Watermelon + Coenzyme Q10 for Kidney Transplant Care

(WUBI-Q Trial)

Recruiting in Palo Alto (17 mi)

Overseen by Elaine Ku, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of California, San Francisco

Trial Summary

What is the purpose of this trial?

The objective of the proposed pilot trial is to determine the feasibility and safety of increasing watermelon consumption, with or without coenzyme Q supplementation in patients after kidney transplantation on kidney function and urinary protein excretion.

Eligibility Criteria

Adults over 18 who've had a kidney transplant within the last month can join this trial. They should be on standard post-transplant drugs, not underweight, and have normal potassium levels. They mustn't already eat lots of watermelon or take coenzyme Q10 supplements and should be able to visit UCSF for follow-up.

Inclusion Criteria

Potassium < 4.8 at time of randomization (not having high potassium already)

History of hemodialysis dependency (and not peritoneal dialysis) prior to kidney transplant

Able to provide informed consent

Exclusion Criteria

You have relied on peritoneal dialysis or have had a transplant surgery before.

< 18 years of age at the time of transplant

Potassium >=4.8 meq/L at randomization

Treatment Details

Interventions

• coenzyme Q10 (Dietary Supplement)
• Placebo (Other)
• Usual Diet (Other)
• Watermelon diet (Other)

Trial Overview The study is testing if eating more watermelon and possibly taking coenzyme Q10 supplements helps kidney function and reduces protein in urine after a transplant. Participants will either add these to their diet or stick with their usual diet or placebo.

Participant Groups

Group I: Watermelon Diet & Coenzyme Q10 Active Control 2 Interventions

800-1200 mg of coenzyme Q10 daily plus diet high in watermelon

Group II: Usual Diet & Coenzyme Q10 Active Control 2 Interventions

800-1200 mg of coenzyme Q10 daily plus no watermelon in diet

Group III: Usual Diet & Placebo Placebo Group 2 Interventions

Placebo pill plus no watermelon in diet

Group IV: Watermelon Diet & Placebo Placebo Group 2 Interventions

Placebo pill plus diet high in watermelon

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

University of California San Francisco San Francisco, CA

Who Is Running the Clinical Trial?

University of California, San Francisco Lead Sponsor

References