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Inhibitory Control Training for Healthy Aging

N/A

Waitlist Available

Led By Fang Jiang, Ph.D

Research Sponsored by University of Nevada, Reno

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Must not have

History of epilepsy, stroke, Parkinson's disease, Alzheimer's disease, attention deficit-hyperactivity disorder

Early dementia or cognitive impairment

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 30 days after training

Summary

This trial will research how age-related declines in multisensory & postural control relate to changes in GABA-mediated inhibition & network segregation. It will assess & train inhibitory functions with the potential to develop new rehabilitation protocols for older adults.

Who is the study for?

This trial is for older adults aged between 65 and 80, as well as a younger group aged between 20 and 35. Participants must not have serious vision or uncorrected hearing problems, early dementia, cognitive impairments, epilepsy, stroke, Parkinson's disease, Alzheimer's disease, ADHD or history of significant head injury.

What is being tested?

The study investigates if inhibitory control training can improve multisensory temporal processing and postural control in older adults by affecting GABA-mediated inhibition in the brain. It compares this method to knowledge-based training through a multimodal approach.

What are the potential side effects?

Since the interventions involve non-pharmacological cognitive training methods rather than medication or invasive procedures, no direct side effects are expected from participating in this clinical trial.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a history of epilepsy, stroke, Parkinson's, Alzheimer's, or ADHD.

Select...

I have been diagnosed with early dementia or mild cognitive impairment.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 30 days after training

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~30 days after training

This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days after training for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Brain GABA level change

Brain GABA level change maintenance

Multisensory temporal processing performance change

+5 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Inhibitory control trainingExperimental Treatment1 Intervention

In the inhibitory control training condition, participants will be trained with tasks that involve both response withholding and rule switching. For example, participants will sort polygons based on features (e.g., shape or color) and will be asked to either provide or withhold sorting responses when presented with different cues. Rule-switching is introduced when participants must inhibit the "rule" used in the previous trial set and change the focus of their attention to a new sorting and/or inhibitory rule. Task difficulty will progressively increase over the course of training based on participants' abilities.

Group II: knowledge-based trainingPlacebo Group1 Intervention

The knowledge-based training condition serves as the control, in which participants will be presented with questions from different categories such as vocabulary, science, or geography and asked to select the correct answer from 4 alternatives within a certain time limit. Task difficulty will progressively increase over the course of training based on participants' abilities.

0 / 2Eligibility criteria met