Brace
Lumbar Brace for Back Pain
This trial is testing if wearing a lumbar brace for a few weeks can help people with low back pain who visit the emergency department. The brace supports the lower back, reducing movement and pain. This may decrease the need for painkillers and improve daily function. Lumbar supports are used in the treatment of low-back pain patients to prevent the onset or recurrence of low-back pain.
Biologic Implant
VIA Disc NP Allograft for Degenerative Disc Disease
This trial tests VIA Disc NP, an injection to repair damaged spinal discs, in adults aged 65+ with back pain not relieved by other treatments. The injection adds material to the damaged discs to improve function and reduce pain.
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Trials for Low Back Pain Patients
Behavioral Intervention
Non-pharmacological Pain Management for Post-Spine Surgery Pain
This trial will compare two ways of managing pain after lumbar spine surgery in the Military Health System. One group will receive the standard care, while the other will get an enriched care pathway with the hope of reducing opioids use.
Behavioral Intervention
Guideline-Based Physical Therapy for Lower Back Pain
This trial will evaluate whether following Physical Therapy Clinical Practice Guidelines can reduce pain, disability, and healthcare utilization for low back pain within the Department of Defense and Veterans Affairs healthcare systems.
Behavioral Intervention
Integrated vs. Coordinated Pain Management for Back Pain
This trial is testing whether an Integrated Care Pathway or a Coordinated Care Pathway is more effective in reducing pain and improving function for people with low back pain.
Behavioral Intervention
Stepped Care Management for Lower Back Pain
This trial will study two possible treatments for chronic low back pain, physical therapy or Move 2 Health. If neither of these treatments work after six weeks, patients will then be randomized to receive either the addition of the other treatment or the MORE Mindfulness intervention.
Trials for Lower Back Pain Patients
Behavioral Intervention
Non-pharmacological Pain Management for Post-Spine Surgery Pain
This trial will compare two ways of managing pain after lumbar spine surgery in the Military Health System. One group will receive the standard care, while the other will get an enriched care pathway with the hope of reducing opioids use.
Behavioral Intervention
Guideline-Based Physical Therapy for Lower Back Pain
This trial will evaluate whether following Physical Therapy Clinical Practice Guidelines can reduce pain, disability, and healthcare utilization for low back pain within the Department of Defense and Veterans Affairs healthcare systems.
Behavioral Intervention
Integrated vs. Coordinated Pain Management for Back Pain
This trial is testing whether an Integrated Care Pathway or a Coordinated Care Pathway is more effective in reducing pain and improving function for people with low back pain.
Behavioral Intervention
Stepped Care Management for Lower Back Pain
This trial will study two possible treatments for chronic low back pain, physical therapy or Move 2 Health. If neither of these treatments work after six weeks, patients will then be randomized to receive either the addition of the other treatment or the MORE Mindfulness intervention.
Phase 3 Trials
Procedure
Dextrose Prolotherapy for Lower Back Pain in Ehlers-Danlos Syndrome
This trial aims to show that prolotherapy using a sugar solution can effectively reduce chronic back pain in patients with hEDS. The treatment works by reducing inflammation and repairing tissues, with the help of ultrasound for precise injections.
Chemotherapy
Physical Therapy + Antidepressant for Chronic Lower Back Pain with Depression
This trial will look at how different treatments - antidepressants, physical therapy, or a combination of both - affect pain, ability to function, and depression symptoms in people with chronic low back pain.
Cell Therapy
BMAC and LAC + LP-PRP for Osteoarthritis
This trial is testing whether two minimally manipulated autologous cellular preparations can help treat knee osteoarthritis. The cellular preparations are bone marrow aspirate concentrate (BMAC) injection and combined lipoaspirate concentrate (LAC) and leukocyte poor (LP) platelet-rich plasma (PRP) injections. The trial will collect patient-reported outcome measures and blood, synovial fluid, and urine samples.
Trials With No Placebo
Behavioral Intervention
Non-pharmacological Pain Management for Post-Spine Surgery Pain
This trial will compare two ways of managing pain after lumbar spine surgery in the Military Health System. One group will receive the standard care, while the other will get an enriched care pathway with the hope of reducing opioids use.
Behavioral Intervention
Guideline-Based Physical Therapy for Lower Back Pain
This trial will evaluate whether following Physical Therapy Clinical Practice Guidelines can reduce pain, disability, and healthcare utilization for low back pain within the Department of Defense and Veterans Affairs healthcare systems.
Behavioral Intervention
Integrated vs. Coordinated Pain Management for Back Pain
This trial is testing whether an Integrated Care Pathway or a Coordinated Care Pathway is more effective in reducing pain and improving function for people with low back pain.
Behavioral Intervention
Stepped Care Management for Lower Back Pain
This trial will study two possible treatments for chronic low back pain, physical therapy or Move 2 Health. If neither of these treatments work after six weeks, patients will then be randomized to receive either the addition of the other treatment or the MORE Mindfulness intervention.
View More Related Trials
Frequently Asked Questions
Introduction to chronic low back pain
What are the top hospitals conducting chronic low back pain research?
