← Back to Search

Proton Pump Inhibitor

High Dose Omeprazole for Pancreatic Cancer (OU202005AJ Trial)

Phase < 1

Recruiting

Led By Ajay Jain, MD

Research Sponsored by University of Oklahoma

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Newly diagnosed exocrine pancreatic cancer with pathology confirmed as adenocarcinoma

Patient is a candidate for surgical resection of pancreatic cancer

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 years

Awards & highlights

OU202005AJ Trial Summary

This trial is testing if a high dose of a common stomach acid drug is safe for people with a certain kind of cancer.

Who is the study for?

This trial is for adults diagnosed with a specific type of pancreatic cancer known as exocrine adenocarcinoma, who are fit enough for surgery. They must not be pregnant or breastfeeding and should have no major heart issues or conditions that affect medication absorption. A negative pregnancy test is required for women able to bear children.Check my eligibility

What is being tested?

The study aims to evaluate the safety and effects of high doses of Omeprazole in patients with exocrine pancreatic cancer. It will involve participants who may or may not have received chemotherapy before joining the trial.See study design

What are the potential side effects?

While the side effects aren't specified here, high doses of Omeprazole could potentially cause digestive disturbances, headaches, dizziness, skin reactions, and an increased risk for bone fractures or kidney problems.

OU202005AJ Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been newly diagnosed with a specific type of pancreatic cancer.

Select...

I am eligible for surgery to remove pancreatic cancer.

Select...

I can take care of myself and am up and about more than half of the day.

Select...

I am not pregnant and either cannot become pregnant or have had a negative pregnancy test recently.

Select...

I am 18 years old or older.

OU202005AJ Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Proportion

Safety and Tolerability

Secondary outcome measures

Correlation

v-ATPase LC3-I and LC3-II expression

OU202005AJ Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Arm A (High Dose)Experimental Treatment1 Intervention

Omeprazole, 80 mg, PO, BID for 2 weeks prior to surgical therapy of pancreatectomy. All 30 subjects in Arm A to be enrolled prior to Arm B cohort enrollment.

Group II: Arm B (Normal Dose)Placebo Group1 Intervention

Omeprazole, 20 mg, PO, QD for 2 weeks prior to surgical therapy of pancreatectomy.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Omeprazole

2006

Completed Phase 4

~940

0 / 5Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of OklahomaLead Sponsor

455 Previous Clinical Trials

95,596 Total Patients Enrolled

Ajay Jain, MDPrincipal InvestigatorUniversity of Oklahoma

2 Previous Clinical Trials

170 Total Patients Enrolled

Media Library

Omeprazole (Proton Pump Inhibitor) Clinical Trial Eligibility Overview. Trial Name: NCT04930991 — Phase < 1

Pancreatic Cancer Research Study Groups: Arm A (High Dose), Arm B (Normal Dose)

Pancreatic Cancer Clinical Trial 2023: Omeprazole Highlights & Side Effects. Trial Name: NCT04930991 — Phase < 1

Omeprazole (Proton Pump Inhibitor) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04930991 — Phase < 1

~16 spots leftby Jun 2025

Unbiased ResultsWe believe in providing patients with all the options.

Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.

Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.