THC for Cannabis Use

Phase < 1

Recruiting

Led By Natania A Crane, PhD

Research Sponsored by University of Illinois at Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Must not be taking psychoactive medications that would interfere with dronabinol and/or interpretation of fMRI data, including but not limited to the following classes of psychotropics: antidepressants, anxiolytics, sedative hypnotics, stimulants, antipsychotics, mood stabilizer

negative urine drug screen (UDS) for all substances except THC (THC allowed)

Must not have

Positive UDS for any drug except THC

Timeline

Screening 3 weeks

Treatment Varies

Follow Up first and second laboratory visit, at baseline (time 0) and at peak drug response (90-120 minutes) after drug administration. outcome measure is change in peak score during placebo (peak minus baseline) compared to change in peak score during thc

Awards & highlights

All Individual Drugs Already Approved

Summary

This trial will study how THC affects the brain's reward system.

Who is the study for?

This trial is for healthy, English-speaking adults with a BMI of 19-26 who've used cannabis over 10 times but not daily. They must have no severe drug use disorders or need for psychoactive meds, and be free from medical conditions that affect MRI results or are worsened by THC.

What is being tested?

The study examines how THC affects mood and brain responses in non-daily cannabis users compared to a placebo. Participants will undergo fMRI scans to track brain activity changes related to the rewarding effects of THC.

What are the potential side effects?

THC can cause altered mental states, anxiety, changes in mood, sensory perception alterations, increased heart rate, dry mouth, red eyes, coordination issues and memory impairment.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am not taking any medications that affect mood or the way my brain works.

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My drug test was negative, except for THC.

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My drug test was negative, except for THC.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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My drug screen was positive for substances other than marijuana.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ first and second laboratory visit, at baseline (time 0) and at peak drug response (90-120 minutes) after drug administration. outcome measure is change in peak score during placebo (peak minus baseline) compared to change in peak score during thc

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~first and second laboratory visit, at baseline (time 0) and at peak drug response (90-120 minutes) after drug administration. outcome measure is change in peak score during placebo (peak minus baseline) compared to change in peak score during thc

This trial's timeline: 3 weeks for screening, Varies for treatment, and first and second laboratory visit, at baseline (time 0) and at peak drug response (90-120 minutes) after drug administration. outcome measure is change in peak score during placebo (peak minus baseline) compared to change in peak score during thc for reporting.