~11 spots leftby Mar 2026

Effect of Chronic Exenatide Therapy on Beta Cell Function and Insulin Sensitivity in T2DM

Recruiting in Palo Alto (17 mi)
Overseen ByEugenio Cersosimo, MD,PhD
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Phase 4
Waitlist Available
Sponsor: The University of Texas Health Science Center at San Antonio
Prior Safety Data
Breakthrough Therapy
Approved in 5 jurisdictions

Trial Summary

What is the purpose of this trial?In this study, the researchers hope to learn about SGLT2 inhibition on EGP (endogenous glucose production) and plasma glucose concentration in diabetic subjects. Researchers will examine diabetes and the role of increased plasma glucagon, decline in plasma insulin, and fall in plasma glucose concentration.

Eligibility Criteria

Participant Groups

4Treatment groups
Active Control
Placebo Group
Group I: DapagliflozinActive Control1 Intervention
4 weeks Dapagliflozin, Farxiga, 10mg 12 weeks Dapagliflozin, Farxiga, 10mg
Group II: Byetta / BydureonActive Control1 Intervention
Exenatide: 4 weeks Byetta, 5 to 10ug sc (daily) 12 weeks Bydureon 2mg sc
Group III: Byetta/Bydureon plus DapagliflozinActive Control2 Interventions
Exenatide: 4 weeks Byetta, 5 to 10ug sc (daily) 12 weeks Bydureon 2mg sc PLUS Dapagliflozin: 4 weeks Dapagliflozin, Farxiga, 10mg 12 weeks Dapagliflozin, Farxiga, 10mg
Group IV: PlaceboPlacebo Group1 Intervention
Placebo group (4 weeks and 12 weeks)
Exenatide is already approved in United States, United States, United States, European Union, European Union for the following indications:
🇺🇸 Approved in United States as Byetta for:
  • Type 2 diabetes mellitus
🇺🇸 Approved in United States as Bydureon for:
  • Type 2 diabetes mellitus
🇺🇸 Approved in United States as Bydureon BCise for:
  • Type 2 diabetes mellitus
🇪🇺 Approved in European Union as Byetta for:
  • Type 2 diabetes mellitus
🇪🇺 Approved in European Union as Bydureon for:
  • Type 2 diabetes mellitus

Find A Clinic Near You

Research locations nearbySelect from list below to view details:
University of Texas Health Science CenterSan Antonio, TX
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Who is running the clinical trial?

The University of Texas Health Science Center at San AntonioLead Sponsor
AstraZenecaIndustry Sponsor

References