Trial Summary
What is the purpose of this trial?This trial is testing a new type of PET scan that uses tiny particles to take clearer pictures of brain tumors. The study aims to see how these particles spread and leave the body. This could help improve future treatments for brain tumor patients.
Eligibility Criteria
This trial is for adults over 18 with confirmed malignant brain tumors, pituitary adenomas, or brain metastases from known cancers. Participants must use birth control if of childbearing age and have normal heart function. Pregnant or breastfeeding individuals, those with multiple active cancers, severe claustrophobia, or weight over 400 lbs cannot join.Inclusion Criteria
All patients of childbearing age must use an acceptable form of birth control
I am 18 years old or older.
If you are a woman who has not gone through menopause, you must have a negative pregnancy test.
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Exclusion Criteria
I have cancer that has spread from my brain to other parts of my body.
Known pregnancy or breast-feeding
Medical illness unrelated to the tumor which in the opinion of the attending physician and principal investigator will preclude administration of the tracer
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Participant Groups
The study tests a new PET scan tracer called 89Zr-DFO-cRGDY-PEG-Cy5-C' dots to see how well it can image brain tumors and track its distribution and removal in the body. This is the first time these particles are used in humans after being tested in mice.
2Treatment groups
Experimental Treatment
Group I: surgical patientsExperimental Treatment2 Interventions
Patients will be i.v. injected with approximately 5 mCi (\~3.4-6.7 nanomoles) of 89Zr-DFO-cRGDY-PEG-Cy5-C' dots (specific activity range 750.0 - 1450 mCi/ µmol) and undergo the microdosing study for purposes of collecting particle tracer kinetic and dosimetry data. The patient's PET/CT Brain scans may be acquired prior to surgery. All non-surgical and some surgical patients (at the discretion of the physician) will undergo PET brain imaging.
Group II: non-surgical patientsExperimental Treatment2 Interventions
Before the patient's PET Brain scans patients will be i.v. injected with approximately 5 mCi (\~3.4-6.7 nanomoles) of 89Zr-DFO-cRGDY-PEG-Cy5-C' dots (specific activity range 750.0 - 1450 mCi/ µmol) and undergo the microdosing study for purposes of collecting particle tracer kinetic and dosimetry data. All non-surgical and some surgical patients (at the discretion of the physician) will undergo PET brain imaging
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Memorial Sloan Kettering Cancer CenterNew York, NY
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Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer CenterLead Sponsor