Rosiglitazone Maleate

Physical Activity, Type 2 Diabetes, Diet
Treatment
20 Active Studies for Rosiglitazone Maleate

What is Rosiglitazone Maleate

RosiglitazoneThe Generic name of this drug
Treatment SummaryRosiglitazone is a diabetes medication that belongs to the thiazolidinedione family. It is sold under the brand names Avandia, Avandamet, or Avandaryl and is used to treat type 2 diabetes. The drug works by activating a receptor in the body called peroxisome proliferator-activated receptor gamma (PPARγ). Rosiglitazone has anti-inflammatory properties, decreasing levels of nuclear factor kappa-B (NFκB) and increasing levels of inhibitor (IκB). Recent research suggests that it may also be beneficial for some patients with Alzheimer's disease who do
Avandiais the brand name
image of different drug pills on a surface
Rosiglitazone Maleate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avandia
Rosiglitazone
1999
51

Effectiveness

How Rosiglitazone Maleate Affects PatientsWhen taken alone, rosiglitazone can raise the amount of cholesterol in the body, including the bad cholesterol (LDL) and the good cholesterol (HDL). Free fatty acids also drop. The bad cholesterol levels will rise within the first two months of taking it and stay high, while the good cholesterol will keep increasing over time. This means that the bad to good cholesterol ratio will be highest after two months and then begin to go down.
How Rosiglitazone Maleate works in the bodyRosiglitazone helps your cells respond more effectively to insulin. It does this by stimulating certain proteins in your cells, called peroxisome proliferator activated receptors, which help regulate how your body processes sugar. This increases the sensitivity of your tissues to insulin, allowing them to better control glucose production, transport, and use.

When to interrupt dosage

The suggested dosage of Rosiglitazone Maleate is reliant upon the diagnosed state, for example Diet, Physical Activity and Type 2 Diabetes. The quantity of dosage is contingent upon the method of administration (e.g. Tablet - Oral or Oral) featured in the table beneath.
Condition
Dosage
Administration
Type 2 Diabetes
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Diet
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral
Physical Activity
, 2.0 mg, 8.0 mg, 4.0 mg, 1.0 mg
, Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, Tablet - Oral

Warnings

Rosiglitazone Maleate Contraindications
Condition
Risk Level
Notes
Hypesthesia
Do Not Combine
Hypesthesia
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Rosiglitazone may interact with Pulse Frequency
There are 20 known major drug interactions with Rosiglitazone Maleate.
Common Rosiglitazone Maleate Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Rosiglitazone.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Rosiglitazone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Rosiglitazone.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Rosiglitazone.
Erlotinib
Major
The metabolism of Erlotinib can be decreased when combined with Rosiglitazone.
Rosiglitazone Maleate Toxicity & Overdose RiskSide effects of taking this drug include retaining extra fluids, increased risk of CHF, and liver damage.
image of a doctor in a lab doing drug, clinical research

Rosiglitazone Maleate Novel Uses: Which Conditions Have a Clinical Trial Featuring Rosiglitazone Maleate?

196 active clinical trials are currently underway to assess the potential of Rosiglitazone Maleate in ameliorating the symptoms of Type 2 Diabetes through Physical Activity and Diet modification.
Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
166 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable, Phase 1
Physical Activity
24 Actively Recruiting
Not Applicable, Phase 1, Phase 2

Rosiglitazone Maleate Reviews: What are patients saying about Rosiglitazone Maleate?

5Patient Review
3/28/2008
Rosiglitazone Maleate for Type 2 Diabetes Mellitus
I made the mistake of taking a whole tab instead of just a half, and as a result I ran out much more quickly than anticipated. My glucose levels were all over the place in that time period (not disastrously so, but still not good). Once I got more pills from the VA though, everything normalized pretty quickly.
5Patient Review
3/31/2021
Rosiglitazone Maleate for Type 2 Diabetes Mellitus
This medication is really effective at lowering insulin resistance.
5Patient Review
5/24/2011
Rosiglitazone Maleate for Treatment-Refractory Type 2 Diabetes Mellitus
I would like to know more about the chemical structure of rosiglitazone.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about rosiglitazone maleate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What drug class is rosiglitazone in?

"Rosiglitazone is a type of medication known as a thiazolidinedione. It helps to control blood sugar levels by increasing the body's sensitivity to insulin, a natural substance."

Answered by AI

Why was rosiglitazone removed from the market?

"Meta-analyses done in the past of both trials and observational studies suggested that there was an increased risk of heart attack and other adverse cardiovascular events when taking rosiglitazone. Therefore, the FDA required a REMS in order to restrict the use of the drug."

Answered by AI

What is rosiglitazone maleate used for?

