Antibiotic Irrigation for Appendicitis
(PA protocol Trial)

Recruiting in Palo Alto (17 mi)

Overseen byRobert Gates, MD

Age: < 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 2

Waitlist Available

Sponsor: Prisma Health-Upstate

No Placebo Group

Prior Safety Data

Trial Summary

What is the purpose of this trial?

This trial is testing if washing the surgical area with an antibiotic solution during appendix surgery helps prevent infections better than just using suction. It focuses on children with a burst appendix to see if this method reduces post-surgery infections.

Research Team

Robert Gates, MD

Principal Investigator

Prisma Health

Eligibility Criteria

This trial is for children and teenagers up to 18 years old who are scheduled for laparoscopic surgery due to perforated appendicitis. Participants must be willing to follow the treatment plan and come back for check-ups. Pregnant individuals or those not consenting to the study's procedures cannot join.

Inclusion Criteria

Willingness to undergo treatments, provide written informed consent, and participate in follow-up.

I am scheduled for a laparoscopic surgery to remove my appendix.

Willingness to undergo treatments, provide written informed consent, and participate in follow-up

See 3 more

Exclusion Criteria

I am not willing to sign consent or be randomly assigned a treatment.

I am over 18 years old.

Pregnancy

See 1 more

Treatment Details

Interventions

Antibiotic Rinse with Suction (Anti-bacterial Agent)
Suction Only (Procedure)

Trial OverviewThe study is testing if rinsing out the appendix area with antibiotics (gentamicin/clindamycin) during surgery helps prevent infections better than just using suction without any rinse. Kids in this study will randomly get one of these two treatments.

Participant Groups

2Treatment groups

Experimental Treatment

Active Control

Group I: Antibiotic irrigation with suctionExperimental Treatment1 Intervention

Group A: You will receive antibiotic irrigation with suction if a PA is found during surgery

Group II: suction onlyActive Control1 Intervention

Group B: You will receive suction alone if a PA is found during surgery