Carnosine for Peripheral Arterial Disease (CIPHER Trial)

Phase 1 & 2

Waitlist Available

Led By Shahid Baba, PhD

Research Sponsored by Shahid Baba

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Subjects between 50-80 years of age

Be older than 18 years old

Must not have

Diagnosis of carnosinemia

Subjects with HIV, hepatitis, significant liver disease, active infection, anemia, organ transplant, renal disease requiring dialysis, lung disease requiring oxygen, significant congenital heart disease, cancer of any type, and untreated thyroid disease

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline,12 months

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to investigate if taking carnosine, a substance found in chicken and red meat, can improve walking ability in people with peripheral arterial disease. Previous research in heart failure patients has suggested that

Who is the study for?

This trial is for individuals with Peripheral Arterial Disease (PAD), which affects blood flow in the legs, causing pain or difficulty walking. Participants should be experiencing symptoms of PAD but not necessarily severe enough to prevent walking (non-claudication or claudication). Key eligibility details are not provided.

What is being tested?

The study tests if taking carnosine, a dietary supplement found in chicken and red meat, can improve walking ability over six months. This follows observations that heart failure patients improved their walking capacity with carnosine.

What are the potential side effects?

Specific side effects of carnosine supplementation are not detailed here; however, as a naturally occurring substance in common foods, it may be well-tolerated. Any potential side effects will likely be monitored throughout the trial.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 50 and 80 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have been diagnosed with carnosinemia.

Select...

I do not have HIV, hepatitis, significant liver disease, active infections, anemia, organ transplant, renal disease requiring dialysis, lung disease requiring oxygen, significant congenital heart disease, any type of cancer, or untreated thyroid disease.

Select...

My obesity is due to a genetic condition.

Select...

I have severe leg circulation problems leading to amputations or foot ulcers.

Select...

My diabetes is not well-controlled (HbA1c >9%).

Select...

My walking test result is between 498ft and 1600ft.