Sleep Restriction for High Blood Pressure
(SASE2 Trial)

Recruiting in Palo Alto (17 mi)

Overseen byAric A Prather, PhD

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of California, San Francisco

No Placebo Group

Trial Summary

What is the purpose of this trial?This study aims to to test effects of sleep loss on perceived discrimination and cardiovascular functioning as well as identify moderators of the racial discrimination and objective sleep link in a sample of 80 African Americans.

Eligibility Criteria

This study is for English-speaking African Americans aged 18-64 who usually sleep between 10 PM and 12 AM, with a normal sleep duration of 6.5 to 8.5 hours confirmed by actigraphy and diary. Excluded are those over age 64, BMI of 40+, with clinical sleep disorders or on medications affecting sleep/cardiovascular function.

Inclusion Criteria

English speaking, able to provide informed consent

Self-reported bedtime between 10 PM and 12 AM for 5/7 nights for the past 3-months (stability to be confirmed by actigraphy and sleep diary)

Self-reported sleep duration of between 6.5 and 8.5 hours for 5/7 nights for the last month (duration to be confirmed by actigraphy and sleep diary)

+2 more

Exclusion Criteria

Aged greater than 64 years (to minimize age-related differences in sleep quantity and architecture)

Body mass index of 40 or above (to exclude for obesity, which can impair physiologic recording and confound study outcomes)

Presence of any clinical sleep disorder, including insomnia and obstructive sleep apnea (OSA), as assessed by validated screening measure. OSA will also be assessed objectively during the Sleep Screening period

+2 more

Participant Groups

The trial examines how restricted sleep affects perceptions of discrimination and cardiovascular health in African Americans. It will also explore factors that might influence the link between racial discrimination experiences and actual sleep patterns.

2Treatment groups

Experimental Treatment

Active Control

Group I: Total Sleep RestrictionExperimental Treatment1 Intervention

Participants will experience a night of total sleep restriction and then undergo a social-rejection task in the morning.

Group II: Normal SleepActive Control1 Intervention

Participants will sleep in the laboratory for 8 hours and then undergo the same social-rejection paradigm as the experimental group to serve as a control comparison.