Physical Activity for Pediatric Cancer
Recruiting in Palo Alto (17 mi)
+1 other location
Age: < 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Calgary
Disqualifiers: Completed treatment >3 months, Unable physical activity, Non-English, Parent unavailable
No Placebo Group
Approved in 1 Jurisdiction
Trial Summary
What is the purpose of this trial?
Physical activity can enhance well-being among youth diagnosed with oncological or hematological diseases. We developed a tailored, 1:1, online physical activity program (i.e., IMPACT), to promote physical activity in this cohort. The proposed single-group, mixed-methods project will assess the effect of IMPACT and explore markers of implementation.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your healthcare provider.
What data supports the effectiveness of the treatment Physical Activity, Exercise, Physical Exercise, Physical Activity Intervention for pediatric cancer?
Research shows that exercise interventions for children with cancer are safe and can lead to positive health trends, such as improved physical and psychological well-being, without causing harm. Regular physical activity can help counteract the negative side effects of cancer treatment and support better overall health.12345
Is physical activity safe for children with cancer?
How is the physical activity treatment for pediatric cancer different from other treatments?
Physical activity as a treatment for pediatric cancer is unique because it focuses on improving physical and psychological well-being through exercise, rather than using medication. It aims to counteract the negative effects of cancer treatment, such as reduced motor skills and weight gain, by encouraging movement and exercise, which are safe and beneficial for children with cancer.168910
Research Team
Eligibility Criteria
The IMPACT trial is for children and adolescents aged 5-18 with cancer or blood diseases, who are currently in treatment or finished within the last 3 months. They must participate alongside a caregiver.Inclusion Criteria
I am between 5-18 years old and have a parent or caregiver involved.
I have been diagnosed with cancer or a blood disorder.
I am currently undergoing or about to start treatment for cancer or blood disorders, or I finished treatment less than 3 months ago.
Exclusion Criteria
My parent cannot be with me during my exercise sessions.
I finished my cancer treatment more than 3 months ago.
I am unable to do physical activities as determined by my healthcare team.
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Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants receive online, individualized physical activity sessions 2-3 times/week for 15-45 minutes/session
8-12 weeks
Online sessions 2-3 times per week
Follow-up
Participants are monitored for safety and effectiveness after treatment
6 months
Follow-up assessments at 6 months and 1 year
Long-term Follow-up
Participants are monitored for long-term outcomes and maintenance of physical activity
1 year
Treatment Details
Interventions
- Physical Activity (Behavioral Intervention)
Trial OverviewThis study tests an online physical activity program called IMPACT, designed to improve well-being in young patients with oncological or hematological conditions. It's a single-group study that will also look at how well the program works.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Physical activityExperimental Treatment1 Intervention
Participants will be offered online, individualized physical activity sessions 2-3 times/week for 15-45 minutes/session for 8-12 weeks.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Alberta Children's HospitalCalgary, Canada
Stollery Children's HospitalEdmonton, Canada
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Who Is Running the Clinical Trial?
University of Calgary
Lead Sponsor
Trials
827
Patients Recruited
902,000+
Stollery Children's Hospital
Collaborator
Trials
25
Patients Recruited
25,900+
Canadian Cancer Society (CCS)
Collaborator
Trials
84
Patients Recruited
42,100+
Canadian Institutes of Health Research (CIHR)
Collaborator
Trials
1417
Patients Recruited
26,550,000+
Alberta Children's Hospital
Collaborator
Trials
58
Patients Recruited
44,700+
References
Multidisciplinary Network ActiveOncoKids guidelines for providing movement and exercise in pediatric oncology: Consensus-based recommendations. [2022]Pediatric cancer leads to reduced participation in exercise and only few patients comply with national physical activity recommendations. Physically inactive behavior hinders motor development and increases physical and psychological adverse effects of therapy and incidence of sequelae. Currently, there is neither nationwide coverage nor uniform level of knowledge regarding exercise promotion. The objective of the guideline is to facilitate qualified exercise interventions through standardized procedures in addition to regular physiotherapy and overall avoid physical inactivity in pediatric cancer patients.
Exercise Intervention in Pediatric Patients with Solid Tumors: The Physical Activity in Pediatric Cancer Trial. [2022]The randomized controlled trial "Physical Activity in Pediatric Cancer" determined the effects of an inhospital exercise intervention combining aerobic and muscle strength training on pediatric cancer patients with solid tumors undergoing neoadjuvant chemotherapy.
Effects of a 6-Month, Group-Based, Therapeutic Exercise Program for Childhood Cancer Outpatients on Motor Performance, Level of Activity, and Quality of Life. [2022]Exercise interventions in pediatric oncology are feasible and safe. However, scarce data are available with regard to the effectiveness of outpatient, group-based exercise interventions. As well, the potential role of exercise to improve motor performance has not been adequately explored despite being a meaningful outcome during childhood with important implications for physical activity behavior. No study has yet demonstrated significant changes in motor performance after an exercise intervention.
