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MORE vs. CBT for Smoking Cessation

N/A
Recruiting
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 and up
Be older than 18 years old
Must not have
History of major neurological illness or head injury resulting in loss of consciousness
Among females, positive urine pregnancy test
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 weeks
Awards & highlights
No Placebo-Only Group

Summary

This trial will compare the effectiveness of MORE and CBT in reducing smoking behavior.

Who is the study for?
This trial is for adults over 18 who speak English, want to quit smoking, and have smoked for at least two years. They must be able to see well enough (with glasses if needed) to do tasks and tests. People can't join if they're pregnant, claustrophobic, use certain drugs or psychotropic meds recently, have major neurological issues or untreated illnesses, or any psychosis.
What is being tested?
The study compares the effectiveness of Mindfulness-Oriented Recovery Enhancement (MORE), which combines mindfulness with behavioral therapy to change reward processes in the brain; and Cognitive Behavioral Therapy (CBT), which helps understand how thoughts affect behavior on quitting smoking.
What are the potential side effects?
Since MORE and CBT are non-medical treatments focusing on behavior modification and thought patterns respectively, they typically don't cause physical side effects but may lead to emotional discomfort as individuals confront their smoking habits.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have had a serious brain illness or head injury that made me pass out.
Select...
I am female and my pregnancy test is positive.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Cigarette Smoking
Magnitude of change in fMRI brain connectivity
Magnitude of change in fMRI brain response to images

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: MOREExperimental Treatment1 Intervention
Group II: CBTActive Control1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Mindfulness-Oriented Recovery Enhancement (MORE)
2017
N/A
~230

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaOTHER
977 Previous Clinical Trials
7,400,717 Total Patients Enrolled
25 Trials studying Tobacco Use Disorder
2,718 Patients Enrolled for Tobacco Use Disorder
University of Missouri-ColumbiaLead Sponsor
379 Previous Clinical Trials
628,412 Total Patients Enrolled
4 Trials studying Tobacco Use Disorder
183 Patients Enrolled for Tobacco Use Disorder

Media Library

Cognitive Behavioral Therapy (CBT) Clinical Trial Eligibility Overview. Trial Name: NCT03948893 — N/A
Tobacco Use Disorder Research Study Groups: CBT, MORE
Tobacco Use Disorder Clinical Trial 2023: Cognitive Behavioral Therapy (CBT) Highlights & Side Effects. Trial Name: NCT03948893 — N/A
Cognitive Behavioral Therapy (CBT) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03948893 — N/A
Tobacco Use Disorder Patient Testimony for trial: Trial Name: NCT03948893 — N/A
~10 spots leftby Mar 2025
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