← Back to Search

Sleep Restriction for High Blood Pressure (SASE2 Trial)

N/A

Waitlist Available

Led By Aric A Prather, PhD

Research Sponsored by University of California, San Francisco

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to post-rejection task, anticipated average of 42 minutes

Awards & highlights

No Placebo-Only Group

Summary

This trial will test how sleep deprivation affects a person's ability to discriminate, as well as their cardiovascular health. The study will specifically focus on African Americans to see how they are affected.

Who is the study for?

This study is for English-speaking African Americans aged 18-64 who usually sleep between 10 PM and 12 AM, with a normal sleep duration of 6.5 to 8.5 hours confirmed by actigraphy and diary. Excluded are those over age 64, BMI of 40+, with clinical sleep disorders or on medications affecting sleep/cardiovascular function.

What is being tested?

The trial examines how restricted sleep affects perceptions of discrimination and cardiovascular health in African Americans. It will also explore factors that might influence the link between racial discrimination experiences and actual sleep patterns.

What are the potential side effects?

Since this trial involves sleep restriction, potential side effects may include increased fatigue, irritability, difficulty concentrating, mood changes, and possibly elevated blood pressure due to stress.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to post-rejection task, anticipated average of 42 minutes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to post-rejection task, anticipated average of 42 minutes

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to post-rejection task, anticipated average of 42 minutes for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in blood pressure post-rejection

Secondary study objectives

Change in affect

Change in heart rate variability (HRV) in response to rejection task

Change in pre-ejection period (PEP) in response to rejection task

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Total Sleep RestrictionExperimental Treatment1 Intervention

Participants will experience a night of total sleep restriction and then undergo a social-rejection task in the morning.

Group II: Normal SleepActive Control1 Intervention

Participants will sleep in the laboratory for 8 hours and then undergo the same social-rejection paradigm as the experimental group to serve as a control comparison.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Sleep Restriction

2016

N/A

~490

Do I qualify?Apply below to find out