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What is Sulfadiazine Sodium
SulfadiazineThe Generic name of this drug
Treatment SummarySulfadiazine is a medication used in combination with pyrimethamine to treat toxoplasmosis in people with HIV/AIDS, and in newborns with infections they were born with.
Sulfadiazineis the brand name
Sulfadiazine Sodium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sulfadiazine
Sulfadiazine
1994
3
Approved as Treatment by the FDA
Sulfadiazine, otherwise called Sulfadiazine, is approved by the FDA for 4 uses which include Toxoplasmosis and Acquired Immunodeficiency Syndrome .Toxoplasmosis
Acquired Immunodeficiency Syndrome
Acute Otitis Media caused by Haemophilus Influenzae
Encephalitis
Effectiveness
How Sulfadiazine Sodium Affects PatientsSulfadiazine is an antibiotic used to treat bacterial infections. It works by stopping the bacteria from multiplying. It is a type of sulfonamide which is easily taken orally but not usually injected into the body. Sulfadiazine spreads throughout all the tissues in the body, and is found in high levels in fluids like pleural, peritoneal, synovial, and ocular fluids. It is no longer used to treat meningitis, but it can still be detected in the fluid surrounding the brain if there is an infection. The effectiveness of this drug is reduced if there is pus present.
How Sulfadiazine Sodium works in the bodySulfadiazine works by blocking the action of a bacterial enzyme called dihydropteroate synthetase. This enzyme is needed for a certain type of bacteria to make folic acid, which is essential for its survival. By stopping this enzyme from working, sulfadiazine stops the bacteria from making folic acid and kills it.
When to interrupt dosage
The proposed dosage of Sulfadiazine Sodium is subject to the diagnosed condition, such as Acute Otitis Media triggered by Haemophilus Influenzae, Conjunctivitis, Inclusion and Nocardiosis. The measure of dosage is contingent upon the method of application (e.g. Cream - Vaginal or Tablet) specified in the table underneath.Condition
Dosage
Administration
Meningitis caused by Haemophilus influenzae
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Haemophilus influenzae
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
recurrent prophylaxis of Rheumatic fever
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Malaria
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Chancroid
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Conjunctivitis, Inclusion
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Alopecia
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Toxoplasmosis
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Encephalitis
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Wound Infection
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Nocardiosis
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
prophylaxis of Meningococcal meningitis
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Acquired Immunodeficiency Syndrome
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Urinary Tract Infections
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Trachoma
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Rheumatic Fever
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Second Degree Burns
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Meningitis, Meningococcal
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Acute Otitis Media caused by Haemophilus Influenzae
, 500.0 mg, 410.0 mg, 500.5 mg, 167.0 mg, 400.0 mg, 8.0 %, 41.0 mg/mL, 167.0 mg/mL
, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Vaginal, Suppository - Vaginal, Suppository, Cream, Cream - Vaginal
Warnings
Sulfadiazine Sodium ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Sulfadiazine Sodium Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Sulfadiazine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Sulfadiazine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Sulfadiazine.
Cabozantinib
Major
The metabolism of Cabozantinib can be decreased when combined with Sulfadiazine.
Capecitabine
Major
The metabolism of Capecitabine can be decreased when combined with Sulfadiazine.
Sulfadiazine Sodium Toxicity & Overdose RiskThe lowest toxic dose of the drug in mice has been found to be 1500mg/kg.
Sulfadiazine Sodium Novel Uses: Which Conditions Have a Clinical Trial Featuring Sulfadiazine Sodium?
28 active clinical trials are currently investigating the potential of Sulfadiazine Sodium to alleviate Second Degree Burns, Trachoma and Toxoplasmosis.Condition
Clinical Trials
Trial Phases
Rheumatic Fever
0 Actively Recruiting
prophylaxis of Meningococcal meningitis
0 Actively Recruiting
Encephalitis
1 Actively Recruiting
Phase 2
Meningitis caused by Haemophilus influenzae
0 Actively Recruiting
Urinary Tract Infections
4 Actively Recruiting
Not Applicable
Wound Infection
0 Actively Recruiting
Second Degree Burns
3 Actively Recruiting
Phase 2, Phase 3
Trachoma
1 Actively Recruiting
Phase 4
Toxoplasmosis
1 Actively Recruiting
Phase 4
Acquired Immunodeficiency Syndrome
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Alopecia
0 Actively Recruiting
Conjunctivitis, Inclusion
0 Actively Recruiting
Nocardiosis
0 Actively Recruiting
Meningitis, Meningococcal
0 Actively Recruiting
Acute Otitis Media caused by Haemophilus Influenzae
0 Actively Recruiting
Chancroid
0 Actively Recruiting
Haemophilus influenzae
0 Actively Recruiting
Malaria
0 Actively Recruiting
recurrent prophylaxis of Rheumatic fever
0 Actively Recruiting
Patient Q&A Section about sulfadiazine sodium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is sulfadiazine used for?
"Sulfadiazine is used to treat or prevent infections by inhibiting the growth of bacteria. It is part of the group of medicines known as sulfonamide antibiotics. Sulfadiazine will not work for colds, flu, or other virus infections."
Answered by AI
What are side effects of sulfadiazine?
"Patients with second or third-degree burns may experience any or all of the following symptoms: back, leg, or stomach pains; blistering, peeling, or loosening of the skin; blue-green to black skin discoloration; fever with or without chills; general body swelling; increased sensitivity of the skin to sunlight, especially in patients with burns on large areas; intense itching of burn wounds."
Answered by AI
Is sulfadiazine an antibacterial?
"This medication is used to treat bacterial infections. It works by Eliminating the bacteria that cause the infection."
Answered by AI
What is sulfadiazine sodium?
"It will not work for viral infections (such as common cold, flu).
This medication is used to treat and prevent infections. Sulfadiazine belongs to a class of drugs known as sulfa antibiotics. These antibiotics work by stopping the growth of bacteria and other organisms. However, they can only treat certain types of infections and will not work for viral infections, such as the common cold or flu."
Answered by AI