Peritoneal Resuscitation for Liver Disease

Palo Alto (17 mi)

Overseen byHunter B Moore, M.D., P.hD.

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: Phase 1

Waitlist Available

Sponsor: University of Colorado, Denver

No Placebo Group

Trial Summary

What is the purpose of this trial?This trial is testing a method that involves putting a special fluid into the belly to reduce swelling and improve blood flow in high-risk liver transplant patients. The goal is to see if this can lower the risk of complications after surgery. This method has been shown to help critically ill trauma patients and organ donors by improving blood flow and reducing inflammation.

Eligibility Criteria

Treatment Details

1Treatment groups

Experimental Treatment

Group I: Direct Peritoneal Resuscitation (DPR) GroupExperimental Treatment1 Intervention

At the time of abdominal closure and determination that the patient will either go to extended stay or the intensive care unit, three drains will be placed per standard of care. An additional 19 French drain will be placed at the ligament of Treitz at the base of the mesentery. Following abdominal closure DPR will be initiated with commercially available 2.5% glucose-based peritoneal dialysis solution at a rate of 1.5 cc/kg/hr based on previously reported therapy in trauma. Drains will be connected to continuous wall suction. This infusion will continue for the duration the patients stay in extended stay (8 hours) if they are deemed eligible for hospital ward admission, or for 24 hours if requiring ICU care. These patients will then be observed for their hospital course and monitored for outcomes listed above.