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Neuromodulation

LIFU for Autonomic Nervous System Disorders

N/A
Waitlist Available
Research Sponsored by Virginia Polytechnic Institute and State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up through study completion, an average of 1 month

Summary

This trial studies how LIFU affects the autonomic nervous system using 3 tests. Physiological recordings will be taken before and after the treatment.

Who is the study for?
This trial is for individuals with autonomic nervous system disorders who don't have claustrophobia, metal implants incompatible with MRI or CT scans, active CNS-affecting medical conditions, a history of significant head injury, substance dependence, or cardiac disease.
What is being tested?
The study tests if Low Intensity Focused Ultrasound (LIFU) targeting specific brain areas affects the body's automatic functions. Participants undergo cold pressor task, valsalva maneuver and deep breathing tasks before and after LIFU to measure changes.
What are the potential side effects?
Potential side effects are not explicitly listed but may include discomfort from the ultrasound procedure or reactions to being in an MRI/CT scan environment due to noise and confinement.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~through study completion, an average of 1 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 1 month for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Sympathetic tone response - Blood Pressure (BP)
Sympathetic tone response - Electrodermal Response (EDR)
Sympathetic tone response - Electroencephalography (EEG)
+2 more

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: dPIExperimental Treatment1 Intervention
LIFU to the dPI
Group II: ACCExperimental Treatment1 Intervention
LIFU to the ACC
Group III: ShamPlacebo Group1 Intervention
Sham LIFU application

Find a Location

Who is running the clinical trial?

Virginia Polytechnic Institute and State UniversityLead Sponsor
155 Previous Clinical Trials
25,600 Total Patients Enrolled

Media Library

Low-intensity focused ultrasound neuromodulation (Neuromodulation) Clinical Trial Eligibility Overview. Trial Name: NCT05834829 — N/A
Autonomic Nervous System Disorders Research Study Groups: ACC, dPI, Sham
Autonomic Nervous System Disorders Clinical Trial 2023: Low-intensity focused ultrasound neuromodulation Highlights & Side Effects. Trial Name: NCT05834829 — N/A
Low-intensity focused ultrasound neuromodulation (Neuromodulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05834829 — N/A
~23 spots leftby Apr 2025
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