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Initial Flow Rate for Bronchiolitis

N/A

Waitlist Available

Led By Amy Cheng, MD

Research Sponsored by University of Texas Southwestern Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be younger than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24 hours from time of study

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing different oxygen flow rates in infants with severe bronchiolitis. The therapy helps these infants breathe easier by delivering a steady flow of oxygen through their nose. The goal is to find the best flow rate that improves their breathing the most. This method has been widely used in recent years for respiratory support in infants with bronchiolitis.

Eligible Conditions

Bronchiolitis
Respiratory Syncytial Virus Bronchiolitis

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24 hours from time of study

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24 hours from time of study

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours from time of study for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Treatment response to HFNC Therapy

Secondary study objectives

Length of oxygen support

Length of stay

Treatment failure to HFNC Therapy

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Experimental Treatment

Group I: Arm 3, HFNC 2 L/kg/minExperimental Treatment1 Intervention

The infant that is randomized to the HFNC therapy arm 3 will be placed on high flow at 2 L/kg/min (up to a maximum of 20 L/min) on fraction of inspired oxygen (FiO2) of 21 %. They will remain on FiO2 of 21% for a minimum of 10 minutes while monitoring SpO2. If SpO2 is \<90%, FiO2 will be slowly increased to maintain SpO2 ≥ 90 %.

Group II: Arm 2, HFNC 1.5 L/kg/minExperimental Treatment1 Intervention

The infant that is randomized to the HFNC therapy arm 2 will be placed on high flow at 1.5 L/kg/min (up to a maximum of 20 L/min) on fraction of inspired oxygen (FiO2) of 21 %. They will remain on FiO2 of 21% for a minimum of 10 minutes while monitoring SpO2. If SpO2 is \<90%, FiO2 will be slowly increased to maintain SpO2 ≥ 90 %.

Group III: Arm 1, HFNC 1 L/kg/minExperimental Treatment1 Intervention

The infant that is randomized to the HFNC therapy arm 1 will be placed on high flow at 1 L/kg/min (up to a maximum of 20 L/min) on fraction of inspired oxygen (FiO2) of 21 %. They will remain on FiO2 of 21% for a minimum of 10 minutes while monitoring SpO2. If oxygen saturation (SpO2) is \<90%, FiO2 will be slowly increased to maintain SpO2 ≥ 90 %.

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