Nerve Block + Dexamethasone for Migraine

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase < 1

Recruiting

Sponsor: Texas Tech University Health Sciences Center, El Paso

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Trial Summary

What is the purpose of this trial?

For some patients who come to the emergency department for treatment of a migraine headache, peripheral headache nerve blocks (PHNB) have proven to be an efficient and effective treatment for headache relief. Previous studies have demonstrated that adding steroids as an adjunct treatment to standard migraine treatment can reduce recurrence of headaches in the subsequent few days.

Research Team

Susan Watts, PhD.

Principal Investigator

Texas Tech University Health Sciences Center, Department of Emergency Medicine

Eligibility Criteria

This trial is for individuals who meet the criteria for migraine headaches and have experienced significant relief after a nerve block treatment. They must not have head trauma, suspicion of secondary headache causes like stroke or tumors, be chronically on steroids, have allergies to dexamethasone, uncontrolled diabetes, or compromised immune systems.

Inclusion Criteria

I have had a nerve block with a specific medication.

My headache pain decreased significantly after a nerve block.

I have been diagnosed with migraines according to ICHD-3 standards.

Exclusion Criteria

You are allergic to dexamethasone.

Known to be immunocompromised

I have headaches with symptoms of a viral infection.

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Treatment Details

Interventions

Dexamethasone (Corticosteroid)
Placebo (Other)

Trial OverviewThe study tests if adding oral dexamethasone to a peripheral headache nerve block can prevent the recurrence of migraines within 72 hours post-treatment. Participants will either receive dexamethasone or a placebo alongside their usual migraine management.

Participant Groups

2Treatment groups

Experimental Treatment

Placebo Group

Group I: DexamethasoneExperimental Treatment1 Intervention

single oral dose of dexamethasone (8mg)

Group II: PlaceboPlacebo Group1 Intervention

Single oral dose of placebo pill