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Gonadotropin-Releasing Hormone (GnRH) Agonist

Leuprolide acetate for Obesity

N/A
Waitlist Available
Led By Edward Melanson, Ph.D.
Research Sponsored by University of Colorado, Denver
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5-6 hrs
Awards & highlights

Study Summary

This trialinvestigates how hormones affect brown fat in humans, to see if they affect energy expenditure. They will use imaging and temperature tests to measure the effects.

Eligible Conditions
  • Obesity
  • Menopause

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5-6 hrs
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5-6 hrs for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Brown Adipose Tissue Activity - ColdExposure
Brown Adipose Tissue Activity -Warm Exposure
Brown Adipose Tissue Volume
Secondary outcome measures
Resting energy expenditure - after cold exposure
Resting energy expenditure - before cold exposure

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Pre-menopausal womenExperimental Treatment1 Intervention
To determine if natural declines in endogenous E2 contribute to changes in BAT activity, the investigators will compare BAT activity in pre-and post-menopausal women. We will also explore whether suppression of ovarian hormones in pre-menopausal women (using leuprolide acetate) impairs BAT activity.
Group II: Post-menopausal womenActive Control1 Intervention
To determine if natural declines in endogenous E2 contribute to changes in BAT activity, the investigators will compare BAT activity in pre-and post-menopausal women.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Leuprolide
FDA approved

Find a Location

Who is running the clinical trial?

University of OttawaOTHER
210 Previous Clinical Trials
268,120 Total Patients Enrolled
7 Trials studying Obesity
304 Patients Enrolled for Obesity
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,376 Previous Clinical Trials
4,315,695 Total Patients Enrolled
451 Trials studying Obesity
588,892 Patients Enrolled for Obesity
Université de SherbrookeOTHER
298 Previous Clinical Trials
69,869 Total Patients Enrolled
14 Trials studying Obesity
2,613 Patients Enrolled for Obesity
~9 spots leftby Jun 2025
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