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Watermelon + Coenzyme Q10 for Kidney Transplant Care (WUBI-Q Trial)

N/A
Waitlist Available
Led By Elaine Ku
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 20 weeks

Summary

This trial will test whether watermelon and/or coenzyme Q supplementation is safe and improves kidney function in patients after a kidney transplant.

Who is the study for?
Adults over 18 who've had a kidney transplant within the last month can join this trial. They should be on standard post-transplant drugs, not underweight, and have normal potassium levels. They mustn't already eat lots of watermelon or take coenzyme Q10 supplements and should be able to visit UCSF for follow-up.
What is being tested?
The study is testing if eating more watermelon and possibly taking coenzyme Q10 supplements helps kidney function and reduces protein in urine after a transplant. Participants will either add these to their diet or stick with their usual diet or placebo.
What are the potential side effects?
Potential side effects may include changes in digestion due to increased watermelon intake or reactions to coenzyme Q10 like upset stomach, loss of appetite, nausea, vomiting, allergic rash but are generally considered safe.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 20 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 20 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Number of participants who develop adverse safety events (including low systolic blood pressure or hyperkalemia) during participation in the study
Number of patients who complete the study after randomized assignment
Secondary study objectives
Amount of interstitial fibrosis and tubular atrophy
Changes in amount of protein excretion in the urine over a 20-week period
Mean change in weight from baseline to 20 weeks
+1 more

Trial Design

4Treatment groups
Active Control
Placebo Group
Group I: Watermelon Diet & Coenzyme Q10Active Control2 Interventions
800-1200 mg of coenzyme Q10 daily plus diet high in watermelon
Group II: Usual Diet & Coenzyme Q10Active Control2 Interventions
800-1200 mg of coenzyme Q10 daily plus no watermelon in diet
Group III: Usual Diet & PlaceboPlacebo Group2 Interventions
Placebo pill plus no watermelon in diet
Group IV: Watermelon Diet & PlaceboPlacebo Group2 Interventions
Placebo pill plus diet high in watermelon

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,587 Previous Clinical Trials
14,901,106 Total Patients Enrolled
Elaine KuPrincipal InvestigatorUniversity of California, San Francisco
1 Previous Clinical Trials
63 Total Patients Enrolled

Media Library

Watermelon diet Clinical Trial Eligibility Overview. Trial Name: NCT04972552 — N/A
Kidney Transplant Research Study Groups: Usual Diet & Placebo, Watermelon Diet & Coenzyme Q10, Usual Diet & Coenzyme Q10, Watermelon Diet & Placebo
Kidney Transplant Clinical Trial 2023: Watermelon diet Highlights & Side Effects. Trial Name: NCT04972552 — N/A
Watermelon diet 2023 Treatment Timeline for Medical Study. Trial Name: NCT04972552 — N/A
~2 spots leftby Dec 2024
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