Prevention Clinical Trials
Here are the 6 most popular medical studies for prevention
Vitamin
Vitamin D + Fish Oil for Health Improvement
This trial is studying whether taking daily dietary supplements of vitamin D3 or omega-3 fatty acids reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses.
Behavioral Intervention
Improved Perioperative Preventive Measures for Surgical Site Infections
This trial is testing a multifaceted program to see if it can reduce surgical site infections (SSIs). The program includes improved basic perioperative preventive measures. The investigators aim to examine the relative effectiveness of each component of this program in controlling ESKAPE transmission and reducing SSIs and to identify an optimal implementation strategy for national dissemination.
Behavioural Intervention
Fall Prevention Program for Older Adults
This trial is studying a new way to prevent falls in older adults that includes an evaluation by a physical therapist and pharmacist in addition to the usual care by an ED clinician. The study will last for 12 months and measure recurrent falls.
Behavioral Intervention
Fuerte Program for Psychological Trauma in Immigrant Youth
This trial will test the efficacy of a school-based group prevention program called Fuerte, which is designed to help newcomer Latinx immigrant youth who are at risk of experiencing traumatic stress. The program will be implemented by mental health providers from various county community-based organizations, as well as from the SFUSD Wellness Centers.
Behavioral Intervention
Behavioral Activation for Alcohol Use Disorder
This trial will test a new way to help college freshmen who drink too much alcohol. The intervention will address concerns that are most relevant to these students and be integrated into the college curriculum.
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Prediabetes Clinical Trials
View 7 Prediabetes medical studies.
Biguanides
Lifestyle Changes + Metformin for Diabetes Prevention
This trial looks at the ability of an intensive lifestyle or metformin to prevent or delay the development of diabetes in a high risk population. Lifestyle reduced diabetes onset by 58% and metformin reduced diabetes onset by 31%.
Behavioral Intervention
Diabetes Genetic Counseling for Obesity
This study will examine the impact diabetes genetic counseling on patient motivation and disease prevention behaviors among subjects with pre-diabetes. Intervention subjects will be provided with their individual diabetes genotype risk score derived from aggregating the combined results of 37 diabetes risk-associated genetic loci. Controls will not be tested. All subjects will be enrolled in a 12-week diabetes prevention program.
Behavioral Intervention
Chronic care management 1-6 for High Blood Pressure
CONTEXTE: L'Agence de la santé et des services sociaux de Montréal (ASSS) invited our research team to evaluate the implementation of an integrated and interdisciplinary primary care network for prevention and management of cardiometabolic risks (diabetes and hypertension) (PCR). The intervention is based on the Chronic Care Model and the development of an integrated services network. PCR is to be implemented in 6 territories of "Centre de santé et de services sociaux (CSSS)". A first application for funding was made to Fonds Pfizer-FRSQ-MSSS for an evaluation that has to be completed in the first 24 month after the beginning of the implementation. This application to the PHSI program at CIHR is complementary and will ensure an evaluation of the sustainability of PCR and of long term effects (40 months after the beginning of the implementation) for patients and for their primary care physicians. In each CSSS, PCR plans for : 1- an interdisciplinary team in an education center working with primary care physicians and offering to referred patients a pre-determined sequence of clinical interventions over a 2-year-period; 2- a program supporting primary care physicians (continuing education, documentation and clinical guidelines, referral system to second line of care); 3- networking between actors of "Réseau local de services (RLS)" insuring clinical information transfer required for efficient patient management. OBJECTIVES: 1-evaluate PCR effects according to territory, time and degree of exposure (specifically benefits to registered patients and support to participating primary care physicians); 2- identify the degree of implementation of PCR in each CSSS territory and the related contextual factors; 3- examine the relationship between the effects identified, the degree of implementation of PCR and the related contextual factors; 4- assess the impact of implementing PCR on the strengthening of RLS. METHODS: The proposed evaluation will be done through a mixed design including two complementary strategies. Using a "quasi-experiment/before-after" design, the first strategy is a quantitative approach looking at the program effects and their variation between territories. This analysis will use data from the PCR clinical database (ex.: HbA1c, BP, lifestyle) and from patient questionnaire inquiring about care experience, utilization of services, chronic care follow-up, self-management and quality of life. Around 3000 patients will be enlisted. A primary care physician questionnaire will enquire about PCR effects on their practice. Using primarily a qualitative and a case study approach, each of the 6 territories being one case, the second strategy will identify the degree of implementation of PCR and the explanatory contextual factors. This analysis with use data obtained from semi-structured interviews with program managers. The results of this analysis will be summarized in a monograph for each territory. According to the type of indicator analyzed, objective 3 will be fulfilled using linear models or longitudinal multilevel models supplemented with an interpretive approach using the information from monographs and discussion groups. The impact of implementing PCR on RLS will be assessed through interviews with key informants. RESULTS AND EXPECTED IMPACT: Our study will identify the effectiveness of PCR and contextual factors associated with successful implementation and sustainability of PCR. Detailed contextual information will allow application of our results to other environments that have similar context and to other chronic conditions that could benefit from an integrated services network. KNOWLEDGE TRANSFER: Since decision makers, clinicians and researchers did and will take part in all phases of PRC evaluation (planning, data collection, analysis and interpretation), diffusion of information regarding the program is an integral part of the research process. In addition, results will be presented at local, regional, provincial and national conferences and published in reports and articles widely distributed. More specifically, a regional symposium will be organized to share evaluation results with all CSSS in the region (n=12) and with all our local and regional partners.