"The prescription drug Avandia is used to help treat the symptoms of Type 2 diabetes Mellitus. It can be used by itself or with other medications. Avandia is part of a class of drugs referred to as Antidiabetics, Thiazolidinediones."

Answered by AI

Is rosiglitazone still on the market?

"Although rosiglitazone is no longer available in most countries, it can still be bought in the US. Use of the drug has decreased rapidly since warnings were issued in 2007."

Answered by AI

Clinical Trials for Rosiglitazone Maleate

Image of University of California, Los Angeles in Los Angeles, United States.

Tailored DPP for Prediabetes

17 - 25
All Sexes
Los Angeles, CA
The goal of this study is to enhance reach and uptake of diabetes prevention among young adults, with a focus on recruiting underserved and high-need students who face additional challenges, including food and financial insecurity. The specific aims are: Aim 1 - Evaluate the efficacy of an AYA-tailored version of the UC DPP for mitigating type 2 diabetes risk (i.e., weight change) in a pre/post pilot trial. The investigators hypothesize that the AYA-tailored intervention will be effective at producing 5% weight loss from baseline to program completion (at 9-months). Aim 2 - Assess the feasibility and acceptability of an AYA-tailored version of the UC DPP program. The investigators hypothesize that it will be feasible to recruit the desired number of participants given proposed innovative outreach strategies, and that the AYA-tailored intervention will be deemed acceptable to participants both qualitatively and in regards to their retention in the program at rates similar to the larger UC DPP. The investigators will recruit 80 UCLA undergraduate students. Participants will be asked to complete a brief screening online form to assess eligibility and to collect contact information. The PI and/or Research Assistants (RAs) will reach out to eligible participants to obtain informed consent and enroll them in the pilot trial. The investigators will randomize participants to the tailored DPP cohort vs control cohort. Control participants will be offered the opportunity to participate in the tailored DPP in the following academic year. The tailored DPP intervention will be online and asynchronously. Participants will be asked to complete the intervention lessons on their own time. Each lesson typically takes on average 15 minutes to complete. Control group will receive each intervention materials via e-mail for participants to review on their own time and will receive acceptability surveys. The interventions for the control group will be remote. A research assistant will meet with control participants via Zoom to explain the intervention materials. Control group will receive access to a study habits intervention, alcohol use intervention, and financial literacy intervention. At the end of each quarter (Fall, Winter, and Spring), both control and intervention participants will receive an email with a unique link to a brief REDCap survey to ascertain acceptability of sessions/lessons. Furthermore, participants will complete baseline and 9-month follow-up assessments. Participants will complete a 30 minute questionnaire and height/weight measurements will be collected by a RA. Participants will be asked to self-report weight and physical activity at the end of the fall and winter quarter; data will be collected via brief REDCap survey.
Recruiting
Has No Placebo
University of California, Los AngelesLauren E Wisk, PhD
Image of Medpace Clinical Pharmaology Unit in Cincinnati, United States.

PATAS for Type 2 Diabetes

18 - 55
All Sexes
Cincinnati, OH
The primary objective of Part 1 of this study is to evaluate safety and tolerability of single subcutaneous (SC) doses of PATAS in healthy subjects. The secondary objective of Part 1 of this study is to determine the pharmacokinetics (PK) of single SC doses of PATAS in healthy subjects. The primary objectives of Part 2 of this study are to evaluate the safety and tolerability of 4 weekly SC doses of PATAS in subjects with T2D; and to determine the PK and pharmacodynamics (PD) of 4 weekly SC doses of PATAS in subjects with T2D. The secondary objectives of Part 2 of this study are to evaluate the potential effect of multiple SC doses of PATAS on markers of glycemic control, as measured by glucose levels, insulin levels, and other metabolomic biomarkers; and to characterize the adverse event (AE) profiles of the various dose levels of PATAS.
Phase 1
Waitlist Available
Medpace Clinical Pharmaology UnitVincent Marion, Ph.D.AdipoPharma LLC
Have you considered Rosiglitazone Maleate clinical trials? We made a collection of clinical trials featuring Rosiglitazone Maleate, we think they might fit your search criteria.Go to Trials
Image of University of British Columbia - Okanagan in Kelowna, Canada.