Chronic low back pain is a condition that affects millions of people around the world, causing persistent discomfort and hindering daily activities. In the quest for effective treatments, top hospitals are leading the way with their commitment to conducting clinical trials focused on this debilitating condition. One such institution is the University of Pittsburgh in Pittsburgh, where researchers are currently undertaking three active trials specifically targeting chronic low back pain. With a total of five completed trials thus far, their dedication to finding innovative solutions began in 2011.
In Boston, Brigham and Women's Hospital joins the ranks as another trailblazer in chronic low back pain research. Currently engaged in two ongoing clinical trials addressing this issue, they have also recorded five previous studies dating back to 2011 when they first ventured into exploring potential treatments for this condition.
Heading south to Nashville brings us to Vanderbilt University Medical Center where researchers are actively involved in two chronic low back pain trials while having accomplished six previous investigations since initiating their initial trial only recently in 2019. Meanwhile, at Mayo Clinic located in Rochester, Minnesota—a hub renowned for cutting-edge medical advancements—two ongoing clinical tests aim at uncovering new approaches for managing chronic low back pain alongside six previously conducted experiments that trace its inception all the way back to 2005.
Lastly but certainly not least significant is Northwestern Memorial Hospital situated right within Chicago's bustling metropolitan landscape; known primarily for various educational institutions it harbors including prestigious Northwestern University.As part of national contributions designed towards better understanding and treating common yet distressing conditions like Chronic Low Back Pain; here we note involving themselves assertively via running couple of concurrent assessments backed by preceding two extensive investigations spanning from latest study commitments starting earlier this year i.e.,2021 itself. These esteemed hospitals represent beacons of hope amidst an affliction that afflicts many worldwide by devoting resources and expertise toward seeking novel treatment options through rigorous scientific investigation. Their collaborative efforts demonstrate unwavering support for those struggling with chronic low back pain and signify the dedication of medical professionals to enhance patients' quality of life.
Which are the best cities for chronic low back pain clinical trials?
When it comes to clinical trials for chronic low back pain, several cities have emerged as key hubs of research and development. Salt Lake City, Utah leads the way with 8 active trials focusing on interventions like Telehealth Physical Therapy, Local multimodal analgesia group, and Mindfulness-based approaches. Durham, North carolina closely follows with 7 ongoing studies investigating mHealth Coping Skills Training for Symptom Management (mCOPE), Coordinated Care Management Pathway, and Group 1: Peripheral Nerve Stimulation (PNS). Pittsburgh, Pennsylvania conducts 6 active trials exploring Pain Verbalization Repression Rules, Metformin usage in treatment plans, and various antidepressants. With 6 active trials each as well, New york City evaluates treatments such as Topical diclofenac and Low Dose Tranexamic acid while Boston focuses on interventions like Exosuit Augmented Physical Therapy. These cities provide individuals suffering from chronic low back pain access to cutting-edge clinical trials that pave the way for improved management strategies.
Which are the top treatments for chronic low back pain being explored in clinical trials?
Clinical trials exploring treatments for chronic low back pain are making significant strides, with several promising options in the spotlight. Leading the pack is VIA Disc NP, a cutting-edge therapy currently being tested in two active trials dedicated to addressing this debilitating condition. Introduced just last year in 2020, it has already made an impact with its potential to alleviate chronic low back pain. Another contender gaining attention is ED Physical Therapy, also involved in two ongoing trials specifically targeting this type of pain since its listing in 2021. Finally, ABCp emerges as a newcomer on the scene with one active trial and immense potential as a treatment option for chronic low back pain patients everywhere. As research continues to unfold, hope grows that these innovative therapies will pave the way towards improved quality of life for those suffering from chronic low back pain.
What are the most recent clinical trials for chronic low back pain?
Exciting advancements in the field of chronic low back pain research offer hope for patients seeking relief. Among these recent clinical trials is the investigation of liposomal bupivacaine, a potential treatment option currently in Phase 3 trials. Additionally, dextrose 50% intravenous solution has shown promise in alleviating chronic low back pain and is also undergoing Phase 3 testing. Another trial explores the combination of ibuprofen, dexamethasone, and educational intervention as an approach to managing this condition. Furthermore, ongoing Phase 4 studies are comparing different treatments and evaluating the effectiveness of implementing primary spine provider models for improved patient outcomes. These developments bring us closer to finding effective solutions that can transform the lives of individuals suffering from chronic low back pain.
What chronic low back pain clinical trials were recently completed?
Recent advancements in the field of chronic low back pain have been fueled by several completed clinical trials. In April 2022, Scilex Pharmaceuticals successfully wrapped up a trial evaluating the efficacy of their SP-103 treatment. Likewise, Eli Lilly and Company made significant strides with multiple trials for chronic low back pain: LY3526318 was completed in October 2021, LY3556050 reached completion in May 2021, and LY3016859 concluded its study in August 2020. These trials represent crucial contributions to our understanding of potential therapies for this persistent condition and offer hope for individuals struggling with chronic low back pain.