Obesity Clinical Trials
View 6 Obesity medical studies.
Behavioral Intervention
Dissonance-Based Obesity Prevention + Response and Attention Training for Obesity
This trial is testing whether a novel obesity prevention program is more effective when done in single-sex versus mixed-sex groups, and whether adding food response and attention training increases weight gain prevention effects.
Behavioral Intervention
Diabetes Genetic Counseling for Obesity
This study will examine the impact diabetes genetic counseling on patient motivation and disease prevention behaviors among subjects with pre-diabetes. Intervention subjects will be provided with their individual diabetes genotype risk score derived from aggregating the combined results of 37 diabetes risk-associated genetic loci. Controls will not be tested. All subjects will be enrolled in a 12-week diabetes prevention program.
Behavioural Intervention
PEER group intervention for Obesity
Project PEER utilizes a randomized controlled study design to investigate the combined effects of an exercise and nutrition intervention that is based on self-efficacy principles and delivered primarily by peer educators to reduce the risk for obesity in female college freshman over one academic year (N = 300). The control group will receive minimal interaction from the research team, paralleling the typical freshman experience on the UIUC campus. Recruitment will take place in two waves (consecutive fall terms with n = 150). During the final year (Fall 2010) of the project, a General Education course will be offered that targets weight management. Importantly, the discussion groups for this course will be taught by peer educators trained using the peer resources further refined during the PEER project. In addition to conventional measures of content knowledge assessed in the college classroom when obtaining class credit, personal physical activity and nutrition behaviors along with behavioral determinants (self-efficacy, self-regulatory skills and outcome expectations) will also be assessed. Primary Aim 1: To determine the effectiveness of a peer-delivered self efficacy-based behavioral intervention to enhance nutrition and physical activity behaviors and subsequently weight management success in female university freshman over one academic year. We hypothesize that freshmen randomized to the intervention group will be more successful in losing or maintaining weight than the control group through a combination of diet and physical activity strategies. Primary Aim 2: To examine the role played by social cognitive factors in changing nutrition and physical activity behaviors across one academic year. We hypothesize that self-efficacy will have both a direct influence on behavior and an indirect effect through its influence on self-regulatory skills and outcome expectations.
Phase 3 Prevention Clinical Trials
View 80 phase 3 prevention medical studies.
Vitamin Supplement
Vitamin D for COVID-19
This trial is testing whether vitamin D supplements can reduce the rate of people seeking healthcare for symptoms related to COVID-19, and whether it can reduce the risk of infection with the virus in people who have been recently diagnosed with COVID-19.
Biguanides
Lifestyle Changes + Metformin for Diabetes Prevention
This trial looks at the ability of an intensive lifestyle or metformin to prevent or delay the development of diabetes in a high risk population. Lifestyle reduced diabetes onset by 58% and metformin reduced diabetes onset by 31%.
Prevention Clinical Trials With No Placebo
View 80 prevention medical studies that do not have a placebo group.
Behavioural Intervention
Risk-Based Screening for Breast Cancer
This trial is comparing annual breast cancer screening to a risk-based breast cancer screening schedule. The goal is to see if the risk-based schedule detects breast cancers earlier and causes fewer false positives.
