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Monoclonal Antibodies

AT-1501 + Islet Cell Transplant for Type 1 Diabetes

Phase 1 & 2
Recruiting
Led By John Fung, MD PhD
Research Sponsored by University of Chicago
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

"This trial is testing a drug called AT-1501, which is a man-made protein that works like the natural antibodies in our body. It is designed to help prevent the immune system from attacking trans

Who is the study for?
Adults aged 18-65 with brittle Type 1 Diabetes Mellitus, diagnosed for over 5 years and onset before age 40. Participants must have had at least three severe hypoglycemic episodes in the past year not due to missed meals or dosing errors, an HbA1c level between 7.0% and 9.5%, no C-peptide response after a meal test, impaired awareness of hypoglycemia, and be under regular diabetes management.
What is being tested?
The trial is testing AT-1501, a man-made antibody designed to suppress the immune system without harming transplanted islet cells that produce insulin. This could help prevent the body from rejecting these cells in patients with T1D who receive cell transplants to manage their condition.
What are the potential side effects?
As AT-1501 works by suppressing the immune system, potential side effects may include increased risk of infections, possible infusion reactions where the drug enters the body, allergic responses or autoimmunity issues where the body attacks its own cells.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Find a Location

Who is running the clinical trial?

Cure AllianceUNKNOWN
Juvenile Diabetes Research FoundationOTHER
235 Previous Clinical Trials
142,344 Total Patients Enrolled
4 Trials studying Diabetes
555 Patients Enrolled for Diabetes
University of ChicagoLead Sponsor
1,062 Previous Clinical Trials
840,125 Total Patients Enrolled
12 Trials studying Diabetes
7,691 Patients Enrolled for Diabetes
John Fung, MD PhDPrincipal InvestigatorUniversity of Chicago
~6 spots leftby Mar 2029
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