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Nerve Block for Reducing Pain After Wisdom Tooth Extraction
Phase 2
Recruiting
Led By Gayathri D Subramanian, PhD, DMD
Research Sponsored by Rutgers, The State University of New Jersey
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, post-procedure (day 1) and at post-operative visit (day 8)
Awards & highlights
No Placebo-Only Group
Summary
This trial is testing whether a nerve block can reduce pain for people getting their lower wisdom teeth removed while sedated. People will be asked about their pain and pain meds use for a week after the procedure, and then checked in on 8 days later.
Who is the study for?
This trial is for adults aged 18-64 who need their lower wisdom teeth removed and can consent to the study. They must be healthy enough for sedation, not pregnant, have internet access with a smartphone, and able to take common pain meds like Tylenol or Advil.
What is being tested?
The study tests if a local anesthetic injection called Temporo-masseteric Nerve Block reduces pain after wisdom tooth removal under sedation. Participants will report their pain levels and medication use over the first week post-surgery.
What are the potential side effects?
Potential side effects may include discomfort at the injection site, possible allergic reactions to the anesthetic used in the nerve block, and typical risks associated with dental procedures such as swelling or infection.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, post-procedure (day 1) and at post-operative visit (day 8)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, post-procedure (day 1) and at post-operative visit (day 8)
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Adverse effects
Masticatory muscle pain to palpation- Temporalis and Masseter
Mean Numerical Pain Rating Scale pain score
+3 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Temporo-masseteric Nerve Block (TMNB) Injection with Local AnestheticExperimental Treatment1 Intervention
Following lower third molar extraction under intravenous sedation, the patient will receive the TMNB local anesthetic nerve block using the standard dental local anesthetic, i.e,. 2% lidocaine with 1:100,000 epinephrine, on the side/s of lower wisdom molar extraction/s
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Who is running the clinical trial?
Rutgers, The State University of New JerseyLead Sponsor
455 Previous Clinical Trials
69,931 Total Patients Enrolled
2 Trials studying Acute Pain
144 Patients Enrolled for Acute Pain
Gayathri D Subramanian, PhD, DMDPrincipal InvestigatorRutgers School of Dental Medicine