Pre-Surgery Radiation Boost for Breast Cancer

Recruiting in Palo Alto (17 mi)

+10 other locations

Overseen byBruce G Haffty

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: Rutgers, The State University of New Jersey

No Placebo Group

Trial Summary

What is the purpose of this trial?This phase II trial investigates the safety of delivering a part (boost) of radiation treatment before breast surgery in treating patients with breast cancer that has not spread to other places in the body (non-metastatic). Radiation therapy uses high energy photons/electrons to kill tumor cells and shrink tumors. Delivering a boost radiation treatment before surgery when doctors can still visualize the tumor on imaging may help to better target the tumor and decrease the volume of normal irradiated tissue. By so doing, doctors may achieve better cosmetic outcomes and possibly better tumor control.

Eligibility Criteria

This trial is for individuals with non-metastatic breast cancer, who are in good physical condition (ECOG 0-1), and have no signs of cancer spread. Pregnant women must test negative for pregnancy. Participants should be willing to follow the study protocol and haven't had prior chest radiation or chemotherapy.

Inclusion Criteria

You can participate if you have cancer in both sides of your body at the same time.

Willingness to participate in the clinical trial and adhere to the study protocol

Individuals of all races, genders and ethnic groups are eligible for this trial

+5 more

Exclusion Criteria

You require chemotherapy before surgery.

You have received radiation therapy on the same side of your body as the breast or chest area.

You have inflammatory breast cancer at an advanced stage.

+7 more

Participant Groups

The trial studies the safety of a 'boost' dose of radiation given before surgery to target tumors more precisely, potentially improving cosmetic outcomes and tumor control. It includes quality-of-life assessments and MRI scans as part of evaluating this approach.

1Treatment groups

Experimental Treatment

Group I: Treatment (radiation therapy boost, WBI)Experimental Treatment6 Interventions

Prior to surgery, patients undergo radiation therapy boost over 4 fractions. Patients then undergo standard of care surgery 1-3 weeks from the last day of boost. 3 to 5 weeks after surgery, patients continue standard of care WBI in the absence of disease progression or unacceptable toxicity.