Behavioral Intervention
Counseling for Suicide
This trial is testing whether an anonymous online screening for stress, depression, substance use, and suicidal thoughts will help medical trainees and faculty who are in distress. It is expected that the screening will make them more likely to come for counseling and that their suicide risk factors will be lower after they receive treatment.
View More Prevention Trials
See another 52 medical studies focused on prevention.
Frequently Asked Questions
Introduction to prevention
What are the top hospitals conducting prevention research?
When it comes to groundbreaking clinical trials in the field of prevention, several top hospitals across the United States are making notable strides. Brigham and Women's Hospital in Boston leads the way with six active prevention trials aimed at identifying strategies to ward off various diseases. While they have yet to conduct any prevention trials historically, their commitment to preventive medicine is evident. Similarly, Mayo Clinic in Rochester is actively engaged in four ongoing prevention studies, focusing on innovative approaches to disease prevention. Although they also do not have a past record of conducting preventive trials, their dedication towards exploring preventative measures is commendable.
In Aurora, Colorado, Children's Hospital Colorado recognizes the importance of early intervention and has three active prevention trials underway. These efforts aim to identify ways to prevent or mitigate health issues from an early age and support children's well-being as they grow up.
Meanwhile, Dent Neurologic Institute located in Amherst acknowledges that preventing neurological disorders carries immense significance for overall health outcomes. They currently contribute by running three active clinical trials focused on preventive strategies within this realm.
Lastly,nestled away in Bellevue,the Northwest Clinical Research Center signifies its role as a crucial player by hosting three ongoing preventive clinical investigations without prior historical input.Their current endeavors involve pioneering research into preventative measures against various conditions related issues emphasizing their contribution towards ensuring healthier lives
These esteemed institutions demonstrate unwavering commitment toward mitigating risks before diseases surface and promoting overall wellness through proactive approaches.Across different locations these top-tier hospitals exemplify how ongoing collaborative work continues driving us closer than ever before towards cultivating healthier lives for everyone
Which are the best cities for prevention clinical trials?
When it comes to prevention clinical trials, several cities have emerged as leaders in research and development. Boston, Massachusetts leads the way with 18 active trials focusing on interventions like Enteric Coated Aspirin, Deferoxamine, and Vitamin d. New york, New York follows closely behind with 13 ongoing studies examining strategies such as targeted screening advice based on comprehensive risk assessments. Miami, Florida; Phoenix, Arizona; and Baltimore Maryland also contribute significantly to prevention research with their own set of active trials exploring various preventive measures. These cities offer individuals opportunities to participate in cutting-edge clinical trials aimed at preventing diseases and improving overall health outcomes.
Which are the top treatments for prevention being explored in clinical trials?
When it comes to prevention, clinical trials are currently investigating the efficacy of several promising treatments. The top contenders in these trials include:
- Daratumumab: Being tested in multiple ongoing trials
- Belantamab mafodotin: Showing potential as a preventive treatment
- Lenalidomide: Under investigation for its preventive properties
These treatments hold promise for preventing breast cancer and may provide a breakthrough in the fight against this disease. Continued research and development are crucial to improving prevention strategies and ultimately reducing the burden of breast cancer worldwide.
What are the most recent clinical trials for prevention?
Exciting advancements are being made in the realm of prevention, as recent clinical trials offer promising approaches to safeguard against various health conditions. Among these studies is a Phase 2 trial investigating the efficacy of high-dose ORC-13661 for prevention. Additionally, a Phase 3 trial called ReMMiD-C Therapeutic Arm A aims to explore preventive strategies further. Another Phase 3 trial named ROSE (Reach Out, Stay Strong, Essentials) focuses on preventing complications in mothers with newborns. Furthermore, a Phase 2 trial examines the potential benefits of smartphones in preventive measures. Lastly, Stellate ganglion block is being explored through both Phase 2 and Phase 3 trials for its preventative properties. With these innovative initiatives underway, we can anticipate significant progress in disease prevention efforts moving forward.
What prevention clinical trials were recently completed?
Recently, several clinical trials focused on prevention have concluded, providing valuable insights into strategies for disease avoidance. These studies demonstrate the commitment of researchers to proactively addressing health concerns.