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Adaptive Naming Treatment Schedules for Aphasia

Phase 2

Recruiting

Led By William Evans, PhD

Research Sponsored by University of Pittsburgh

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Must not have

Severe diagnosed mood or behavioral disorders that require specialize mental health interventions.

History of other acquired or progressive neurological disease.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up initial assessment (pre-treatment), multiple timepoints up to 6-months post-treatment.

Awards & highlights

No Placebo-Only Group

Summary

This trial evaluates novel treatments to help people with aphasia (language disorder) improve their ability to find words, with a focus on long-term retention and use in everyday life.

Who is the study for?

This trial is for people who have had a stroke leading to aphasia, a language disorder, and struggle with finding words. They must be at least six months post-stroke, show specific difficulties on the Comprehensive Aphasia Test, and can use telehealth services via high-speed internet. It's not for those with other neurological diseases, severe comprehension issues, uncontrolled substance dependence or serious mood disorders.

What is being tested?

The study tests three different ways of scheduling picture-based naming exercises to help improve long-term word recall and usage in daily life for individuals with aphasia. Participants will try adaptive spacing (adjusting intervals based on performance), or one of two fixed schedules with varying amounts of practice items.

What are the potential side effects?

Since this trial involves non-medical interventions like speech therapy exercises conducted through telehealth sessions, there are no direct physical side effects expected from participating in the treatments being tested.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have a severe mood or behavioral disorder that needs special mental health care.

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I have a history of a progressive neurological condition.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ initial assessment (pre-treatment), multiple timepoints up to 6-months post-treatment.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~initial assessment (pre-treatment), multiple timepoints up to 6-months post-treatment.

This trial's timeline: 3 weeks for screening, Varies for treatment, and initial assessment (pre-treatment), multiple timepoints up to 6-months post-treatment. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in correct responses in Confrontation Naming of Treated and Untreated Pictured Objects

Change in correct responses in Context Generalization of Treated and Untreated Pictured Objects

Secondary study objectives

Change in core lexicon analysis on the Aphasia Bank Discourse Protocol

Change in mean scores on the Aphasia Communication Outcome Measure Short-Form

Mean score on the Cactus and Camels Test (CCT)

+4 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

6Treatment groups

Experimental Treatment

Group I: Low-item non-adaptive spacing, then high-item non-adaptive spacing, then adaptive spacingExperimental Treatment3 Interventions