MORAb-202 for Resistant Ovarian Cancer

Recruiting in Palo Alto (17 mi)

+124 other locations

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: Bristol-Myers Squibb

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?This trial is testing a new drug that targets and kills cancer cells in women whose ovarian, peritoneal, or fallopian tube cancers do not respond to standard treatments. The drug combines an antibody with chemotherapy to deliver treatment directly to the cancer cells.

Eligibility Criteria

This trial is for women with high-grade serous ovarian, primary peritoneal, or fallopian tube cancer that's resistant to platinum-based treatments. They should have had 1-3 prior therapies and be in good physical condition (ECOG PS of 0 or 1). Women with certain other cancer types, severe allergies to the study drugs, significant fluid retention issues, poor lung function tests, or organ dysfunction are not eligible.

Inclusion Criteria

I can provide a tissue sample from the last 5 years or a new biopsy for testing.

I am a woman diagnosed with high-grade serous ovarian, peritoneal, or fallopian tube cancer.

I've had 1-3 treatments for my condition and am now considering a single-agent therapy.

+3 more

Exclusion Criteria

Your lung function test shows that you have trouble breathing out, breathing in, or transferring oxygen.

I need frequent drainage for fluid build-up in my body.

I have had a severe allergic reaction to certain cancer drugs or ingredients.

+5 more

Participant Groups

The trial is testing MORAb-202 against standard chemotherapy options like Paclitaxel, Pegylated Liposomal Doxorubicin (PLD), or Topotecan. It aims to see which treatment is safer and more effective for patients who haven't responded well to platinum-based chemotherapy.

2Treatment groups

Experimental Treatment

Group I: MORAb-202Experimental Treatment1 Intervention

Group II: Investigator's Choice ChemotherapyExperimental Treatment3 Interventions