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Bupivacaine for Kidney Stones

Phase 2

Waitlist Available

Led By Luke Reynolds, MD

Research Sponsored by University of Chicago

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosis of nephrolithiasis planned for flexible or semi-rigid ureteroscopy in the treatment of stone disease with ureteral stenting

Be older than 18 years old

Must not have

Neurologic disease with a diagnosis of neurogenic bladder dysfunction

Dialysis

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at 30 minutes post-emergence, 60 minutes post-emergence, 6 hours post-emergence and on post-operative day 1

Summary

This trial aims to study the effects of using bupivacaine as a pain medication after ureteroscopy for treating kidney stones. The study will compare the use of bupivacaine

Who is the study for?

This trial is for individuals undergoing ureteroscopy, a procedure to treat kidney stones. Participants should be those who are scheduled for this surgery and can provide informed consent. Specific inclusion and exclusion criteria details were not provided.

What is being tested?

The study is testing the effectiveness of bupivacaine, a local anesthetic, in reducing pain after ureteroscopy compared to normal saline (a placebo). Patients will be randomly assigned to receive either bupivacaine or saline in their bladder post-surgery.

What are the potential side effects?

Bupivacaine may cause side effects such as discomfort at the application site, dizziness, nausea, numbness around the area where it's applied. Serious side effects are rare but can include heart or nervous system problems.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am diagnosed with kidney stones and scheduled for a specific procedure with stenting.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a bladder condition due to nerve problems.

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I am on dialysis.

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I have had surgery to rebuild my bladder or ureters.

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I have had radiation therapy to my pelvic area.

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I have a transplanted or ectopic kidney.

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I have had a surgery complication like significant bleeding or damage to my urinary system.

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I might have a urinary tract infection that hasn't been treated.

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I have a history of chronic pain conditions or opioid abuse.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at 30 minutes post-emergence, 60 minutes post-emergence, 6 hours post-emergence and on post-operative day 1

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at 30 minutes post-emergence, 60 minutes post-emergence, 6 hours post-emergence and on post-operative day 1

This trial's timeline: 3 weeks for screening, Varies for treatment, and at 30 minutes post-emergence, 60 minutes post-emergence, 6 hours post-emergence and on post-operative day 1 for reporting.