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Regional Anesthesia for Knee Replacement Surgery (TRUE KnORTH 2 Trial)

Phase 4

Waitlist Available

Research Sponsored by McMaster University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

* All adult patients presenting for a primary TKA.

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up postoperative day 0 (2 hours postoperatively), and morning of postoperative days 1, 2 and 3 after physiotherapy

Awards & highlights

Drug Has Already Been Approved

Pivotal Trial

Summary

"This trial will look at how well patients recover after knee replacement surgery when they receive a joint injection and a nerve block with or without continuous infusion through a catheter."

Who is the study for?

This trial is for adults who are about to have their first knee replacement surgery. It's testing different pain management techniques after the operation. People can't join if they don't meet certain health requirements or conditions that the study outlines.

What is being tested?

The study is looking at how well patients recover from knee surgery using two pain relief methods: injections with a drug called Ropivacaine, and normal saline, which is like saltwater. Some will also get an extra numbing technique in the thigh area.

What are the potential side effects?

Ropivacaine may cause side effects such as low blood pressure, nausea, vomiting, dizziness, numbness around the injection site or allergic reactions. Normal saline typically has minimal side effects but might cause irritation at the infusion site.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ postoperative day 0 (2 hours postoperatively), and morning of postoperative days 1, 2 and 3

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~postoperative day 0 (2 hours postoperatively), and morning of postoperative days 1, 2 and 3

This trial's timeline: 3 weeks for screening, Varies for treatment, and postoperative day 0 (2 hours postoperatively), and morning of postoperative days 1, 2 and 3 for reporting.