Exercise interventions for patients with pediatric cancer during inpatient acute care: A systematic review of literature. [2022]Physical inactivity has been shown to exacerbate negative side effects experienced by pediatric patients undergoing cancer therapy. Exercise interventions are being created in response. This review summarizes current exercise intervention data in the inpatient pediatric oncology setting. Two independent reviewers collected literature from three databases, and analyzed data following the PRISMA statement for systematic reviews and meta-analyses. Ten studies were included, representing 204 patients. Good adherence, positive trends in health status, and no adverse events were noted. Common strategies included individual, supervised, combination training with adaptability to meet fluctuating patient abilities. We recommend that general physical activity programming be offered to pediatric oncology inpatients.
Experience of barriers and motivations for physical activities and exercise during treatment of pediatric patients with cancer. [2022]Due to growing evidence about the value of exercise in pediatric cancer patients, the purpose of this study was to determine factors that influence participation in physical activities and exercise in children and adolescents during treatment.
Synthesizing the literature on physical activity among children and adolescents affected by cancer: evidence for the international Pediatric Oncology Exercise Guidelines (iPOEG). [2021]Physical activity (PA), including exercise, is safe and beneficial for children and adolescents affected by cancer. Yet, no efforts have been made to collate the breadth of review and experimental articles exploring the effects of PA in this cohort. Thus, a scoping review of review and experimental articles reporting on the effects of PA for children and adolescents affected by cancer was undertaken. Review and experimental articles published in English, summarizing or reporting on the effects of PA interventions for children and adolescents affected by cancer were included. Articles were identified through prior literature, systematic searching, reference list scanning, stakeholder engagement, and a database update. Data were extracted, collated, assessed for quality (reviews) or risk of bias (experimental articles), and summarized narratively. A total of 1,380 articles were identified; 20 review and 69 experimental articles were included. Articles explored PA behavior, physical, psychosocial, cognitive, and "other" outcomes. Improvements, no change, or mixed results were reported across the majority of outcomes explored. Two PA-related adverse events (e.g., a treatable injury, fatigue) were described. Included articles varied greatly in quality and risk of bias. Findings confirm that PA for children and adolescents affected by cancer is a rapidly growing field. More adequately powered research, focused on priority outcomes, adopting appropriate study designs, and adhering to reporting standards is required. Addressing these gaps will enable a better understanding of the effects of PA. Nevertheless, the literature confirms moving more is beneficial and safe for children and adolescents affected by cancer.
Adverse Events During Supervised Exercise Interventions in Pediatric Oncology-A Nationwide Survey. [2021]Objectives: Exercise interventions during and after treatment for pediatric cancer are associated with beneficial physical, psychological, and social effects. However, valid data about adverse events (AEs) of such interventions have rarely been evaluated. This retrospective study evaluates AEs that occurred during supervised oncological exercise programs for pediatric cancer patients and survivors. Methods: This Germany-wide study used a self-administered online survey focusing on general program characteristics and AEs retrospectively for 2019. The questionnaire included (a) basic data on the offered exercise program, (b) AEs with consequences (Grade 2-5) that occurred in 2019 during an exercise intervention, (c) number of Grade 1 AEs, (d) safety procedures as part of the exercise programs, and (e) possibility to give feedback and describe experience with AEs in free text. Results: Out of 26 eligible exercise programs, response rate of program leaders was 92.3% (n = 24). Representatives working for Universities (n = 6), rehabilitation clinics (n = 3), acute cancer clinics (n = 12), and activity camps (n = 3) participated. In total, 35,110 exercise interventions with varying duration were recorded for 2019. Six AEs with consequences (Grade 2-3) occurred during exercise interventions after cancer treatment resulting in an incidence of 17 per 100,000 exercise interventions (0.017%). No life-threatening consequences or death were reported and no serious AE occurred during acute cancer treatment. Grade 1 AE occurred with a frequency of 983, corresponding to an incidence of 2,800 per 100,000 interventions (2.8%). Most frequent Grade 1 AE were muscle soreness, circulatory problems, and abdominal pain. The most frequent preventive safety procedures at the institutions were regular breaks, consultations with the medical treatment team, and material selection with low injury potential. Conclusions: Supervised exercise interventions for pediatric cancer patients and survivors seem to be safe and AEs with consequences comparatively rare when compared to general childhood population data. Occurrence of grade 1 AEs was common, however, causality was probably not evident between AEs and the exercise intervention. Future research should standardize assessment of AEs in clinical practice and research, and prospectively register and evaluate AEs that occur in the context of exercise interventions in pediatric cancer patients and survivors.
Physical activity programs for children diagnosed with cancer: an international environmental scan. [2021]Physical activity programs for children diagnosed with cancer may enhance health and quality of life. However, it is unknown where and in what capacity such programs are being offered internationally.
A Randomized Trial of Physical Activity in Children and Adolescents with Cancer. [2021]to evaluate the safety and efficacy of a physical activity program (PAP) in children and adolescents with cancer.
Active video games to promote physical activity in children with cancer: a randomized clinical trial with follow-up. [2022]Low levels of physical activity, musculoskeletal morbidity and weight gain are commonly reported problems in children with cancer. Intensive medical treatment and a decline in physical activity may also result in reduced motor performance. Therefore, simple and inexpensive ways to promote physical activity and exercise are becoming an increasingly important part of children's cancer treatment.