Trial Summary
What is the purpose of this trial?The purpose of this study is to determine whether carnosine (a food ingredient found in chicken and red meat) supplementation (1 g) for 6 months in subjects with peripheral arterial disease (PAD); non-claudication or claudication) improves your walking ability. Previous studies with heart failure patients had shown that carnosine supplementation increases walking capacity in these patients.
Eligibility Criteria
This trial is for individuals with Peripheral Arterial Disease (PAD), which affects blood flow in the legs, causing pain or difficulty walking. Participants should be experiencing symptoms of PAD but not necessarily severe enough to prevent walking (non-claudication or claudication). Key eligibility details are not provided.Inclusion Criteria
Willing to comply with protocol requirements
Able to provide informed consent
I speak English.
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Exclusion Criteria
I do not have HIV, hepatitis, significant liver disease, active infections, anemia, organ transplant, renal disease requiring dialysis, lung disease requiring oxygen, significant congenital heart disease, any type of cancer, or untreated thyroid disease.
I have been diagnosed with carnosinemia.
Presence of significant injury within 30 days before enrollment
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Participant Groups
The study tests if taking carnosine, a dietary supplement found in chicken and red meat, can improve walking ability over six months. This follows observations that heart failure patients improved their walking capacity with carnosine.
2Treatment groups
Experimental Treatment
Active Control
Group I: CarnosineExperimental Treatment1 Intervention
Carnosine 1 g daily for 6 months
Group II: PlaceboActive Control1 Intervention
Cellulose
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of Louisville School of Medicine, Department of Medicine, Division of Environmental MedicineLouisville, KY
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Who Is Running the Clinical Trial?
Shahid BabaLead Sponsor
National Institutes of Health (NIH)Collaborator
National Heart, Lung, and Blood Institute (NHLBI)Collaborator