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Angiotensin II Receptor Blocker

Control for Post-Traumatic Stress Disorder (ANG-P Trial)

Phase 2
Waitlist Available
Led By Jeanie Park, MD
Research Sponsored by Emory University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* veterans ages 18-65 years old with PTSD and without PTSD (controls) matched for age, gender, and race.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

Summary

This trial is looking at why PTSD patients are more likely to get heart disease or high blood pressure. They will also study what causes PTSD patients to have high adrenaline levels and if a medication can improve it.

Eligible Conditions
  • Post-Traumatic Stress Disorder

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Secondary study objectives
Change in inflammatory biomarkers

Trial Design

2Treatment groups
Experimental Treatment
Group I: VeteransExperimental Treatment8 Interventions
Subjects with post-traumatic stress disorder (PTSD) will be evaluated using microneurography, static handgrip exercise, cold pressor test, combat virtual reality video clip, and baroreflex sensitivity using sodium nitroprusside and phenylephrine. For the second phase, they will be randomized to either losartan or atenolol.
Group II: ControlExperimental Treatment6 Interventions
Healthy controls will be evaluated using microneurography, static handgrip exercise, cold pressor test, combat virtual reality video clip, and baroreflex sensitivity using sodium nitroprusside and phenylephrine.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Atenolol
2007
Completed Phase 4
~3960
Microneurography
2013
Completed Phase 4
~110
Losartan
2003
Completed Phase 4
~3000
Cold Pressor Test (CPT)
2021
N/A
~20
Phenylephrine
2014
Completed Phase 4
~2040

Find a Location

Who is running the clinical trial?

Emory UniversityLead Sponsor
1,679 Previous Clinical Trials
2,583,532 Total Patients Enrolled
American Heart AssociationOTHER
343 Previous Clinical Trials
4,971,464 Total Patients Enrolled
Jeanie Park, MDPrincipal Investigator - Emory University
Emory University Hospital, Emory University Hospital Midtown, Select Specialty Hospital-Atlanta
University Of Alabama School Of Medicine (Medical School)
4 Previous Clinical Trials
440 Total Patients Enrolled
~5 spots leftby Feb 2025
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