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Procedure

MRF + IVIM MRI for Brain Cancer

N/A

Recruiting

Led By Samuel Chao, MD

Research Sponsored by Case Comprehensive Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Biopsy-proven cases of developed recurrent tumor or radiation necrosis

ECOG performance status 0-2.

Timeline

Screening 3 weeks

Treatment Varies

Follow Up within the total 30-45 minute scan time

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to help differentiate between brain tumors and radiation necrosis with MRI scan in just 5 minutes.

Who is the study for?

This trial is for individuals who have had radiation therapy and are diagnosed with either recurrent brain tumors or radiation necrosis. It's also open to healthy people without brain diseases. Participants should not have a history of stroke, cognitive impairments, be able to consent, and have a life expectancy over 6 months.

What is being tested?

The study tests an MRI technique called Magnetic Resonance Fingerprinting (MRF) combined with IVIM MRI without contrast. The goal is to get high-quality images quickly to distinguish between brains affected by tumor recurrence and those with tissue death due to radiation.

What are the potential side effects?

Since the intervention involves only non-invasive imaging techniques like MRF in conjunction with IVIM MRI without contrast, there are typically no direct side effects associated with this procedure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My tumor has come back or I have tissue damage from radiation.

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I can take care of myself and perform daily activities.

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I have never had a stroke or other brain blood vessel issues.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ within the total 30-45 minute scan time

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~within the total 30-45 minute scan time

This trial's timeline: 3 weeks for screening, Varies for treatment, and within the total 30-45 minute scan time for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Comparison of T1 relaxation times

Comparison of T2 relaxation times

Comparison of blood perfusion in brain tissues

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Experimental Treatment

Group I: Participants with Tumor RecurrenceExperimental Treatment1 Intervention

The MRI scans (MRF and IVIM) will be performed on participants with newly developed recurrent prior to any further therapy implementation, surgical biopsy, or resection. For the participants undergoing surgical biopsy or resection after the MRI scans, the findings from the analysis of pathological biopsied specimen will serve as pathological confirmation for the MRI imaging findings

Group II: Participants with Radiation NecrosisExperimental Treatment1 Intervention

The MRI scans (MRF and IVIM) will be performed on participants with newly developed necrosis prior to any further therapy implementation, surgical biopsy, or resection. For the participants undergoing surgical biopsy or resection after the MRI scans, the findings from the analysis of pathological biopsied specimen will serve as pathological confirmation for the MRI imaging findings

Group III: Healthy Volunteer ParticipantsExperimental Treatment1 Intervention

Healthy volunteers will be recruited to evaluate the capability of MRF in conjunction with intravoxel incoherent motion (IVIM) MRI and serve as healthy control data to compare with the participant data.

0 / 3Eligibility criteria met