Meclofenamate for Brain Cancer

Palo Alto (17 mi)

Overseen byAdrienne Boire, MD, PhD

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: Memorial Sloan Kettering Cancer Center

No Placebo Group

Trial Summary

What is the purpose of this trial?Cancer that has spread to the brain, or brain metastasis, is difficult to treat. Meclofenamate is a drug which has been shown to reduce brain metastasis growth in the laboratory. This medicine has been used in the past to treat pain. But, in this study, it will be used to prevent new brain metastasis. This is the first time that meclofenamate will be used in patients with brain metastasis. This is a pilot study which means that the purpose of this study is to determine if a larger clinical trial of meclofenamate is possible in patients with brain metastasis. This study also aims to find out what effects, good and/or bad meclofenamate has on the patient and the cancer that has spread to the brain. The investigators also want to learn more about potential effects that this drug may have in the digestive system.

Eligibility Criteria

This trial is for adults aged 18-80 with recurrent or progressive brain metastasis from solid tumors, visible on MRI. Participants must have a stable systemic disease or no evidence of disease and can't be pregnant, have had recent surgery, active bleeding issues, severe allergies to NSAIDs like meclofenamate, certain heart conditions, uncontrolled systemic cancer growth, or poor kidney/liver function.

Inclusion Criteria

I may have multiple brain metastases.

I am between 18 and 80 years old.

I can care for myself but may need occasional help.

I have at least one growing brain tumor from cancer that started elsewhere, visible on an MRI.

Exclusion Criteria

My cancer has spread to the lining of my brain and spinal cord.

My condition is getting worse over time.

I have a heart rhythm problem that needs medication or a pacemaker.

I am being treated for heart failure.

I do not have an active brain bleed.

I have not had any bleeding in my stomach or intestines in the last 6 months.

I am currently on blood thinners.

I currently have a bleeding disorder.

My kidney function is low, shown by high creatinine or low clearance.

I am allergic to certain anti-inflammatory drugs.

I cannot take medicine by mouth.

My steroid dose was raised in the last two weeks.

I am currently on medication to prevent blood clots.

My cancer originated in the brain.

I had surgery less than two weeks ago.

Treatment Details

The study tests Meclofenamate's effectiveness in preventing new brain metastases in patients whose cancer has spread to the brain. It's a pilot study aimed at seeing if larger trials are feasible and understanding the drug's impact on both the patient and their brain metastasis.

1Treatment groups

Experimental Treatment

Group I: MeclofenamateExperimental Treatment1 Intervention

All enrolled patients will receive the study drug, meclofenamate at 100 mg PO BID.