PSMA PET Imaging for Prostate Cancer

Recruiting in Palo Alto (17 mi)

+9 other locations

Overseen byHeiko Schöder, MD

Age: 18+

Sex: Male

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: Memorial Sloan Kettering Cancer Center

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?The purpose of this study is to see if a new diagnostic research agent named 68Ga-HBED-CC-PSMA can show prostate cancer on a PET/CT scan that cannot be seen on other standard imaging even when the PSA levels are very low.

Eligibility Criteria

This trial is for men over 18 with biopsy-proven prostate adenocarcinoma, whose PSA levels have risen by at least 2 ng/ml after initial treatments like surgery or radiation. They must be able to undergo PET/CT scans and not have claustrophobia or other issues that would make such imaging difficult.

Inclusion Criteria

You need to be able to undergo a PET/CT or PET/MR scan without any problems.

I had surgery or radiation (or both) as my first cancer treatment.

I was first treated with surgery or specific types of therapy for my condition.

+6 more

Exclusion Criteria

Patient with claustrophobia that would preclude PET/CT or PET/MR imaging or other contraindications to CT imaging.

Participant Groups

The study tests a new diagnostic agent called 68Ga-HBED-CC-PSMA in detecting recurrent prostate cancer on PET/CT scans, especially when PSA levels are low but rising, indicating potential cancer activity.

2Treatment groups

Active Control

Group I: Ga-HBED-iPSMA PET with CT or MRIActive Control3 Interventions

Participants will have a PET scan with Ga-HBED-iPSMA. PET may be combined with CT or MRI at the discretion of the referring clinician.

Group II: Ga-HBED-iPSMA PET with MRIActive Control2 Interventions

Participants will have a PET scan with Ga-HBED-iPSMA and will be combined with MRI. If PET/MR imaging is not available, PET/CT imaging may be substituted. This arm will be closed to accrual and these patients will be analyzed separately.