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Anticoagulant

Unfractionated heparin for Septic Shock (HALO Trial)

Phase 2
Waitlist Available
Led By Ryan Zarychanski, MD MSc
Research Sponsored by University of Manitoba
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up monthly starting at individual site initiation through to end of enrollment, estimated two years
Awards & highlights

Summary

This trial is testing whether a higher dose of heparin prevents blood clots better than the standard dose in septic shock patients.

Eligible Conditions
  • Vasodilatory Shock
  • Septic Shock

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~monthly starting at individual site initiation through to end of enrollment, estimated two years
This trial's timeline: 3 weeks for screening, Varies for treatment, and monthly starting at individual site initiation through to end of enrollment, estimated two years for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Vasopressor-free days.
Secondary study objectives
Clinical Outcome # 4 - ∆SOFA score (Sequential Organ Failure Assessment)
Clinical Outcome # 5 - Hospital-free days to day 90
Clinical Outcome #1 - ICU mortality
+8 more

Side effects data

From 2021 Phase 4 trial • 30 Patients • NCT03318393
50%
Major bleeding event
100%
80%
60%
40%
20%
0%
Study treatment Arm
Unfractionated Heparin Group
Bivalirudin Group

Trial Design

2Treatment groups
Experimental Treatment
Group I: Venous thromboprophylaxis (VTE)Experimental Treatment1 Intervention
as per local standard
Group II: Unfractionated Heparin (UFH)Experimental Treatment1 Intervention
UFH initiated at 18 IU/kg/hr
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Unfractionated heparin
2019
Completed Phase 4
~8780

Find a Location

Who is running the clinical trial?

University of ManitobaLead Sponsor
612 Previous Clinical Trials
201,376 Total Patients Enrolled
5 Trials studying Septic Shock
10,497 Patients Enrolled for Septic Shock
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,373 Previous Clinical Trials
26,519,064 Total Patients Enrolled
7 Trials studying Septic Shock
2,095 Patients Enrolled for Septic Shock
CancerCare ManitobaOTHER
28 Previous Clinical Trials
5,461 Total Patients Enrolled
~24 spots leftby Sep 2025
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