Closed-Loop Neuromodulation for Alzheimer's Disease

Recruiting in Palo Alto (17 mi)

Overseen by Joan Camprodon, MD, PhD, MPH

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Massachusetts General Hospital

Trial Summary

What is the purpose of this trial?

The project is a placebo-controlled study that aims to use closed-loop transcranial alternating current stimulation (tACS) to study patients with symptoms of mild cognitive impairment which is likely due to Alzheimer's disease or another form of dementia (AD-MCI). Patients will undergo an EEG and complete some questionnaires and computer tasks during each study visit. The project has the following aims and hypotheses: 1.) To determine the impact of closed-loop 40 Hz tACS on the entrainment of natural gamma rhythms in patients with AD-MCI, 2.) To determine the impact of closed-loop 40 Hz tACS on cognitive performance in patients with AD-MCI, and 3.) To assess the relationship between baseline neurodegenerative burden and impact of tACS. \[exploratory\]

Eligibility Criteria

This trial is for English-speaking adults aged 50-80 with mild cognitive impairment likely due to Alzheimer's, supported by AD biomarkers. It excludes those with brain lesions, acute medical conditions like cancer or heart failure, active major organ disorders, long-term substance abuse history, and contraindications to tACS such as scalp lesions or seizure history.

Inclusion Criteria

I have mild memory problems likely due to Alzheimer's, confirmed by tests.

I am between 50 and 80 years old.

I am a native English speaker.

Exclusion Criteria

I have a diagnosed brain lesion, such as a tumor.

I do not have any worsening or uncontrolled health conditions.

I have an active blood, kidney, lung, hormone, or liver disorder.

Treatment Details

Interventions

• tACS device (Neuromodulation Therapy)

Trial Overview The study tests closed-loop transcranial alternating current stimulation (tACS) on patients with Alzheimer's-related mild cognitive impairment. It aims to see if tACS can synchronize natural brain rhythms and improve cognition. Participants will have EEGs and complete tasks during visits in this placebo-controlled study.

Participant Groups

Group I: MCI Subjects Experimental Treatment 1 Intervention

Group II: Healthy Controls Placebo Group 1 Intervention

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

Massachusetts General Hospital Charlestown, MA

Who Is Running the Clinical Trial?

Massachusetts General Hospital Lead Sponsor

References