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The Potential of a Low Glutamate Diet as a Treatment for Pediatric Epilepsy
N/A
Waitlist Available
Led By Kathleen Holton, MPH, PhD
Research Sponsored by American University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 1 month post treatment
Awards & highlights
No Placebo-Only Group
Summary
The study is investigating if following the low glutamate diet for 1 month, as compared to care as usual, can improve seizure frequency, severity, and duration; cognitive functioning; and/or quality of life in children with epilepsy.
Eligible Conditions
- Diet Intervention
- Pediatric epilepsy
- Epilepsy
- Randomized Controlled Trials
- Childhood Epilepsy
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ at 1 month post treatment
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 1 month post treatment
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Change in seizure duration
Change in seizure frequency
Change in seizure severity
Secondary study objectives
Examine change in resting state brain waves after 1-month on the low glutamate diet
The effect of a 1-month low-glutamate diet on cognitive functioning in children with epilepsy.
The effect of a 1-month low-glutamate diet on quality of life in children with epilepsy.
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Low Glutamate dietExperimental Treatment1 Intervention
Participants are put on the low glutamate diet for one month. The low glutamate diet reduces the consumption of free glutamate, while optimizing dietary micronutrient and antioxidant intake.
Group II: Wait-listed controlActive Control1 Intervention
Participants continue care as usual. All all medications must be kept constant during the study period, unless medically necessary.
Find a Location
Who is running the clinical trial?
American UniversityLead Sponsor
20 Previous Clinical Trials
4,765 Total Patients Enrolled
Children's National Research InstituteOTHER
221 Previous Clinical Trials
258,325 Total Patients Enrolled
Kathleen Holton, MPH, PhDPrincipal Investigator - American University
American University