Popular Trials
Protein Supplement
Whey Protein for Metabolic Bone Health
This trial aims to study the impact of consuming protein after exercise on bone health markers. They want to know if protein intake affects how the body responds to exercise in endurance runners. Participants will be given either
Stem Cell Therapy for Inherited Metabolic Brain Diseases
This trial is testing a new treatment for inborn errors of metabolism that includes transplanting stem cells from umbilical cords and injecting them into the spinal cord. The goal is to see if this is a safe and effective treatment for early demyelinating disease in the central nervous system.
Procedure
Stem Cell Transplantation for Osteopetrosis
This trial tests a treatment using busulfan and fludarabine to prepare patients with certain genetic disorders for a bone marrow transplant. The goal is to safely replace their bone marrow with healthy donor cells by carefully monitoring drug levels. Busulfan is used to clear out bone marrow cells before the transplant, and fludarabine is being tested as a less harmful alternative to another drug.
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Trials for Metabolic Syndrome Patients
Behavioural Intervention
Weight Loss for Obesity and Metabolic Syndrome
This trial is investigating how fat is stored in organs, and why this impacts some people's health more than others. The findings could lead to better treatments for diabetes and cardiovascular disease.
Biguanide
Metformin for Polycystic Ovary Syndrome
This trial is testing metformin, a common diabetes medication, to see if it can reduce liver fat in young people with polycystic ovary syndrome (PCOS). The study focuses on adolescents and young adults who have high liver fat and are at risk for non-alcoholic fatty liver disease (NAFLD). Metformin works by helping the body use insulin more effectively, which may lower liver fat. Metformin is an antidiabetic drug widely used to improve insulin resistance and has shown potential benefits in treating non-alcoholic fatty liver disease (NAFLD).
Procedure
Gastric Bypass vs. Diet for Type 2 Diabetes
This trial compares weight loss from surgery and dieting in obese people, some with diabetes. Both methods aim to improve how the body processes sugar and overall health by significantly reducing body weight.
Safflower Oil + Soy Pretzels for Metabolic Syndrome
This trial is testing if a new type of pretzel can help menopausal women maintain a healthy weight. The pretzel contains safflower oil and soy, which may have health benefits. The study requires five visits to the Ohio State University Clinical Research Center.
Behavioural Intervention
Exercise Programs for High-Risk Metabolic Syndrome
This trial is testing whether two different exercise interventions can reduce risk factors for breast cancer in postmenopausal African-American women with metabolic syndrome.
Trials for Obesity Patients
Behavioural Intervention
Weight Loss for Obesity and Metabolic Syndrome
This trial is investigating how fat is stored in organs, and why this impacts some people's health more than others. The findings could lead to better treatments for diabetes and cardiovascular disease.
Procedure
Gastric Bypass vs. Diet for Type 2 Diabetes
This trial compares weight loss from surgery and dieting in obese people, some with diabetes. Both methods aim to improve how the body processes sugar and overall health by significantly reducing body weight.
Safflower Oil + Soy Pretzels for Metabolic Syndrome
This trial is testing if a new type of pretzel can help menopausal women maintain a healthy weight. The pretzel contains safflower oil and soy, which may have health benefits. The study requires five visits to the Ohio State University Clinical Research Center.
Behavioural Intervention
Exercise Programs for High-Risk Metabolic Syndrome
This trial is testing whether two different exercise interventions can reduce risk factors for breast cancer in postmenopausal African-American women with metabolic syndrome.
Behavioral Intervention
Lifestyle Promotion Intervention for Obesity
This trial is testing a lifestyle intervention that uses wearable sensors to gather data on a person's physical activity. The intervention is designed to promote physical activity and reduce sedentary time to improve cardiometabolic risk factors such as obesity, hypertension, and disorders in glucose regulation.
Trials With No Placebo
Procedure
Bone Marrow Aspirate for Osteonecrosis
This trial seeks to find the best treatment for a musculoskeletal disease (ONFH) that causes pain, loss of function and may require hip replacement. It compares different joint-preserving treatments to see which works best.
Monoclonal Antibodies
Denosumab for Fibrous Dysplasia
This trial is testing denosumab, a drug that helps strengthen bones, in adults with fibrous dysplasia, a condition where bones grow abnormally. Denosumab works by stopping the cells that break down bone tissue, aiming to reduce bone pain and improve bone strength.
