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Decentering and Relapse/Recurrence in MBCT for Depression in Adults
N/A
Waitlist Available
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3-, 6-, 9-, and 12- month post-treatment follow-up
Summary
Objective: "Decentering" is defined as the ability to observe one's thoughts and feelings as temporary, objective events in the mind, and is increasingly regarded as a candidate mechanism in mindfulness-based interventions. The current study sought to examine the role of decentering, and other related variables, in the efficacy of Mindfulness-based cognitive therapy (MBCT) as compared to two active comparison conditions. Method: Formerly depressed individuals (N = 227), randomly assigned to MBCT (n = 74), relaxation group therapy (RGT; n = 77) or treatment-as-usual (TAU; n = 76), completed self-report measures of decentering and symptoms of depression at pre-, mid-, and post-treatment, and relapse was assessed at 3, 6, 9, and 12 months, post-treatment.
Eligible Conditions
- Major Depressive Disorder
- Depression
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 3-, 6-, 9-, and 12- month post-treatment follow-up
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3-, 6-, 9-, and 12- month post-treatment follow-up
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in major depressive disorder (MDD) relapse/recurrence - time to relapse/recurrence
Major depressive disorder (MDD) relapse/recurrence - incidence of
Secondary study objectives
Change in Beck Depression Inventory - Second Edition total scores
Trial Design
3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Mindfulness-based Cognitive Therapy (MBCT)Experimental Treatment1 Intervention
Remitted depressed participants received eight-weekly, two-hour MBCT sessions (Segal et al., 2013). This program combines MBSR meditation practices (e.g., body scan, mindful stretching, mindfulness of breath/body/sounds/thoughts) with traditional CT techniques (e.g., psychoeducation about depression symptoms and automatic thoughts, exercises designed to demonstrate how the nature of one's thoughts change with one's mood, questioning of automatic thoughts and creating a relapse prevention plan). Finally, participants engaged in a daily meditation practice and homework exercises directed at integrating the application of awareness skills into daily life. Each MBCT group was led by a masters-level clinician who was an active MBCT/Mindfulness-Based Stress Reduction (MBSR) instructor.
Group II: Relaxation Group Therapy (RGT)Active Control1 Intervention
The revised edition of the Changeways Relaxation Programme (Paterson, 1997) served as the active control condition to control for non-specific group factors including group participation, expectation of change or therapeutic contact and attention. The rationale was that relaxation can be used to better manage life stressors which precipitate depressive episodes. Participants received eight-weekly, two-hour relaxation training sessions. This group program combines psychoeducation regarding the effects of stress, diaphragmatic breathing, progressive muscle relaxation, passive relaxation and imagery. It also incorporates time for participants to discuss the events of the week to facilitate the supportive aspect of group participation. Finally, participants were asked to engage in daily exercises to practice the various relaxation strategies. Each RGT group was led by a doctoral-level therapist.
Group III: Treatment as usual (TAU)Placebo Group1 Intervention
Participants randomized to the TAU group were instructed that participants would receive MBCT at the end of the follow-up period and to seek help from their family doctors or other sources as the normally would, should the participants encounter symptomatic deterioration or other difficulties over the course of the study. At the end of the follow-up phase, participants in the TAU and RGT group were offered the opportunity to receive MBCT.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Mindfulness-based Cognitive Therapy (MBCT)
2008
N/A
~310
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Who is running the clinical trial?
University of British ColumbiaLead Sponsor
1,480 Previous Clinical Trials
2,494,254 Total Patients Enrolled