LIFU for Autonomic Nervous System Disorders

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Virginia Polytechnic Institute and State University

No Placebo Group

Trial Summary

What is the purpose of this trial?Studying the effects of Low Intensity Focused Ultrasound (LIFU) to the dorsal posterior insula (dPI) and dorsal anterior cingulate cortex (dACC) on autonomic control using a test to probe the autonomic system. A cold pressor task will be performed pre and post LIFU application. Physiologic recordings will be recorded throughout.

Eligibility Criteria

This trial is for individuals with autonomic nervous system disorders who don't have claustrophobia, metal implants incompatible with MRI or CT scans, active CNS-affecting medical conditions, a history of significant head injury, substance dependence, or cardiac disease.

Inclusion Criteria

Does not meet exclusion criteria.

Exclusion Criteria

I have had a head injury that made me unconscious for more than 10 minutes.

I am claustrophobic, which may affect my ability to undergo scans.

Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants

+5 more

Participant Groups

The study tests if Low Intensity Focused Ultrasound (LIFU) targeting specific brain areas affects the body's automatic functions. Participants undergo cold pressor task, valsalva maneuver and deep breathing tasks before and after LIFU to measure changes.

3Treatment groups

Experimental Treatment

Placebo Group

Group I: dPIExperimental Treatment1 Intervention

LIFU to the dPI

Group II: ACCExperimental Treatment1 Intervention

LIFU to the ACC

Group III: ShamPlacebo Group1 Intervention

Sham LIFU application