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Frequently Asked Questions
Introduction to osteopenia
What are the top hospitals conducting osteopenia research?
When it comes to clinical trials focused on osteopenia, a condition characterized by low bone mass and an increased risk of fractures, several hospitals are leading the way. In Saint Louis, Washington University School of Medicine is currently conducting four active trials for osteopenia. Although they don't have any past trials specifically dedicated to this condition, their commitment to ongoing research highlights their dedication in understanding and treating osteopenia. Meanwhile, the University of Alabama at Birmingham has three active trials and two previously conducted studies on record since 2012, demonstrating their investment in finding innovative approaches for managing this condition.
Notably, the prestigious Mayo Clinic located in Rochester recently initiated its first osteopenia trial in 2020 but already has two ongoing trials highlighting their eagerness to contribute new insights into this field. Similarly committed to advancing our understanding of osteopenia is the University of Missouri-Columbia with two active clinical trials; however, they haven't conducted any previous investigations on this particular topic.
It's also worth mentioning that the National Institutes of Health Clinical Center situated in Bethesda holds an impressive track record with four completed studies focused on osteopenia since recording its first trial back in 2004. Currently engaged in two active clinical trials for this condition as well, their expertise positions them as a valuable resource for individuals seeking cutting-edge advancements regarding osteopenia management.
These hospitals collectively represent medical centers at various stages along the journey towards unlocking new knowledge about osteopenia prevention and treatment options. Their endeavors underscore how each research study contributes significantly to our ever-growing understanding of this complex disease—a stepping stone toward improving lives affected by weak bones and fractures.
Which are the best cities for osteopenia clinical trials?
For individuals seeking clinical trials related to osteopenia, several cities have emerged as notable hubs for research and development. Toronto in Ontario stands out with 10 ongoing trials exploring treatments like Metformin, Healthy Volunteers, and Chemoradiotherapy with Integrated Boost Dose. Atlanta in Georgia follows closely behind with 6 active studies focusing on interventions such as Dulaglutide Injection and Magnetic Resonance Spectroscopic Imaging. Additionally, Birmingham in Alabama and New york City both offer promising opportunities for participation in osteopenia clinical trials, each hosting 5 ongoing studies that investigate various treatments ranging from PET imaging to virtual reality exergaming. Lastly, New Brunswick in New jersey completes this list of top cities for osteopenia clinical trials with its own set of diverse studies examining factors like metabolic activity of HR+/Her2- breast cancer and tailored lighting intervention. These cities provide valuable access to cutting-edge research efforts aimed at uncovering innovative approaches towards managing osteopenia and improving patient outcomes.
Which are the top treatments for osteopenia being explored in clinical trials?
In the realm of osteopenia, clinical trials are exploring various treatments to combat this condition. One treatment at the forefront is exercise, which shows promising results in two active trials dedicated to osteopenia. Since its first listing in 2001, exercise has been subject to two all-time clinical trials focused on this bone health issue. These studies shed light on the potential benefits that physical activity can bring for individuals with osteopenia, offering a non-pharmacological approach worth considering.
What are the most recent clinical trials for osteopenia?
Exciting developments in osteopenia research have brought forth several recent clinical trials that hold promise for improved treatment options. One such trial explores the potential benefits of a fasting mimicking diet, aiming to determine its efficacy in managing osteopenia. Another study focuses on an intensive lifestyle intervention combined with tirzepatide, seeking to assess their combined impact on this condition. Additionally, vericiguat is being investigated for its potential role in treating osteopenia, while virtual reality exergaming and decitabine are also being explored as novel interventions. These ongoing trials offer hope for advancing our understanding and management of osteopenia moving forward.
What osteopenia clinical trials were recently completed?
Recently completed clinical trials have shed light on innovative approaches in the realm of osteopenia treatment. In December 2019, Roswell Park Cancer Institute concluded a trial investigating the efficacy of Denosumab in addressing this condition. Another notable study, sponsored by Masonic Cancer Center at the University of Minnesota, explored the use of Calcium and vitamin d and was completed in February 2015. These trials hold promise for advancing our understanding and management of osteopenia, providing potential avenues for improved care for individuals affected by this bone disorder.