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Vasodilator

Nitroglycerin Topical Product for Circulatory Shock

N/A
Waitlist Available
Led By John C. Greenwood, MD
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up cvp was recorded for the control group, then for the ntg group at postoperative baseline, 3-minutes, and 30-minutes after topical ntg application
Awards & highlights
No Placebo-Only Group

Summary

This is an open-label, single center, trial that will enroll up to 25 participants with circulatory shock after cardiac surgery. Participants will be administered a topical sublingual nitroglycerin solution and assessed for changes microcirculatory blood flow using incident dark field microscopy.

Eligible Conditions
  • Circulatory Shock
  • Cardiac Shock

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~map was recorded for the control group, then for the ntg group at postoperative baseline, 3-minutes and 30-minutes after topical ntg application.
This trial's timeline: 3 weeks for screening, Varies for treatment, and map was recorded for the control group, then for the ntg group at postoperative baseline, 3-minutes and 30-minutes after topical ntg application. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Perfused Vessel Density (PVD)
Secondary study objectives
Cardiac Index
Central Venous Pressure
Mean Arterial Pressure

Side effects data

From 2019 Phase 4 trial • 66 Patients • NCT02209636
38%
Non-serious adverse events
3%
Hospitalization
100%
80%
60%
40%
20%
0%
Study treatment Arm
Lanthanum Carbonate
Placebo
Placebo- Phosphorus Balance Sub-study
Lanthanum Carbonate- Phosphorus Balance Sub-study

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Topical nitroglycerinExperimental Treatment1 Intervention
A topical nitroglycerin solution will be applied to the area of interest
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nitroglycerin Topical Product
2021
N/A
~50

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Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
2,069 Previous Clinical Trials
42,713,428 Total Patients Enrolled
John C. Greenwood, MDPrincipal InvestigatorUniversity of Pennsylvania
~11 spots leftby Oct 2025
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