CBT-Based Mobile Health App for Opioid Use Disorder
(UCimFREE Trial)

Recruiting in Palo Alto (17 mi)

Overseen bySuzette Glasner, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of California, Los Angeles

No Placebo Group

Trial Summary

What is the purpose of this trial?This study is evaluating whether a mobile app can help people with opioid use disorder stay on treatment.

Eligibility Criteria

Adults over 18 with Opioid Use Disorder (OUD) who have started buprenorphine treatment within the last two weeks can join. Participants must own a mobile phone capable of texting and be able to understand English at a 6th-grade level. Those with alcohol or other substance dependencies needing detox, severe medical illnesses, or acute psychiatric symptoms like suicidality are excluded.

Inclusion Criteria

You have been diagnosed with opioid use disorder (OUD) according to the DSM-5 guidelines.

no more than 2 weeks from the date of BUP induction

You have a mobile phone that is capable of sending and receiving text messages.

+3 more

Exclusion Criteria

You have an addiction to drugs or alcohol that requires immediate medical treatment.

I do not have any severe illnesses that would make joining a study hard.

I do not have severe mental health issues requiring urgent care.

Participant Groups

The trial is testing imFREE, a cognitive-behavioral therapy-based mobile health intervention, against mHealth ED for its effectiveness in keeping patients on buprenorphine treatment and reducing opioid use among adults with OUD. It also assesses the cost-effectiveness of imFREE.

2Treatment groups

Experimental Treatment

Active Control

Group I: UC imFREE Smartphone application interventionExperimental Treatment1 Intervention

The imFREE condition is a 32-week tailored, interactive text messaging intervention targeting buprenorphine treatment retention and adherence as well as opioid use and associated health consequences. Following a face-to-face CBT session with a clinician, participants receive CBT skills training via daily text messaging, with content themes around relapse prevention, adherence behaviors, and personalized plans to overcome risk factors for treatment discontinuation.

Group II: Health Education and pamphletActive Control1 Intervention

The mHealth condition will provide participants with a manualized health psychoeducation session of equivalent duration to the face-to-face CBT session delivered to imFREE participants. Content focuses on various dimensions of health and well-being. Subsequent to this session participants will receive an informational pamphlet regarding BUP and the importance of adherence. the mHealth component of the intervention comprises text reminders for scheduled MM appointments.