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Aerobic Exercise for Cognitive Impairment

N/A
Waitlist Available
Led By Curtis L Johnson, PhD
Research Sponsored by University of Delaware
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
age 60-90 years
Be older than 18 years old
Must not have
neurological or autoimmune conditions affecting cognition (e.g. Parkinson's disease, epilepsy, multiple sclerosis, head trauma with loss of consciousness greater than 30 min, large vessel infarct)
current medication use likely to affect CNS functions (e.g. long active benzodiazepines)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 12 weeks
Awards & highlights

Summary

This trial will look at whether older adults with low memory abilities can improve their brain health through aerobic exercise.

Who is the study for?
This trial is for adults aged 60-90 with mild memory issues but generally good mental function (MMSE score >24). They should not have high blood pressure, claustrophobia, metal implants, pacemakers, serious illnesses like heart disease or diabetes, recent concussions or be current smokers. Those on certain CNS-affecting meds or with major psychiatric disorders are also excluded.Check my eligibility
What is being tested?
The study tests if aerobic exercise can improve brain structure and memory in older adults by using a special MRI technique called magnetic resonance elastography. Participants will either do aerobic exercises or stretching to see which affects the brain and memory more positively.See study design
What are the potential side effects?
While there aren't direct side effects from the interventions being studied (aerobic exercise and stretching), participants may experience general risks associated with physical activity such as muscle strain or injury.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 60 and 90 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have a condition like Parkinson's, epilepsy, or MS affecting my thinking.
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I am not on medications that affect brain function.
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My blood pressure is high, over 130/80 mmHg.
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I have had a concussion in the past 2 years and more than 3 in my lifetime.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in brain mechanical properties
Secondary outcome measures
Change in cardiorespiratory fitness
Change in relational memory performance
Other outcome measures
Change in brain function
Change in brain morphometry
Change in brain white matter integrity
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Aerobic exerciseExperimental Treatment1 Intervention
Exercise training
Group II: StretchingActive Control1 Intervention
Control
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic exercise
2000
Completed Phase 2
~1130

Find a Location

Who is running the clinical trial?

National Institute on Aging (NIA)NIH
1,704 Previous Clinical Trials
28,033,221 Total Patients Enrolled
University of Illinois at Urbana-ChampaignOTHER
193 Previous Clinical Trials
37,492 Total Patients Enrolled
University of DelawareLead Sponsor
156 Previous Clinical Trials
25,536 Total Patients Enrolled

Media Library

Aerobic exercise Clinical Trial Eligibility Overview. Trial Name: NCT03855475 — N/A
Mild Cognitive Impairment Research Study Groups: Stretching, Aerobic exercise
Mild Cognitive Impairment Clinical Trial 2023: Aerobic exercise Highlights & Side Effects. Trial Name: NCT03855475 — N/A
Aerobic exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT03855475 — N/A
~6 spots leftby Jul 2025
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