Maternal Diet for Preventing Food Allergies
(ESCAPE Trial)

Recruiting in Palo Alto (17 mi)

Age: 18 - 65

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Rochester

No Placebo Group

Trial Summary

What is the purpose of this trial?

Peanut allergy is the most common cause of fatal and near-fatal food-allergic reactions and egg allergy is among the two most common causes of food-induced anaphylaxis. The proposed research will explore the development of sensitization to these food(s) in infants based on maternal consumption or avoidance during pregnancy and breastfeeding.

Research Team

Eligibility Criteria

This study is for expecting mothers who are not allergic to peanuts or eggs. It's designed to see if eating or avoiding these foods during pregnancy and breastfeeding affects their baby's risk of developing food allergies.

Inclusion Criteria

Participant must be able to understand and provide informed consent

Must have history of eating peanut and egg and have tolerated consumption with no food allergy reactions

My infant's participation has parental consent.

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Exclusion Criteria

I have a long-term infection or condition like cystic fibrosis or arthritis.

My kidneys, liver, or heart are not working properly.

Mothers who refuse to eat peanut (or peanut products) and/or eggs (or products containing eggs)

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Treatment Details

Interventions

Avoidance (Behavioral Intervention)
Consumption (Behavioral Intervention)

Trial OverviewThe trial is testing the impact of maternal diet on infant allergy development. Specifically, it looks at whether mothers consuming or avoiding peanuts and eggs can influence their child's likelihood of having a peanut or egg allergy.

Participant Groups

2Treatment groups

Active Control

Group I: Arm 1 ConsumptionActive Control1 Intervention

Subjects must consume peanuts and peanut products and egg and egg products.

Group II: Arm 2 AvoidanceActive Control1 Intervention

Subjects must avoid eating peanuts and peanut products and egg and egg products.