New Mapping and Treatment Method for Atrial Fibrillation
(COAST-AF Trial)

Recruiting in Palo Alto (17 mi)

Overseen byDavid H Birnie, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Ottawa Heart Institute Research Corporation

No Placebo Group

Trial Summary

What is the purpose of this trial?

This is a pilot study to assess the usefulness of ECG mapping, and enhanced MRI and PET scan imaging in identifying atrial fibrosis and arrhythmia circuits involved in persistent atrial fibrillation and in guiding an innovative AF catheter ablation strategy. It is hypothesized that identifying these critical arrhythmia circuits and atrial fibrosis with enhanced imaging and performing an individualized innovative AF catheter ablation will result in higher procedural success rates.

Research Team

Pablo B Nery, MD

Principal Investigator

Ottawa Heart Institute Research Corporation

Robert deKemp, PhD

Principal Investigator

Ottawa Heart Institute Research Corporation

Elena Pena, MD

Principal Investigator

The Ottawa Hospital

David H Birnie, MD

Principal Investigator

Ottawa Heart Institute Research Corporation

Eligibility Criteria

This trial is for adults aged 18-80 with symptomatic persistent atrial fibrillation, who have had an episode lasting more than 7 days in the past year and are due for AF catheter ablation. It's not suitable for those with reversible causes of AF, previous ablations, heart thrombus, severe valve disease, kidney issues or conditions preventing MRI scans.

Inclusion Criteria

You have ongoing symptoms of atrial fibrillation and your doctor recommends a procedure to treat it.

You have experienced an episode of AF (atrial fibrillation) lasting more than 7 days within the past year, and it has been confirmed by different types of heart monitoring tests.

You are between 18 and 80 years old.

See 1 more

Exclusion Criteria

You cannot take medication to prevent blood clots.

You have a condition called atrial fibrillation, but it can be treated and reversed.

You have had a procedure to treat atrial fibrillation in the past.

See 6 more

Treatment Details

Interventions

AF Catheter Ablation (Procedure)

Trial OverviewThe study tests if using advanced ECG mapping along with enhanced MRI and PET scans to detect arrhythmia circuits and atrial fibrosis can guide a personalized catheter ablation strategy effectively to treat persistent atrial fibrillation.