Estrogen and Testosterone for Gender Differences in Physiology

18 - 40
All Sexes
Kelowna, Canada
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute. As a result, many diagnoses and treatments are based on male physiology and may not be appropriate or effective for females. Females consistently experience greater risk and report worse neurological outcomes in many diseases, including stroke, cardiac arrest, and dementia. As research in females progresses, differences between sexes and changes throughout the lifespan (e.g., puberty, menopause) highlight the importance of understanding the effects of sex and sex-specific hormones on the body. The brain is arguably the most important organ in the body, consuming 20% of the body's total energy. Previous research supports higher blood flow to the brain in females, and research in animals suggests hormones such as estrogen, progesterone, and testosterone are responsible. However, it is extremely difficult to isolate these hormones in humans, due to natural fluctuations (i.e., menstrual cycle). Therefore, the investigators plan to explore the direct role of these sex-specific hormones in regulating blood flow to the brain by blocking hormone production in healthy males and females and giving back testosterone and estrogen, respectively. The investigators will then conduct a range of tests to look at blood flow to the brain at rest and during various stressors. This research will provide crucial insight into how males and females differ in regulation of brain blood flow and inform new treatments and therapies to a wide range of brain injuries and diseases, improving outcomes and reducing the sex disparity in clinical pathways.
Waitlist Available
Has No Placebo
University of British Columbia - OkanaganPhilip Ainslie, PhD
Have you considered Rosiglitazone Maleate clinical trials? We made a collection of clinical trials featuring Rosiglitazone Maleate, we think they might fit your search criteria.Go to Trials
Image of Exercise Metabolism and Inflammation Laboratory in Okanagan, Canada.

Aerobic Exercise with Blood Flow Restriction for Type 2 Diabetes

19 - 64
All Sexes
Okanagan, Canada
The goal of this trial is to learn if blood flow restriction training with treadmill walking is possible for individuals living with type 2 diabetes. It will also learn about how the blood flow restriction with treadmill walking could improve health. The main questions it aims to answer are: Is 6 weeks of treadmill walking with blood flow restriction reasonable for people with type 2 diabetes to perform? Does treadmill walking with blood flow restriction training help manage type 2 diabetes better than just treadmill walking? Researchers will compare treadmill walking with blood flow restriction to treadmill walking without blood flow restriction to see if blood flow restriction works to manage type 2 diabetes based on fitness and blood sugar levels. Participants will: Perform treadmill walking with or without blood flow restriction for 96 minutes a week for 6 weeks. Visit the lab before and after the exercise for tests and questionnaires.
Waitlist Available
Has No Placebo
Exercise Metabolism and Inflammation Laboratory (+2 Sites)Martin Senechal, PhD
Image of Jefferson Health New Jersey in Sewell, United States.

Continuous vs Finger-stick Glucose Monitoring for Type 2 Diabetes in Pregnancy

18+
Female
Sewell, NJ
The purpose of this study is to compare patient adherence to blood sugar monitoring during pregnancy using two different measurement methods in pregnancies complicated by pregestational type 2 diabetes (T2DM). Pregnant patients with T2DM are at risk of having larger babies, babies with low sugar levels in the first 24 hours of life, higher rates of cesarean delivery, stillbirth (death of baby inside the womb), and hypertensive or high blood pressure disorders of pregnancy, such as preeclampsia. Prior studies have shown that treating high blood sugars in pregnancy with medications can reduce these risks. To determine the amount of medication needed, recording of blood sugar levels is necessary. This trial aims to determine whether continuous blood sugar monitors have improved patient recording of blood sugar levels over finger stick blood sugar measurements. Patients involved in the study will be assigned to either: 1. Fingerstick glucose monitoring (FSG) 2. Continuous glucose monitoring (CGM) Patients will be randomize in a 1:1 ratio. FSG Group: blood sugar is tested four times daily - once fasting and two hours after every meal (post-prandial). Blood will be tested using a glucometer, and values will be recorded in a blood sugar log from the time of enrollment to the time of delivery. CGM Group: A CGM sensor will be placed on the patient's arm for blood sugar collection every 3-5 minutes. This data is sent to a phone application from the time of enrollment to the time of delivery. These sensors will need to be replaced every 14 days. Percent adherence will be recorded from the time you were randomized to a study group until delivery.
Recruiting
Has No Placebo
Jefferson Health New Jersey (+1 Sites)
Image of McMaster University in Hamilton, Canada.

Health Coaching for Type 2 Diabetes and Mental Health

18+
All Sexes
Hamilton, Canada
Managing both type 2 diabetes and mental health challenges can be difficult, and many people do not receive care that supports both. This study looks at how virtual health coaching and support from interdisciplinary care teams can help people better manage their health. The purpose of this study is to test the effectiveness of a virtual health coaching program for adults living with type 2 diabetes and mental health challenges compared to usual care. The Technology-Enabled Collaborative Care for type 2 Diabetes and Mental health (TECC-DM) program includes weekly coaching calls, support from an interdisciplinary care team, and online tools to aid self-management. The findings from this study will be used to help improve services for people who have type 2 diabetes and co-occurring mental health symptoms.
Waitlist Available
Has No Placebo
McMaster UniversityCarly Whitmore, RN PhD
Have you considered Rosiglitazone Maleate clinical trials? We made a collection of clinical trials featuring Rosiglitazone Maleate, we think they might fit your search criteria.Go to Trials
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security