Trial Summary
What is the purpose of this trial?
The investigators hope to learn the efficacy of methotrexate injections for treatment of nail psoriasis.
Eligibility Criteria
This trial is for individuals with nail psoriasis. Specific eligibility criteria are not provided, so it's important to contact the study organizers for detailed requirements on who can participate.Inclusion Criteria
I am 18 years old or older.
I have been diagnosed with nail psoriasis in at least 3 of my fingernails.
Exclusion Criteria
I haven't had radiation, chemotherapy, immunosuppressants, or certain steroids in the last 6 months.
I agree not to use any nail treatments other than what the study provides.
Subject known to have received treatment with investigational drugs or devices within 30 days prior to enrollment into this study
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Treatment Details
Interventions
- Methotrexate (Anti-metabolites)
Trial OverviewThe trial aims to test the effectiveness of methotrexate injections compared to saline (a placebo) and triamcinolone acetonide (a steroid) in treating nail psoriasis.
Participant Groups
3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Intralesional MethotrexateExperimental Treatment1 Intervention
Participants receive intralesional methotrexate injections into 1 nail bed/nail matrix every 6 weeks for 3 sessions.
Group II: Intralesional Triamcinolone AcetonideActive Control1 Intervention
Participants receive intralesional triamcinolone acetonide injections into 1 nail bed/nail matrix every 6 weeks for 3 sessions.
Group III: Intralesional Placebo (saline)Placebo Group1 Intervention
Participants receive intralesional saline injections into 1 nail bed/nail matrix every 6 weeks for 3 sessions.
Methotrexate is already approved in United States, Canada, European Union for the following indications:
🇺🇸 Approved in United States as Trexall for:
- Acute lymphoblastic leukemia
- Non-Hodgkin's lymphoma
- Osteosarcoma
- Breast cancer
- Lung cancer
- Head and neck cancer
- Psoriasis
- Rheumatoid arthritis
🇨🇦 Approved in Canada as Mexate for:
- Acute lymphoblastic leukemia
- Non-Hodgkin's lymphoma
- Osteosarcoma
- Breast cancer
- Lung cancer
- Head and neck cancer
- Psoriasis
- Rheumatoid arthritis
🇪🇺 Approved in European Union as Methotrexate for:
- Acute lymphoblastic leukemia
- Non-Hodgkin's lymphoma
- Osteosarcoma
- Breast cancer
- Lung cancer
- Head and neck cancer
- Psoriasis
- Rheumatoid arthritis
- Crohn's disease
- Ulcerative colitis
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Israel Englander Department of DermatologyNew York, NY
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Who Is Running the Clinical Trial?
Weill Medical College of Cornell UniversityLead Sponsor