SABR for Kidney Cancer

Recruiting in Palo Alto (17 mi)

Overseen byRaquibul Hannan, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 1 & 2

Waitlist Available

Sponsor: University of Texas Southwestern Medical Center

No Placebo Group

Trial Summary

What is the purpose of this trial?To evaluate the safety and feasibility of pre-operative SABR of RCC IVC tumor thrombus. To evaluate the effect of pre-operative SABR in RCC IVC tumor thrombus on relapse free survival at one year.

Eligibility Criteria

This trial is for adults with kidney cancer that has spread to the large vein (IVC) carrying blood from the lower body to the heart. Participants must be able to have an MRI or CT scan, be in fair health (ECOG 0-2), and use birth control if needed. They should agree to surgery after radiation therapy and can join even with treated metastases elsewhere.

Inclusion Criteria

Ability to understand and the willingness to sign a written informed consent

My albumin level is at least 3.4 g/dL or higher.

I agree to use birth control during the study.

+11 more

Exclusion Criteria

I have had radiation therapy close to my IVC tumor.

Contraindication for contrast-enhanced MRI as defined by the standard operating procedures of the Department of Radiology at UT Southwestern

I can have surgery and SABR even if I've had other experimental treatments.

+4 more

Participant Groups

The study tests pre-operative Stereotactic Ablative Radiation Therapy (SABR) on IVC tumor thrombus in kidney cancer patients. It aims to assess safety, feasibility, and whether this treatment before surgery can help patients remain free of cancer one year post-treatment.

1Treatment groups

Experimental Treatment

Group I: Stereotactic ablative radiation therapyExperimental Treatment1 Intervention

SABR