravenous, Oral, Capsule, Capsule - Oral, Injection, emulsion - Intravenous, Injection, emulsion, Topical, Oil, Oil - Topical, Spray, Spray - Topical, Liquid, Liquid - Intravenous
Ascorbic Acid Deficiency
, 200.0 mg/mL, 10.0 %, 4.0 %, 20.0 %, 170.0 mg, 100.0 mg/mL, 30.0 %, 40.0 mg/mL, 916.0 mg/mL, 0.03 mg/mg, 300.0 mg/mL, 60.0 mg/mL, 5.0 %, 50.0 mg/mL, 35.0 mg/mL, 39.0 mg/mL, 8.5 mg/mL, 8.7 mg/mL, 11.4 mg/mL, 8.0 mg/mL, 6.0 mg/mL, 7.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Emulsion, Emulsion - Intravenous, Oral, Capsule, Capsule - Oral, Injection, emulsion - Intravenous, Injection, emulsion, Topical, Oil, Oil - Topical, Spray, Spray - Topical, Liquid, Liquid - Intravenous
Warnings
Intralipid 20% Contraindications
Condition
Risk Level
Notes
Hyperlipidemia
Do Not Combine
Disease
Do Not Combine
There are 20 known major drug interactions with Intralipid 20%.
Common Intralipid 20% Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Minor
The therapeutic efficacy of (R)-warfarin can be decreased when used in combination with Soybean oil.
(S)-Warfarin
Minor
The therapeutic efficacy of (S)-Warfarin can be decreased when used in combination with Soybean oil.
4-hydroxycoumarin
Minor
The therapeutic efficacy of 4-hydroxycoumarin can be decreased when used in combination with Soybean oil.
Abciximab
Minor
The therapeutic efficacy of Abciximab can be decreased when used in combination with Soybean oil.
Acenocoumarol
Minor
The therapeutic efficacy of Acenocoumarol can be decreased when used in combination with Soybean oil.
Intralipid 20% Toxicity & Overdose Risk
Taking lipid emulsions may lead to side effects such as nausea, vomiting, and muscle spasms. It can also cause allergic reactions or increase the risk of infection if they are administered through a catheter. Rarely, it may lead to a condition called fat overload syndrome, where the body is unable to metabolize the fats quickly. It can also cause problems with blood cells, liver function, and the nervous system. Premature and small babies may have trouble clearing the fats, which can accumulate in their lungs. It is advised not to take more than 0.75 mL/kg/hour.
Intralipid 20% Novel Uses: Which Conditions Have a Clinical Trial Featuring Intralipid 20%?
Two clinical trials are currently being conducted to assess the potential of Intralipid 20% to address Ascorbic Acid Deficiency, Total Parenteral Nutrition and Parenteral Nutrition Requirements.
Condition
Clinical Trials
Trial Phases
Ascorbic Acid Deficiency
1 Actively Recruiting
Parenteral Nutrition
0 Actively Recruiting
Nutritional supplementation
0 Actively Recruiting
Parenteral Nutrition, Total
0 Actively Recruiting
Intralipid 20% Reviews: What are patients saying about Intralipid 20%?
2.3
Patient Review
10/4/2014
Intralipid 20% for A Lack of Fatty Acids
Patient Q&A Section about intralipid 20%
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How do Intralipids make you feel?
"During Interlipid infusion, women may experience shortness of breath, nausea, vomiting, headache, hot flushes, increased temperature/sweating, drowsiness, chest and back pain, slight pressure over the eyes, dizziness, or irritation at the infusion site."
Answered by AI
What is Intralipid 20% used for?
"INTRALIPID 20% is indicated as a source of calories and essential fatty acids for patients requiring parenteral nutrition for extended periods of time, usually more than 5 days. INTRALIPID 20% is also indicated as a source of essential fatty acids for prevention of essential fatty acid deficiency (EFAD)."
Answered by AI
What is Intralipid?
"A woman's NK cells may attack the developing fetus if they perceive it as foreign.
Intralipid is a soybean oil-based fat emulsion solution that contains egg yolk phospholipids and glycerin. Studies in both animals and humans have shown that Intralipid may improve implantation and help sustain pregnancy. Natural Killer (NK) cells are part of the immune system. A woman's NK cells may attack the developing fetus if they see it as a foreign object."
Answered by AI
What is the use of Intralipid?
"This product is used to provide calories to patients receiving intravenous nutrition. Calories are needed to provide the body with energy so it can function properly."
Answered by AI