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Antiplatelet agent

Clopidogrel - for CYP2C19*2 carriers for Heart Attack (ELEVATE Trial)

Phase 2
Waitlist Available
Led By Christian T Ruff, MD, MPH
Research Sponsored by The TIMI Study Group
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up approximately every 2 weeks for 8 weeks
Awards & highlights

Summary

To determine whether higher as compared with lower maintenance doses of clopidogrel can adequately improve the degree of platelet inhibition in carriers of a reduced-function CYP2C19 allele.

Eligible Conditions
  • Heart Attack
  • Percutaneous Coronary Intervention

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~approximately every 2 weeks for 8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and approximately every 2 weeks for 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Comparisons of Vasodilator-stimulated Phosphoprotein (VASP) Phosphorylation Platelet Reactivity Index (PRI)

Trial Design

2Treatment groups
Active Control
Group I: Clopidogrel - for CYP2C19*2 carriersActive Control1 Intervention
Clopidogrel for CYP2C19\*2 gene carriers
Group II: Clopidogrel - for CYP2C19*2 non-carriersActive Control1 Intervention
Clopidogrel for CYP2C19\*2 gene NON-carriers

Find a Location

Who is running the clinical trial?

The TIMI Study GroupLead Sponsor
12 Previous Clinical Trials
83,100 Total Patients Enrolled
Bristol-Myers SquibbIndustry Sponsor
2,678 Previous Clinical Trials
4,125,310 Total Patients Enrolled
SanofiIndustry Sponsor
2,187 Previous Clinical Trials
3,979,443 Total Patients Enrolled
~22 spots leftby Sep 2025
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